Sex of First Child as a Prognostic Factor in Breast Cancer

Juret, P; Delozier, T.; Mandard, A.M.; Couette, J.E.; Leplat, G; Vernhes, J.C.

doi:10.1016/s0140-6736(78)91204-7

Cited by 55 publications

(24 citation statements)

References 3 publications

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“…For instance, this competition might be responsible for the poor arylation of deoxyribonucleosides in our experimental conditions. Neither ribose, ribose 6.55 ppm which was attributed to the NH2 of the guanine moiety.…”

Section: Resultsmentioning

confidence: 97%

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Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

Bernadou¹,

Meunier²,

Meunier³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

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The transformation of the antitumor drug N2-methyl-9-hydroxy-ellipticinium by a peroxidase-hydrogen peroxide system, which has been shown to occur in vivo, leads to an electrophilic quinone-imine derivative. This unstable molecule arylates in vitro purine nucleosides and nucdeotides, leading to regioselective adducts substituted ouly at the 2'-O position of the ribose, as shown by mass spectrometry and NMR. It is likely that an important preliminary step in this reaction is a stacking process between the ellipticinium ion and the purine rings, which might explain this regioselectivity.Ellipticine (1, 5,11-dimethyl-6H-pyrido[4,3b]carbazole) was first described as a natural antitumor alkaloid in 1967 (1).

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Section: Resultsmentioning

confidence: 97%

“…The M+2 peaks were obtained by the fast atomic bombardment method. In desorption and chemical ionization, in both cases, the highest peak yielded mass 528 for 5 and 544 for 6 (the relative intensities of the main fragments are indicated in Fig. 2).…”

mentioning

confidence: 96%

Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

Bernadou¹,

Meunier²,

Meunier³

et al. 1984

Proc. Natl. Acad. Sci. U.S.A.

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“…Women whose first child was male had a better survival than those whose first child was female. Contradicting the findings of Juret et al, 1 two studies have reported better survival in women whose first child was female rather than male. 2,3 Another study found no association, 4 while a 4th study reconfirmed the first report.…”

mentioning

confidence: 93%

“…The sex of the child should significantly affect the prognosis of a subsequent breast cancer was first reported by Juret et al 1 in a Lancet communication in 1978. Women whose first child was male had a better survival than those whose first child was female.…”

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confidence: 95%

Sex of first child and breast cancer survival: A population-based study

Thalib

Hall

2005

Int. J. Cancer

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Previous reports on the influence of the sex of a child and prognosis of a subsequent breast cancer have been conflicting. We took advantage of a number of large and good quality, nationwide Registries in Sweden to evaluate the prognostic value of the sex of the first child in breast cancer. A population-based cohort of 32,003 women born after 1935 and diagnosed with primary breast cancer between 1958 and 1997 was generated by linking a number of Swedish registries including Swedish Cancer Registry, Cause of Death Registry, Swedish Generation Registry and the Registry of Population and Population changes. Of these, 4,251 were nulliparous, 2,732 had only a boy and 2,497 had only a girl prior to diagnosis. We used this subpopulation to quantify the association between the sex of the first child and breast cancer-specific mortality, using the Cox proportional hazards. Sex of the child did not significantly influence the prognosis of breast cancer. Stratifying by age and adjusting for age at diagnosis, calendar period, time since last birth and age at first child did not alter the results. Our study, the largest up to date, failed to identify evidence to support the proposed association between the sex of the first child and breast cancer survival. Given the previous reports that advocated taking sex of the first child into consideration in making decisions related to breast cancer therapy, our findings are reassuring and clinically important. ' 2005 Wiley-Liss, Inc.Key words: gender of first child; breast cancer survival; prognosis; epidemiologyThe sex of the child should significantly affect the prognosis of a subsequent breast cancer was first reported by Juret et al.1 in a Lancet communication in 1978. Women whose first child was male had a better survival than those whose first child was female. Contradicting the findings of Juret et al.,1 two studies have reported better survival in women whose first child was female rather than male.2,3 Another study found no association, 4 while a 4th study reconfirmed the first report.5 Thus, the issue of whether the sex of the child influence the prognosis of breast cancer remains unsettled. Apart from varying strategies for selection of study population, insufficient sample sizes and inaccurate ascertainment of the birth history might explain these contradictory findings.We linked nationwide registries including Swedish Cancer Registry and Multi-Generation Registry, which gave us access to all incident breast cancers with complete follow up and objective ascertainment of sex, number and dates of all births, to evaluate the prognostic value of the sex of the first child in women with breast cancer, stratified by age at diagnosis. MethodsSince January, 1, 1947, the Civil Registration System in Sweden has assigned an individually unique registration number to all residents and citizens. This number is used in all national registries and permits accurate linkage of information obtained from different registries in Sweden. Our analyses are based on a database that was created...

