Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood

Kwarteng, Francis; Wang, Ruixiang; Micov, Veronika; Hausknecht, Kathryn A.; Turk, Marisa; Ishiwari, Keita; Oubraim, Saida; Wang, An‐Li; Richards, Jerry B.; Haj‐Dahmane, Samir; Shen, Roh‐Yu

doi:10.1007/s00213-022-06242-1

Cited by 4 publications

(2 citation statements)

References 84 publications

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“…Although evidence indicates the existence of sex‐specific differences in models of chronic stress, both sexes have been included only in a limited number of studies and the results in many cases are conflicting. Specifically, although findings indicate that females are more vulnerable to the negative behavioral effects and neuroendocrine alterations following chronic exposure to stressful conditions (Dalla et al., 2005; Kwarteng et al., 2022; Liu et al., 2019; Smith et al., 2018; Vieira et al., 2018; Xing et al., 2013), other studies indicate that chronic stress is more likely to induce depressive and anxiety‐like behavior in male animals (Iqbal et al., 2020; Jiang et al., 2022; Renard et al., 2005; Van Boxelaere et al., 2017). Males also exhibit increased HPA axis reactivity to short stress exposure (Lehmann et al., 1999; Reich et al., 2009; Wigger & Neumann, 1999).…”

Section: Introductionmentioning

confidence: 99%

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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This study aims at investigating whether environmental enrichment (EE) initiated in adolescence can alter chronic unpredictable stress (CUS)‐associated changes in astroglial and synaptic plasticity markers in male and female rats. To this end, we studied possible alterations in hippocampal glial fibrillary acidic protein (GFAP) and synaptophysin (SYN) in CUS rats previously housed in EE. Wistar rats on postnatal day (PND) 23 were housed for 10 weeks in standard housing (SH) or enriched conditions. On PND 66, animals were exposed to CUS for 4 weeks. SYN and GFAP expressions were evaluated in CA1 and CA3 subfields and dentate gyrus (DG). CUS reduced the expression of SYN in all hippocampal areas, whereas lower GFAP expression was evident only in CA1 and CA3. The reduced expression of SYN in DG and CA3 was evident to male SH/CUS rats, whereas the reduced GFAP expression in CA1 and CA3 was limited to SH/CUS females. EE housing increased the hippocampal expression of both markers and protected against CUS‐associated decreases. Our findings indicate that the decreases in the expression of SYN and GFAP following CUS are region and sex‐specific and underline the neuroprotective role of EE against these CUS‐associated changes.

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Section: Introductionmentioning

confidence: 99%

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Dandi,

Theotokis,

Petri

et al. 2023

Developmental Psychobiology

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“…Stress is a typical reaction to distressing or worrisome situations and becomes pathological when it persists over a long period of time (Seo et al, 2017). Chronic stress can have a significant impact on daily functioning and emotional well-being, increasing the likelihood of developing various psychiatric conditions like anxiety and depression (Hussenoeder et al, 2022, Hussenoeder et al, 2024Kwarteng et al, 2022). Increased teacher stress has been found to have a negative impact on job satisfaction and causing them to leave the teaching profession.…”

Section: Introductionmentioning

confidence: 99%

Teachers’ mental health status in new normal among public secondary schools in Jolo, Sulu

Asak,

Jalilul,

Asiri

2024

Soc. Psy. Hum. Exp.

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This study analyzed the mental health status of the public secondary teachers in Jolo, Sulu, Philippines. This study was a descriptive research that described the emotional well-being, support perception, stress level, anxiety level, depression, as well as resilience and coping mechanisms of the public teachers. Three public secondary schools were selected in this study. There were one hundred twenty (n=120) public school teachers who participated in the study—forty in each institution. This study adapted Warwick Edinburgh Mental Well-being Scale (WEMWBS), Teachers Mental Health Check-in Survey, Depression Anxiety Stress Scales (DASS-21), Connor-Davidson Resilience Scale (CD-RISC-10), and Carver Brief COPE Inventory as the research questionnaire. The teachers demonstrated positive emotional state, low levels of anxiety, stress, and depression, and high resilience, all indicative of their effective management of mental health challenges in the new normal. Specifically, they reported having the feeling of optimism, love, being supported, relaxed, and mental fortitude. They were also able to respond to the challenges they face by getting advice, seeking emotional support, self-reflection, and find comfort from their religion or spiritual beliefs. However, this study did not evidently describe the interactions between support systems and anxiety, stress, and depression levels. Hence, it is essential for further research to explore the specific types of support and coping strategies that most effectively promote these positive emotional states and resilience among teachers.

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Juvenile variable stress modulates, in female but not in male Wistar rats, ethanol intake in adulthood

Salguero,

Barey,

Virgolini

et al. 2023

Neurotoxicology and Teratology

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Adolescent chronic unpredictable stress leads to increased anxiety and attention deficit/hyperactivity-like symptoms in adulthood

Cited by 4 publications

References 84 publications

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Environmental enrichment initiated in adolescence restores the reduced expression of synaptophysin and GFAP in the hippocampus of chronically stressed rats in a sex‐specific manner

Teachers’ mental health status in new normal among public secondary schools in Jolo, Sulu

Juvenile variable stress modulates, in female but not in male Wistar rats, ethanol intake in adulthood

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