Sex-ratio-biasing constructs for the control of invasive lower vertebrates

Thresher, Ronald E.; Kamp, Jodie van de; Campbell, Giles; Grewe, Peter M.; Canning, Miles; Barney, Megan L.; Bax, Nicholas J.; Dunham, Rex A.; Su, Baofeng; Fulton, W

doi:10.1038/nbt.2903

Cited by 36 publications

(26 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…It is therefore straightforward to predict that this will also occur following the release of CyHV-3, although what host and viral gene changes will be involved, over what time-scale they will occur, and how mounting resistance will impact virulence evolution are currently impossible to determine. Nevertheless, the inevitability of resistance has already led to the realization that the successful control of carp in Australia will likely require not only the release of successive generations of CyHV-3, each progressively more virulent than its predecessor, but also an additional broad-scale measure to complement the effect of CyHV-3 (for example, ‘daughterless’ carp technology; [22]).…”

Section: Introductionmentioning

confidence: 99%

Cyprinid herpesvirus 3 and its evolutionary future as a biological control agent for carp in Australia

McColl

Sunarto

Holmes

2016

Virol J

View full text Add to dashboard Cite

Biological invasions are a major threat to global biodiversity. Australia has experienced many invasive species, with the common carp (Cyprinus carpio L.) a prominent example. Cyprinid herpesvirus 3 (CyHV-3) has been proposed as a biological control (biocontrol) agent for invasive carp in Australia. Safety and efficacy are critical factors in assessing the suitability of biocontrol agents, and extensive host-specificity testing suggests that CyHV-3 is safe. Efficacy depends on the relationship between virus transmissibility and virulence. Based on observations from natural outbreaks, as well as the biology of virus-host interactions, we hypothesize that (i) close contact between carp provides the most efficient transmission of virus, (ii) transmission occurs at regular aggregations of carp that favour recrudescence of latent virus, and (iii) the initially high virulence of CyHV-3 will decline following its release in Australia. We also suggest that the evolution of carp resistance to CyHV-3 will likely necessitate the future release of progressively more virulent strains of CyHV-3, and/or an additional broad-scale measure(s) to complement the effect of the virus. If the release of CyHV-3 does go ahead, longitudinal studies are required to track the evolution of a virus-host relationship from its inception, and particularly the complex interplay between transmission, virulence and host resistance.

show abstract

Section: Introductionmentioning

confidence: 99%

Cyprinid herpesvirus 3 and its evolutionary future as a biological control agent for carp in Australia

McColl

Sunarto

Holmes

2016

Virol J

View full text Add to dashboard Cite

show abstract

“…Another notable example is the extent of environmental damage caused by the introduction of the Asian carp in the USA. Recently, Thresher et al, (2014) reported a successful means of controlling invasive fish by reducing the effective population size of females64. The controllable on-off strategy for the reproductive containment of fish that we have developed provides a novel means of controlling the ecological and economic risks inherent to fish introductions.…”

Section: Discussionmentioning

confidence: 99%

A controllable on-off strategy for the reproductive containment of fish

Zhang

Chen

Cui

et al. 2015

Sci Rep

View full text Add to dashboard Cite

A major impediment to the commercialization and cultivation of transgenic fish is the potential ecological risks they pose to natural environments: a problem that could be solved by the production of sterile transgenic fish. Here, we have developed an on-off reproductive containment strategy for fish that renders the offspring sterile but leaves their parents fertile. TG1 (Tol2-CMV-GFP-pA-CMV-gal4-pA-Tol2) and TG2 (Tol2-CMV-RFP-pA-5 × UAS-as/dnd-pA-Tol2) zebrafish lines were established using a GAL4/UAS system. While the parental lines remained fertile, in the hybrid offspring, GAL4 induced 5 × UAS to drive the transcription of antisense dnd, which significantly down-regulated endogenous dnd expression. This disrupted the migration of primordial germ cells (PGCs), led to their apoptosis, and resulted in few or no PGCs migrating to the genital ridge. This process induced sterility or reduced fertility in adult fish. This on-off strategy is a potentially effective means of generating sterile fish for commercialization while retaining fertility in brood stocks, and offers a novel method to mitigate the ecological risks of fish introductions.

show abstract

“…2,16 Therefore, those working on the NCCP promote the view that, while CyHV-3 might substantially reduce carp numbers in our waterways, it must be complemented by another concurrent broadscale control measure. Daughterless carp 17 is a possible genetic strategy that is being considered under the NCCP and earlier modelling that predicted promising effects from a combination of daughterless carp and the virus encouraged optimism. 17 • Koi owners in Australia may feel concerned about their pets, but the large koi industries in Japan, Israel and the United Kingdom (in all of which CyHV-3 is now endemic) have used standard preventative measures very successfully.…”

Section: Dr Katria Lovell Queenslandmentioning

confidence: 99%

“…Daughterless carp 17 is a possible genetic strategy that is being considered under the NCCP and earlier modelling that predicted promising effects from a combination of daughterless carp and the virus encouraged optimism. 17 • Koi owners in Australia may feel concerned about their pets, but the large koi industries in Japan, Israel and the United Kingdom (in all of which CyHV-3 is now endemic) have used standard preventative measures very successfully. There is concern within the NCCP that, if vaccines were available in Australia, any vaccinated female koi escaping or being released into the wild could result in offspring with transitory protection from passive antibodies.…”

Section: Dr Katria Lovell Queenslandmentioning

confidence: 99%

News

2018

Aust Veterinary J

View full text Add to dashboard Cite

Sex-ratio-biasing constructs for the control of invasive lower vertebrates

Cited by 36 publications

References 12 publications

Cyprinid herpesvirus 3 and its evolutionary future as a biological control agent for carp in Australia

Cyprinid herpesvirus 3 and its evolutionary future as a biological control agent for carp in Australia

A controllable on-off strategy for the reproductive containment of fish

News

Contact Info

Product

Resources

About