Sex molecular diagnosis on critical samples: Comparison of different methodologies

Palomo-Díez, Sara; Gomes, Cláudia; Martínez-Labarga, Cristina; Lelli, Roberta; Rickards, Olga; Velasco‐Vázquez, Javier; Arroyo, Ángel Esparza; Arroyo-Pardo, Eduardo

doi:10.1016/j.fsigss.2017.09.168

Cited by 1 publication

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“…However, genetic variations and forensic features of insertion/deletion polymorphisms (InDels) in this region remain unclear. InDels, combined with all the desirable features of both STR and SNP, have been used in archaeological and anthropological research (Bouwman et al, 2012;Palomo-Díez et al, 2017), ancestry inference (Romanini et al, 2015) and population genetic structure reconstruction (Pereira et al, 2009) after Weber et al first reported it in 2002 (Weber et al, 2002). Owing to the advantages of abundant distribution in the human genome, small amplicon size and low mutation rate (Fondevila et al, 2012;Weber et al, 2002), as well as absence of stutter peaks which enable mixed forensic stain analysis easily, InDels were considered as desirable genetic markers in forensic science, especially in highly degraded DNA analyses, mixed stain analyses, and complex kinship analyses.…”

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confidence: 99%

RETRACTED: Genetic diversity and phylogenetic structure of four Tibeto‐Burman‐speaking populations in Tibetan‐Yi corridor revealed by insertion/deletion polymorphisms

Zou

Wang

et al. 2020

Molec Gen & Gen Med

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Background: Insertion/deletion polymorphisms (InDels), combined with all the desirable features of both short tandem repeat and single nucleotide polymorphism, have been used in archaeological and anthropological research, population genetics and forensic application. Methods: Thirty InDels in 530 individuals residing in the Tibetan-Yi corridor (142 Dujiangyan Tibetans, 164 Muli Tibetans, 187 Xichang Yis, and 37 Yanyuan Mosuos) were genotyped using the Investigator DIPplex. Forensic parameters and allele frequency spectrum were calculated. Genetic relationships between the investigated populations and worldwide and nationwide populations were assessed based on both the allele frequency distribution and genotype data. Results: The combined powers of exclusion were 0.9807 (Dujiangyan Tibetan), 0.9880 (Muli Tibetan), 0.9852 (Xichang Yi) and 0.9892 (Yanyuan Mosuo). The combined powers of discrimination were 0.999999999983 (Dujiangyan Tibetan), 0.999999999942 (Muli Tibetan), 0.999999999982 (Xichang Yi) and 0.999999999962 (Yanyuan Mosuo), respectively. The comprehensive population comparisons among worldwide and nationwide populations uniformly illustrated that the investigated populations have a genetically closer relationship with Tibeto-Burman-speaking populations and geographically adjacent populations. Conclusion: These 30 loci can be regarded as an efficient genetic tool in forensic individual identification and as a supplementary tool in paternity testing in Dujiangyan Tibetan, Muli Tibetan, Xichang Yi, and Yanyuan Mosuo. The genetic proximity between the four populations in the Tibetan-Yi corridor and other populations is strongly correlated with the linguistic origin and geographical distance. K E Y W O R D S

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