Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animals

Gülbaran, Murat; Öğüt, Serdal

doi:10.20960/nh.03051

Cited by 5 publications

(2 citation statements)

References 38 publications

(30 reference statements)

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“…Olive trees originate in the eastern Mediterranean and the Kingdom of Saudi Arabia, with compounds like oleuropein, flavonoids, and phenolics (Sofowora, 1996). Animal studies on the influences of olive leaves extracts or their components have revealed several therapeutic effects such as hypoglycemic, anti-tumor and antimicrobial activity (Gürbüz and Öğüt, 2020;Morandi et al, 2021;Sánchez-Gutiérrez et al, 2021). The present study may be the first investigation aimed to evaluate the influence of olive (Olea oleaster) leaves extract on male rats exposed to Cd.…”

Section: Advances Inmentioning

confidence: 86%

The Protective Effects of Olive (Olea oleaster) Leaves Extract on Male Rats Exposed to Cadmium Toxicity

A. Al-Saeed

2023

AAVS

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E nvironmental pollution is a global issue caused by factors like population growth, economic growth, deforestation, agricultural development, urbanization, and industry. Heavy metals are essential for life's development and survival, while trace elements are found in small concentrations in biological systems (Stankovic and Stankovic, 2013). Concern over the declining quality of the environ-ment led to the implementation of a considerable number of experiments on trace elements. In plants, animals, and humans, the elementary constituents are divided into major and trace elements, with the latter category including both essential and non-essential elements; such as toxins (Asati et al., 2016). Heavy metals are dangerously prevalent in the environment and are considered useless to humans, as there is no specific and known mechanism for maintaining their homeostasis (Ding et al., 2021;Vieira et al.,

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Section: Advances Inmentioning

confidence: 86%

The Protective Effects of Olive (Olea oleaster) Leaves Extract on Male Rats Exposed to Cadmium Toxicity

A. Al-Saeed

2023

AAVS

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“…Olive Leaf Extract is regarded as one of the most effective complementary therapies for the prevention and control of type 2 diabetes. The literature contains well-established in vitro studies on the effects of oleuropein on type 2 diabetic patients [48][49][50][51][52][53][54][55][56]. However, in silico analysis of the same thing is still an open area.…”

Section: Introductionmentioning

confidence: 99%

In silico Study to Optimize the Dosage of Oleuropein with Metformin in Diabetes Management

Joshi,

Patel,

Bhatt

2023

Iraqi Journal of Science

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Type 2 diabetes mellitus (T2DM) is a potentially fatal metabolic disorder worldwide, in this COVID-19 era. Long-term allopathic treatment has a variety of side effects, prompting the search for alternative therapies. Oleuropein, the primary bioactive ingredient of Olive Leaf Extract (OLE), has shown noteworthy actions to control T2DM. The present study provides a dynamic study of % improvement in GLUT4 concentration with different doses of metformin (150mg-500mg) in combination with 500mg using a dynamic in silico model developed in Cell Designer 4.4.2, a system biology tool. The results indicated that 300mg of metformin and 500mg of oleuropein is the optimum combination to treat diabetes, ensuring a 2% improvement in GLUT4 concentration and an effective reduction in the dose of the allopathic drug metformin when taken in combination with OLE for the improvement in T2DM. The optimal dose of metformin with oleuropein was obtained successfully using our proposed in silico dynamic model. The research could be used to create an in vivo model to examine the effectiveness of herbal medicine for T2DM.

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Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract

Ben Attia,

Nahdi,

Horchani

et al. 2024

Cardiovasc Toxicol

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Antidiabetic effect of olive leaf extract on streptozotocin-induced diabetes mellitus in experimental animals

Cited by 5 publications

References 38 publications

The Protective Effects of Olive (Olea oleaster) Leaves Extract on Male Rats Exposed to Cadmium Toxicity

The Protective Effects of Olive (Olea oleaster) Leaves Extract on Male Rats Exposed to Cadmium Toxicity

In silico Study to Optimize the Dosage of Oleuropein with Metformin in Diabetes Management

Simultaneous Exposure to Noise and Toluene Induces Oxidative and Inflammatory Damage in the Heart of Wistar Rats: Therapeutic Potential of Olea europaea L. Leaf Extract

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