Effects of Uric Acid on Diabetes Mellitus and Its Chronic Complications

Abstract

With the deepening of the researches on uric acid, especially in the study of metabolic diseases, uric acid has been found to be closely related to obesity, metabolic syndrome, nonalcoholic fatty liver disease, diabetes, and other metabolic diseases. Uric acid causes a series of pathophysiological changes through inflammation, oxidative stress, vascular endothelial injury, and so on and thus subsequently promotes the occurrence and development of diseases. This review confirmed the positive correlation between uric acid and diabetes mellitus and its chronic complications through the pathogenesis and clinical studies aspects.

Serum Uric Acid Level as a Harbinger of Type 2 Diabetes: A Prospective Observation in Taiwan

“…Our data provide prospective confirmation of previous findings on the relationship between SUA levels and the risk of type 2 diabetes [12,13,[17][18][19][20][21][22][23][24][25][26]. The Rotterdam study showed that the risk of developing type 2 diabetes in the top quartile of uric acid was 1.68 times that in the lowest quartile [13].…”

“…The biological mechanisms underlying the relationship between SUA and diabetes risk remain a matter of debate. Data from animal and human experiments have indicated that UA mainly affects diabetes through inflammation, oxidative stress, and endothelial function damage [9,26,31]. It is also possible that elevated SUA may reflect prediabetes status, and SUA might be more closely associated with early-phase pathogenic mechanisms that contribute to the development of type 2 diabetes [20,23,30,32].…”

Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animals

“…Uric acid is the final product of purine metabolism, and is produced in the liver. However, the regulation of blood uric acid levels is largely carried out by the kidney (35). Many studies report that hyperuricemia causes diabetes development or a progression of diabetic complications by increasing oxidative stress (35,36).…”

“…However, the regulation of blood uric acid levels is largely carried out by the kidney (35). Many studies report that hyperuricemia causes diabetes development or a progression of diabetic complications by increasing oxidative stress (35,36). But, on the contrary, there are other studies that find that uric acid acts as an antioxidant in the early stage of the atherosclerotic process, and is the strongest determinant of plasma antioxidant capacity (37,38 Values are means ± SD.…”

Fractional Uric Acid Excretion and C-Reactive Protein Concentration in Type 2 Diabetes Mellitus: The Influence of Glycemic Control

“…In Nigeria a prevalence of 17.0% was reported [3]. Hyperuricemia has been made a part of the clusters of metabolic syndrome with abnormalities that include glucose intolerance, dyslipidemia and hypertension [5]. Elevated serum uric acid has been considered an independent risk predictor of obesity, fatty liver and diabetes mellitus.…”