Sex, racial differences and healthy aging in normative reference ranges on diastolic function in Ethnic Asians: 2016 ASE guideline revisited

Chang, Sheng‐Nan; Sung, Kuo‐Tzu; Huang, Wen‐Hung; Lin, Jou‐Wei; Chien, Shih‐Chieh; Hung, Ta‐Chuan; Su, Cheng‐Huang; Hung, Chung‐Lieh; Tsai, Chia‐Ti; Wu, Yen‐Wen; Chiang, Fu‐Tien; Yeh, Hung‐I; Hwang, Juey‐Jen

doi:10.1016/j.jfma.2020.12.024

Cited by 7 publications

(5 citation statements)

References 47 publications

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“…Similar findings were reported by Chahal et al [22]: while comparing data from healthy Caucasians and Indian Asians living in London, Asians had a significantly lower e 'rate and a higher E / e' than whites with similar E and E / A rates. Lower indices of the main LV diastolic function parameters served as the basis for the development of separate standards for ethnic Asians in a recently published study [23]. Nevertheless, in our study, E / A rates was higher in Shors men than non-indigenous men of Gornaya Shoria with arterial hypertension, differences in diastolic function were noted in Shors and non-indigenous women; it is quite possible that the reason for this is leveling of the initial differences following the development of the pathological changes.…”

Section: Discussionmentioning

confidence: 99%

Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

Сумин¹,

Gomozova²,

Щеглова³

et al. 2023

Preprint

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The current echocardiography reference values are derived primarily from populations in North America and Europe. It becomes necessary to study ethnically different groups of the population, which often have different living conditions, food habits and lifestyle. The aim of the study was to compare echocardiography indicators in urbanized patients with arterial hypertension of the Shor and non-indigenous ethnic groups living in the Gornaya Shoria region. The study included patients with arterial hypertension: 58 Shors (20 men and 38 women) and 50 non-indigenous residents (15 men and 35 women) of Gornaya Shoria. All underwent an echocardiographic study with an assessment of the left heart parameters. We assessed the left ventricular hypertrophy (LVH) severity, LV geometry and diastolic function in the ethnic and sex groups. Shor with hypertension no showed a significant difference in left ventricular dimensions compared to Caucasian. Severe abnormal LVH was associated in the Shors with glucose levels (OR 3.24, 95%CI 1.56-6.7, p=0,001), and in Caucasians with systolic (p=0.021) and diastolic (p=0.011) blood pressure, and heart rate (p=0.033). The Shor men were more likely to have normal LV diastolic function (p=0.029) and LV concentric remodeling (p=0.023), and less often to have normal LV geometry (p=0.015) compared to non-indigenous men. Thus, this study can be useful in assessing the impact of the development of arterial hypertension, as well as the impact of changing the lifestyle of the Shors when moving to the city from rural areas on ethnic differences in echocardiography.

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Section: Discussionmentioning

confidence: 99%

Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

Сумин¹,

Gomozova²,

Щеглова³

et al. 2023

Preprint

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“… 32 The normal references of the echocardiographic parameters were based on a previous report from the same populations. 33 …”

Section: Methodsmentioning

confidence: 99%

“…Interventricular septum thickness in diastole (IVSd), LV posterior wall thickness in diastole, and LVEF were measured according to the procedures of the American Society of Echocardiography 32 . The normal references of the echocardiographic parameters were based on a previous report from the same populations 33 …”

Section: Methodsmentioning

confidence: 99%

Cardiomyopathy correlates to nerve damage in p.A117S late‐onset transthyretin amyloid polyneuropathy

Lin

Hsueh

et al. 2022

Ann Clin Transl Neurol

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Objective Late‐onset hereditary transthyretin amyloidosis with polyneuropathy (ATTRv‐PN) is often associated with heart involvement. Recent advances in cardiac imaging allow the detection of cardiac amyloidosis. This study aimed to explore cardiomyopathy by cardiac imaging and its clinical correlates with polyneuropathy in late‐onset ATTRv‐PN. Methods Polyneuropathy was assessed by intraepidermal nerve fiber (IENF) density, nerve conduction study (NCS), autonomic function tests, quantitative sensory testing, and clinical questionnaires. Cardiomyopathy was evaluated by echocardiography, 99m Tc‐pyrophosphate (PYP) single‐photon emission computed tomography (SPECT) imaging, cardiac magnetic resonance imaging (CMR), and serum Pro‐B‐type natriuretic peptide. Healthy controls and patients with Brugada syndrome were enrolled for comparison of CMR. Results Fifty late‐onset ATTRv‐PN patients (38 men, 46 with p. A117S mutation), aged 63.7 ± 5.5 years, of polyneuropathy disability stage 1–4 were enrolled. All patients presented polyneuropathy in NCS, and 74.5% of patients had reduced IENF density in distal legs. All patients showed significant radiotracer uptake in the heart on 99m Tc‐PYP SPECT imaging, and 87.8% of patients had abnormally increased left ventricular (LV) septum thickness on echocardiography. CMR showed longer myocardial native T1, larger extracellular volume, greater LV mass index, and higher LV mass to end‐diastolic volume ratio in ATTRv‐PN patients than healthy controls and patients with Brugada syndrome. These CMR parameters were associated with skin denervation, absent sympathetic skin responses, elevated thermal thresholds, worsened NCS profiles, and functional deficits of polyneuropathy. Interpretation Late‐onset ATTRv‐PN coexisted with cardiomyopathy regardless of the clinical severity of polyneuropathy. The cardiac amyloid burden revealed by CMR was correlated with pathophysiology and clinical disability of nerve degeneration.

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“…Diastolic dysfunction has shown to be a hallmark pathological intermediate in the development of HFpEF. In fact, a cohort study in ethnic Asians demonstrated that prevalence of diastolic dysfunction as also others diastolic parameters increase with advanced age and it is greater in women overall than men ( Chang et al, 2021 ).…”

Section: Sex Differences In Cardiovascular Agingmentioning

confidence: 99%

Sex Differences in Molecular Mechanisms of Cardiovascular Aging

Justina

Miguez²,

Priviero

et al. 2021

Front. Aging

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Cardiovascular disease (CVD) is still the leading cause of illness and death in the Western world. Cardiovascular aging is a progressive modification occurring in cardiac and vascular morphology and physiology where increased endothelial dysfunction and arterial stiffness are observed, generally accompanied by increased systolic blood pressure and augmented pulse pressure. The effects of biological sex on cardiovascular pathophysiology have long been known. The incidence of hypertension is higher in men, and it increases in postmenopausal women. Premenopausal women are protected from CVD compared with age-matched men and this protective effect is lost with menopause, suggesting that sex-hormones influence blood pressure regulation. In parallel, the heart progressively remodels over the course of life and the pattern of cardiac remodeling also differs between the sexes. Lower autonomic tone, reduced baroreceptor response, and greater vascular function are observed in premenopausal women than men of similar age. However, postmenopausal women have stiffer arteries than their male counterparts. The biological mechanisms responsible for sex-related differences observed in cardiovascular aging are being unraveled over the last several decades. This review focuses on molecular mechanisms underlying the sex-differences of CVD in aging.

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Sex, racial differences and healthy aging in normative reference ranges on diastolic function in Ethnic Asians: 2016 ASE guideline revisited

Cited by 7 publications

References 47 publications

Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

Echocardiography Indices in Urbanized Shor Ethnic Group Representatives With Arterial Hypertension

Cardiomyopathy correlates to nerve damage in p.A117S late‐onset transthyretin amyloid polyneuropathy

Sex Differences in Molecular Mechanisms of Cardiovascular Aging

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