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“…Elipticinas (Figura 1) constituem uma ampla classe de compostos com atividade antitumoral 1 . Além da alta citotoxicidade em célu-las cancerosas, estas moléculas são especialmente interessantes do ponto de vista clínico devido aos efeitos colaterais reduzidos 2 .…”

Section: Introductionunclassified

Estrutura e propriedades de elipticinas

Cirino¹,

Belletato²,

Dantas³

et al. 2005

Quím. Nova

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Recebido em 9/12/03; aceito em 1/9/04; publicado na web em 12/11/04 STRUCTURE AND PROPERTIES OF ELLIPTICINES. The ellipticines constitute a broad class of molecules with antitumor activity. In the present work we analyzed the structure and properties of a series of ellipticine derivatives in the gas phase and in solution using quantum mechanical and Monte Carlo methods. The results showed a good correlation between the solvation energies in water obtained with the continuum model and the Monte Carlo simulation. Molecular descriptors were considered in the development of QSAR models using the DNA association constant (log K app ) as biological data. The results showed that the DNA binding is dominated by electronic parameters, with small contributions from the molecular volume and area.Keywords: ellipticine; ab initio calculation; QSAR. INTRODUÇÃOElipticinas (Figura 1) constituem uma ampla classe de compostos com atividade antitumoral 1 . Além da alta citotoxicidade em célu-las cancerosas, estas moléculas são especialmente interessantes do ponto de vista clínico devido aos efeitos colaterais reduzidos 2 . O modo de ação das elipticinas tem sido amplamente estudado, entretanto, conclusões definitivas sobre os aspectos moleculares relevantes para a ação biológica não foram ainda relatadas 3 . O núcleo molecular básico das elipticinas é constituído de um grupamento carbazol ligado a um anel piridina, propiciando a deslocalização eletrônica sobre toda a molécula. Esta estrutura relativamente simples tem permitido a síntese de mais de 70 análogos distintos 3 , com as principais modificações sendo a inclusão de um grupo hidroxila nas posições C 9 e C 7 , e alquilação das posições N 2 , N 6 e C 1 (ver Figura 1). Mais recentemente 4 , novas elipticinas substituídas em C 9 foram sintetizadas visando obter derivados com citotoxicidade seletiva.No presente trabalho, a estrutura e as propriedades moleculares de algumas elipticinas foram determinadas através de cálculos ab initio em fase gasosa. As energias de solvatação foram calculadas utilizando modelos contínuos de solvatação e simulação de Monte Carlo. A estrutura do solvente ao redor de alguns sítios das molécu-las foi analisada visando identificar características do processo de solvatação, específicas para os diferentes análogos. Na parte final do trabalho, modelos quantitativos de relação estrutura-atividade (QSAR) foram construídos e analisados. METODOLOGIA DE CÁLCULOO conjunto de moléculas estudadas no presente trabalho é apresentado na Tabela 1. Estes análogos foram selecionados de acordo com a disponibilidade de parâmetros biológicos quantitativos 3 e características estruturais dissimilares dentro desta classe de moléculas. Para cada composto descrito na Tabela 1, a geometria foi completamente otimizada no nível HF/6-31G(d) e caracterizada como mínimo verdadeiro na Superfície de Energia Potencial (PES) através do cálcu-lo de freqüências harmônicas. Cargas atômicas ChelpG (Q), momento de dipolo elétrico (µ) e energias dos orbitais moleculares de fronteira (HOMO e ...

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Sex of First Child as a Prognostic Factor in Breast Cancer

Cited by 55 publications

References 3 publications

Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

Regioselective arylation of ribose in adenosine and guanosine with the antitumor drug N2-methyl-9-hydroxyellipticinium acetate.

Sex of first child and breast cancer survival: A population-based study

Estrutura e propriedades de elipticinas

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