Sex-related association of serum uric acid with inflammation, kidney function and blood pressure in type 1 diabetic patients

Słomiński, Bartosz; Skrzypkowska, Maria; Ryba-Stanisławowska, Monika; Brandt, Agnieszka

doi:10.1111/pedi.12670

Cited by 7 publications

(15 citation statements)

References 43 publications

(46 reference statements)

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“…UA cannot work only as an agent of endothelial dysfunction and kidney disease, but also it influences the cardiorenal etiology and risk factors. We have found such associations, depending on sex, among T1D patients [34]. In the present study, we have observed similar differences in correlations of serum UA with inflammatory biomarkers and kidney function between wild-type carriers and KL-VS bearing patients.…”

Section: Relationship Between Serum Uric Acid Concentration and Diffesupporting

confidence: 84%

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

et al. 2020

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As the KL-VS haplotype alters secretion and activity of KLOTHO and uric acid (UA) is associated with endothelial dysfunction and inflammation, their mutual links may contribute to microalbuminuria (MA) in patients with type 1 diabetes (T1D). Therefore, we hypothesize that KL-VS polymorphism could be associated with the prevalence of MA in T1D patients, and KL-VS polymorphism could modify physiological functions and pathogenic potential of UA. We have examined 350 patients with T1D. The analysis concerned KL-VS polymorphism along with the concentrations of serum inflammatory markers, indicators of renal function, blood pressure, and lipid profile. The incidence of KL-VS genotype was lower in a group with MA in comparison to patients without this condition. Moreover, KL-VS carriers had improved indicators of renal function, lower concentrations of pro-inflammatory cytokines, and higher levels of anti-inflammatory markers. Simultaneously, among KL-VS carriers serum UA was negatively correlated with HbA1c, albumin excretion rate, ACR, CRP, TNF-α, total cholesterol, LDL-C and triglycerides, and positively correlated with HDL-C. Moreover, among wild-type KLOTHO carriers serum, UA was in positive correlation with creatinine, blood pressure, IL-12 and MCP-1, and in negative correlation with IL-10 and eGFR. Findings of our study suggest that the functional KL-VS polymorphism is independently associated with MA and the KL-VS genotype protects from the development of MA, and KL-VS polymorphism may modify physiological functions and pathogenic potential of UA by altering the levels of HbA1c, inflammatory biomarkers, indicators of renal function, blood pressure, and lipid profile. Key messages • We analyzed the KL-VS polymorphism and the UA serum level in patients with T1D. • The KL-VS polymorphism is independently associated with microalbuminuria. • The KL-VS alleles protect from the development of microalbuminuria. • KL-VS polymorphism may modify physiological functions and pathogenic potential of uric acid.

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Section: Relationship Between Serum Uric Acid Concentration and Diffesupporting

confidence: 84%

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

et al. 2020

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“…After Stratified analysis, we also found that the prognostic value of PLR remained the same for female patients or patients with eGFR less than 60 mL/min/1.73 m 2 . As we all know, females tend to mount stronger inflammatory responses than males [34][35][36][37][38], so the inflammation indicator, PLR, was more sensitive in female patients with IgAN. And for those IgAN patients with eGFR less than 60 mL/min/1.73 m 2 , they may have increased serum levels of inflammatory mediators and were more susceptible to inflammation-related vascular dysfunction and cardiovascular risk compared with healthy controls [39,40].…”

Section: Discussionmentioning

confidence: 95%

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

et al. 2020

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Purpose Platelet-to-lymphocyte ratio (PLR) was established showing the poor prognosis in several diseases, such as malignancies and cardiovascular diseases. But limited study has been conducted about the prognostic value of PLR on the long-term renal survival of patients with Immunoglobulin A nephropathy (IgAN). Methods We performed an observational cohort study enrolling patients with biopsy-proven IgAN recorded from November 2011 to March 2016. The definition of composite endpoint was eGFR decrease by 50%, eGFR < 15 mL/min/1.73 m2, initiation of dialysis, or renal transplantation. Patients were categorized by the magnitude of PLR tertiles into three groups. The Kaplan–Meier curves and multivariate Cox models were performed to determine the association of PLR with the renal survival of IgAN patients. Results 330 patients with a median age of 34.0 years were followed for a median of 47.4 months, and 27 patients (8.2%) had reached the composite endpoints. There were no differences among the three groups (PLR < 106, 106 ≤ PLR ≤ 137, and PLR > 137) in demographic characteristics, mean arterial pressure (MAP), proteinuria, and estimated glomerular filtration rate (eGFR) at baseline. The Kaplan–Meier curves showed that the PLR > 137 group was significantly more likely to poor renal outcomes than the other two groups. Using univariate and multivariate cox regression analyses, we found that PLR > 137 was an independent prognostic factor for poor renal survival in patients with IgAN. Subgroup analysis revealed that the PLR remained the prognostic value for female patients or patients with eGFR less than 60 mL/min/1.73 m2. Conclusions Our results underscored that baseline PLR was an independent prognostic factor for poor renal survival in patients with IgAN, especially for female patients or those patients with baseline eGFR less than 60 mL/min/1.73 m2.

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“…The progression of renal disease in men with T1D is associated with a decline in free estradiol levels [85], and 17 β -estradiol shows antioxidant, antiapoptotic, and anti-inflammatory properties [86]. The SUA level in boys but not girls with T1D was positively correlated with subclinical inflammation marker levels (CRP, IL-6, TNF- α ), renal function indicators (albumin excretion rate, cystatin-C level), and blood pressure; it was negatively correlated with anti-inflammatory IL-10 [87].…”

Section: Epidemiology Studiesmentioning

confidence: 99%

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Xiong

Liu

2019

International Journal of Endocrinology

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With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.

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Sex-related association of serum uric acid with inflammation, kidney function and blood pressure in type 1 diabetic patients

Abstract: Serum UA is associated with nephropathy prevalence, albeit only in boys with T1D and may be an important risk factor for predicting diabetes-related cardiorenal complications in these patients.

Cited by 7 publications

References 43 publications

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

A new potential mode of cardiorenal protection of KLOTHO gene variability in type 1 diabetic adolescents

The prognostic value of platelet-to-lymphocyte ratio on the long-term renal survival in patients with IgA nephropathy

Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

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