Sex moderated and RSA mediated effects of prenatal cocaine exposure on behavior problems at age 7

Finger, Brent; McNeill, Vanessa; Schuetze, Pamela; Eiden, Rina D.

doi:10.1016/j.ntt.2021.107052

Cited by 3 publications

(1 citation statement)

References 28 publications

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“…However, the effects of PDU on offspring's problem behaviors are not consistently evident. Some studies, for instance, have found nonsignificant associations between PDU and problem behaviors in school-aged children (Diaz et al, 2014;Finger et al, 2022;Nair et al, 2008;O'Connell & Fried, 1991;Ornoy et al, 1996;Richardson et al, 1996), especially after adjusting for perinatal and rearing environmental influences (e.g., Nair et al, 2008). Similarly, several other studies found reduced or minimal associations between PDU and school-aged children's problem behaviors, after adjusting for childrearing environmental influences (D. S. Bennett et al, 2002;O'Connell & Fried, 1991).…”

Section: The Effects Of Pdu On Problem Behaviors In School-age Childrenmentioning

confidence: 99%

The effects of illicit drug use during pregnancy and parental hostility on problem behaviors in school-aged children over and above genetic influences.

Liu,

Leve,

Shaw

et al. 2024

Developmental Psychology

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Previous work has examined the impact of prenatal illicit drug use (PDU) on children’s problem behaviors. However, many PDU-related risk factors, including genetic and rearing environmental risks, can also influence offspring’s problem behaviors, thus confounding PDU, genetic, and rearing environmental influences. This study aimed to (a) identify effects of PDU on school-aged children’s problem behaviors, including both externalizing and internalizing behaviors at Age 7, after controlling genetic and specific rearing environmental (e.g., maternal and paternal hostility at Ages 4.5 and 6) influences and (b) examine interaction effects between PDU and maternal and paternal hostility in predicting children’s problem behaviors at Age 7. We used a parent–offspring adoption design to partition genetic and prenatal effects from postnatal rearing environmental influences. Participants were 561 children adopted at birth (42% female; 56% White, 19% multiracial, 13% Black/African American, 11% Latine, and 1% other), their adoptive parents, and their birth parents. Results indicate that PDU did not show a direct impact on Age 7 problem behaviors before or after controlling genetic risks and adoptive mother’s and father’s hostility. However, we found significant interactions between adoptive father’s hostility and PDU when predicting children’s problem behaviors, such that higher paternal hostility was associated with higher externalizing and internalizing behaviors for children whose birth mothers were non-use or rare use of illicit drugs during pregnancy. The results suggest that different from non- or rare drug-exposed children, higher levels of PDU may override the effects of paternal hostility, but not maternal hostility, on problem behaviors at Age 7.

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