Sex influence on renal alpha 2-adrenergic receptor density in the spontaneously hypertensive rat.

Gong, Gordon; Dobin, A; McArdle, S; Sun, Lu; Johnson, Mark; Pettinger, William A.

doi:10.1161/01.hyp.23.5.607

Cited by 31 publications

(23 citation statements)

References 30 publications

(35 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Although gender has been shown to influence the status of hypertension in other rat models of the disease [1][2][3], the present study is the first to demonstrate an influence in the 2K1C model. In this study, male 2K1C rats were nearly twice as likely to develop hypertension compared with their female counterparts.…”

Section: Discussioncontrasting

confidence: 56%

A comparison of the development of renal hypertension in male and female rats

OKUNIEWSKI¹,

Davis²,

JARROTT³

et al. 1998

Clinical Science

View full text Add to dashboard Cite

1. The objective of this study was to determine the influence of gender on the development of renal hypertension in Sprague-Dawley rats using the Goldblatt two-kidney, one-clip (2K1C) model. In addition, this study examined the effect of ovariectomy upon the development of hypertension in female rats.2. At 10 weeks of age, male, intact female and ovariectomized female rats underwent clipping of the right renal artery or sham operation. Tail-cuff plethysmography was used to monitor the systolic blood pressure of all animals for 7 weeks post-clipping or sham operation. Rats were sub-grouped according to whether or not they developed hypertension (systolic blood pressure >=150 mmHg).3. Within 2 to 3 weeks of clipping, hypertension was induced in only 53% (n=120) of the intact female 2K1C rats, but in 83% (n=18) of the male and 78% (n=18) of the ovariectomized female rats.4. Seven weeks after right renal artery clipping, plasma renin activity was determined in a subset of each group and was found to be 5-6 fold higher in male (17.29+/-4.04 ng angiotensin I.h-1.ml-1) and ovariectomized female (9.71+/-1.25 ng angiotensin I.h-1.ml-1) hypertensive rats compared with their respective normotensive or sham-operated counterparts (3.39+/-0.58 ng angiotensin I.h-1.ml-1 and 1.60+/-0.41 ng angiotensin I.h-1.ml-1 respectively) (P<0.05, analysis of variance). In contrast, the plasma renin activity measured in intact female hypertensive rats was not significantly different from that measured in the corresponding 2K1C normotensive or sham-operated groups.5. These results indicate that the success rate of inducing renal hypertension in Sprague-Dawley rats is higher in males than in intact females. Furthermore, these results suggest that the induction of 2K1C hypertension may be influenced by ovarian hormones.

show abstract

Section: Discussioncontrasting

confidence: 56%

A comparison of the development of renal hypertension in male and female rats

OKUNIEWSKI¹,

Davis²,

JARROTT³

et al. 1998

Clinical Science

View full text Add to dashboard Cite

show abstract

“…Although the mechanisms responsible for the gender differences in hypertension are not clear, there is significant evidence that androgens such as testosterone play an important role in the gender-specific blood pressure regulation (Reckelhoff, 2001). Indeed, hypertension was reduced by castration in SHR and in Dahl and Sabra salt-sensitive rats (Crofton et al, 1993;Gong et al, 1994;Khalid et al, 2001). Furthermore, administration of androgen receptor antagonist, for 10 days after birth, attenuates the hypertension of male adult SHR, whereas neonatal androgenization of female SHR leads to similar hypertension as that in male (Cambotti et al, 1984).…”

Section: Discussionmentioning

confidence: 99%

Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation

Coatmellec-Taglioni¹,

Dausse²,

Giudicelli³

et al. 2003

J Pharmacol Exp Ther

View full text Add to dashboard Cite

Plasma leptin levels are elevated in obesity suggesting a pathophysiologic role of this hormone in obesity and related disorders, such as hypertension. Furthermore, despite excess leptin levels, leptin satiety action is blunted in obesity suggesting the occurrence of central leptin resistance. As leptin acts on the kidney to induce natriuresis, renal leptin receptor alterations could lead to a defect in sodium excretion and hence to hypertension. Therefore, the present study investigated renal leptin receptor (Ob-Ra and Ob-Rb) mRNA and leptin binding capacities in diet-induced hypertension. Feeding male, female, and testosterone-treated female rats a cafeteria diet for 10 weeks increased body fat mass, plasma insulin, and leptin levels.Furthermore, although male and testosterone-treated female cafeteria-fed rats were hypertensive, the female rats fed the same diet failed to develop elevated blood pressure. In renal medulla, Ob-Ra and Ob-Rb mRNA levels were unchanged after cafeteria diet feeding in all groups; however, binding analysis revealed Ob-R protein down-regulation exclusively in hypertensive rats. Moreover, renal Ob-R densities were inversely correlated to plasma leptin concentrations in male rats and testosterone-treated female rats but not in female rats. These findings demonstrate the existence of differences in renal Ob-R binding capacities, which are correlated to hypertension.

