Sex-related alterations of aminopyrine metabolism by standardised extract of<i>Eurycoma Longifolia</i>(TAF-273)

Purwantiningsih,; Hussin, Abas Hj; Chana, K.

doi:10.1556/aalim.41.2012.3.3

Cited by 1 publication

(1 citation statement)

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“…This may enhance or reduce the metabolism of either of the drugs due to drug-drug interactions. For instance, concurrent administration of E. longifolia extract (TAF-273) and Aminopyrine in normal and diabetic rats caused marked (p<0.05) enhancement in the metabolism of Aminopyrine in a dose dependent manner via activation of G-protein, Protein Kinases G, and A in the cAMP pathways and Protein Kinase C. [59,60] Likewise, Hussin [61] showed that co-administration of TAF-273 and Rosiglitazone considerably enhanced formaldehyde formation by inducing phase I metabolism of Rosiglitazone in hepatocytes of diabetic and normal rats.…”

Section: Drug-drug Interactionsmentioning

confidence: 99%

Eurycoma longifolia Jack (Simarubaceae); Advances in Its Medicinal Potentials

Wizneh¹,

Asmawi²

2014

Phcog J.

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Eurycoma longifolia Jack is a tall slender shrub-tree which is well-reputed among the natives of South East Asia for its potent aphrodisiac effect. Its root extracts have shown important biological activities such as antitumor, antimalarial, antibacterial, anti-diabetic, anti-hypertensive, Osteoprotective, and ergogenic which are mainly attributed to quassinoids. Commercially it is available in the form of drinks (along with other herbs), capsules, or loose powders. Based on available online databases it was realized that in spite of numerous reports on medicinal properties of E. longifolia, a review of recent developments regarding phytopharmacology, safety and toxicology, pharmacokinetics, and clinical applications was lacking. Therefore, this concise yet informative piece of work was prepared by pulling together trustworthy information from all the accessible published and unpublished scientific resources to serve as a reliable source of reference for future investigations.

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Section: Drug-drug Interactionsmentioning

confidence: 99%