Sex Hormones and Regulation of Host Responses Against Parasites

Alexander, James; Irving, Karen; Snider, Heidi; Satoskar, Abhay R.

doi:10.1007/978-3-642-02155-8_6

Cited by 5 publications

(4 citation statements)

References 220 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Our data show sex influence on survival as after correction for the genome-wide testing significance of the Tbbr loci was detected only in females or in the whole tested group. This observation can be related to the influential role of sex hormones in control of parasitic infections by their ability to modulate different components of both the innate and adaptive immune responses [45] , [46] . Greenblatt and Rosenstreich [47] analyzed resistance of the 10 inbred mouse strains and two sets of F 1 hybrids to infection with T. b. rhodesiense.…”

Section: Discussionmentioning

confidence: 94%

“…This observation can be related to the influential role of sex hormones in control of parasitic infections by their ability to modulate different components of both the innate and adaptive immune responses [45], [46]. Greenblatt and Rosenstreich [47] analyzed resistance of the 10 inbred mouse strains and two sets of F 1 hybrids to infection with T. b. rhodesiense.…”

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

et al. 2011

View full text Add to dashboard Cite

Background Trypanosoma brucei brucei infects livestock, with severe effects in horses and dogs. Mouse strains differ greatly in susceptibility to this parasite. However, no genes controlling these differences were mapped.MethodsWe studied the genetic control of survival after T. b. brucei infection using recombinant congenic (RC) strains, which have a high mapping power. Each RC strain of BALB/c-c-STS/A (CcS/Dem) series contains a different random subset of 12.5% genes from the parental “donor” strain STS/A and 87.5% genes from the “background” strain BALB/c. Although BALB/c and STS/A mice are similarly susceptible to T. b. brucei, the RC strain CcS-11 is more susceptible than either of them. We analyzed genetics of survival in T. b. brucei-infected F2 hybrids between BALB/c and CcS-11. CcS-11 strain carries STS-derived segments on eight chromosomes. They were genotyped in the F2 hybrid mice and their linkage with survival was tested by analysis of variance.ResultsWe mapped four Tbbr (Trypanosoma brucei brucei response) loci that influence survival after T. b. brucei infection. Tbbr1 (chromosome 3) and Tbbr2 (chromosome 12) have effects on survival independent of inter-genic interactions (main effects). Tbbr3 (chromosome 7) influences survival in interaction with Tbbr4 (chromosome 19). Tbbr2 is located on a segment 2.15 Mb short that contains only 26 genes.ConclusionThis study presents the first identification of chromosomal loci controlling susceptibility to T. b. brucei infection. While mapping in F2 hybrids of inbred strains usually has a precision of 40–80 Mb, in RC strains we mapped Tbbr2 to a 2.15 Mb segment containing only 26 genes, which will enable an effective search for the candidate gene. Definition of susceptibility genes will improve the understanding of pathways and genetic diversity underlying the disease and may result in new strategies to overcome the active subversion of the immune system by T. b. brucei.

show abstract

Section: Discussionmentioning

confidence: 94%

Section: Discussionmentioning

confidence: 99%

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

et al. 2011

View full text Add to dashboard Cite

show abstract

“…Other clear sex biases in incidence of disease, parasite burden, pathology, mortality, and immunological response against various parasites, have been observed in humans and in rodents (reviewed in [42]). …”

Section: Discussionmentioning

confidence: 99%

“…These results indicate that data obtained with L. tropica (different sex influence on susceptibility to two relatively closely related pathogen species, sex and genotype interaction, and different sex influence on pathology in different organs) reflect a more general phenomenon. Other clear sex biases in incidence of disease, parasite burden, pathology, mortality, and immunological response against various parasites, have been observed in humans and in rodents (reviewed in [42] ).…”

Section: Discussionmentioning

confidence: 99%

Genetics of Host Response to Leishmania tropica in Mice – Different Control of Skin Pathology, Chemokine Reaction, and Invasion into Spleen and Liver

Kobets

Havelková²,

Grekov³

et al. 2012

PLoS Negl Trop Dis

View full text Add to dashboard Cite

BackgroundLeishmaniasis is a disease caused by protozoan parasites of genus Leishmania. The frequent involvement of Leishmania tropica in human leishmaniasis has been recognized only recently. Similarly as L. major, L. tropica causes cutaneous leishmaniasis in humans, but can also visceralize and cause systemic illness. The relationship between the host genotype and disease manifestations is poorly understood because there were no suitable animal models.MethodsWe studied susceptibility to L. tropica, using BALB/c-c-STS/A (CcS/Dem) recombinant congenic (RC) strains, which differ greatly in susceptibility to L. major. Mice were infected with L. tropica and skin lesions, cytokine and chemokine levels in serum, and parasite numbers in organs were measured.Principal FindingsFemales of BALB/c and several RC strains developed skin lesions. In some strains parasites visceralized and were detected in spleen and liver. Importantly, the strain distribution pattern of symptoms caused by L. tropica was different from that observed after L. major infection. Moreover, sex differently influenced infection with L. tropica and L. major. L. major-infected males exhibited either higher or similar skin pathology as females, whereas L. tropica-infected females were more susceptible than males. The majority of L. tropica-infected strains exhibited increased levels of chemokines CCL2, CCL3 and CCL5. CcS-16 females, which developed the largest lesions, exhibited a unique systemic chemokine reaction, characterized by additional transient early peaks of CCL3 and CCL5, which were not present in CcS-16 males nor in any other strain.ConclusionComparison of L. tropica and L. major infections indicates that the strain patterns of response are species-specific, with different sex effects and largely different host susceptibility genes.

show abstract

Sex Hormones and Immunity to Infection

Klein

Roberts

2010

View full text Add to dashboard Cite

Sex Hormones and Regulation of Host Responses Against Parasites

Abstract: Sex hormones play an influential role in the control of parasitic infection by their ability to modulate different components of both the innate and adaptive immune responses. The parasites themselves are phylogenetically diverse, target a range of different tissues,

Cited by 5 publications

References 220 publications

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

Genetic Control of Resistance to Trypanosoma brucei brucei Infection in Mice

Genetics of Host Response to Leishmania tropica in Mice – Different Control of Skin Pathology, Chemokine Reaction, and Invasion into Spleen and Liver

Sex Hormones and Immunity to Infection

Contact Info

Product

Resources

About