show abstract

“…In addition, ␣ 2B -adrenoceptor densities were markedly increased by the high salt diet. These high levels, which appear to be the consequence of an overexpression of the encoding gene, have also been observed in SHR rats (Gong et al, 1994(Gong et al, , 1995. However, the ␣ 2A -adrenoceptor mRNA was clearly present in kidneys of intact SBH rats under both normal and high salt diet.…”

Section: Discussionmentioning

confidence: 55%

“…Surprisingly, none of the studies mentioned above dealing with the importance of renal ␣ 2 -adrenoceptors in the development of hypertension have considered the possible role of sex. More recently, however, it has been demonstrated that both renal ␣ 2 -adrenoceptor density and blood pressure are influenced by sex in SHR and Wistar Kyoto rats (Gong et al, 1994). In this latter study, it was shown that androgens are needed for the full expression of hypertension as well as for the increase of renal ␣ 2 -adrenoceptor density in SHR rats.…”

mentioning

confidence: 74%

“…Unfortunately, none of the studies mentioned above (Parini et al, 1983;Diop et al, 1984;Le Jossec et al, 1995) have considered the influence of androgens in this genetic form of rodent salt-induced hypertension. Because both renal ␣ 2 -adrenoceptor density and blood pressure are regulated by androgens in SHR rats (Gong et al, 1994), the aim of the present study was to determine whether gonads and testosterone in particular could have any influence on salt-induced high blood pressure, gene expression, and distribution of renal ␣ 2 -adrenoceptor subtypes in the male salt-sensitive Sabra rat.…”

mentioning

confidence: 99%

See 1 more Smart Citation

Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α₂-Adrenoceptor Subtypes

Mostafa¹,

Ilhami²,

Giudicelli³

et al. 2002

J Pharmacol Exp Ther

View full text Add to dashboard Cite

This study investigated the importance of the male sex hormone testosterone on salt-induced hypertension, renal ␣ 2 -adrenoceptor subtype distribution, and gene expression in saltsensitive (SBH) male Sabra rats. Comparisons of blood pressure and renal ␣ 2 -adrenoceptor subtype gene expression and receptor densities have been made among sham-operated rats, and gonadectomized rats treated or not with testosterone and submitted to normal or high salt diet for 6 weeks. In intact rats, only ␣ 2B -adrenoceptors were detected in this rat strain independent of the diet. In these rats, high salt diet increases blood pressure and up-regulates gene expression and density of ␣ 2 -adrenoceptors. Gonadectomy abolishes the hypertensive response to salt overload, decreases gene expression and density of ␣ 2B -adrenoceptors, and prevents their salt-induced up-regulation. After gonadectomy, increased gene expression and a detectable density of ␣ 2A -adrenoceptors are observed at similar levels in normal and high salt diet. In gonadectomized rats, testosterone replacement restores salt-induced hypertension, density of renal ␣ 2B -adrenoceptors, and gene expression to the intact levels observed both under normal and high salt diet. Furthermore, the ␣ 2A -adrenoceptor subtype is not detected in these conditions. If the increase in renal ␣ 2B -adrenoceptor subtypes is indicative of the hypertensive phenotype, the presence of the ␣ 2A -adrenoceptor appears associated with a state of salt resistance in male SBH rats. In conclusion, testosterone is needed for the full expression of salt-induced hypertension in male salt-sensitive Sabra rats. Renal densities of ␣ 2 -adrenoceptor subtypes are under control of the testicles and are differentially regulated by testosterone.

show abstract

Sex influence on renal alpha 2-adrenergic receptor density in the spontaneously hypertensive rat.

Cited by 31 publications

References 30 publications

A comparison of the development of renal hypertension in male and female rats

A comparison of the development of renal hypertension in male and female rats

Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation

Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α₂-Adrenoceptor Subtypes

Contact Info

Product

Resources

About

Sex influence on renal alpha 2-adrenergic receptor density in the spontaneously hypertensive rat.

Cited by 31 publications

References 30 publications

A comparison of the development of renal hypertension in male and female rats

A comparison of the development of renal hypertension in male and female rats

Sexual Dimorphism in Cafeteria Diet-Induced Hypertension Is Associated with Gender-Related Difference in Renal Leptin Receptor Down-Regulation

Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α2-Adrenoceptor Subtypes

Contact Info

Product

Resources

About

Testosterone Dependence of Salt-Induced Hypertension in Sabra Rats and Role of Renal α₂-Adrenoceptor Subtypes