Sex Hormone–Binding Globulin Levels as a Predictor for Developing Gestational Diabetes Mellitus

Association between circulating levels of galanin and pre-pregnancy body mass index in patients with gestational diabetes mellitus

“…The lower level of SHBG is a predictor for the development of obesity, insulin resistance, and type 2 diabetes (Kim & Halter, 2014;Le, Nestler, Strauss, & Wickham, 2012). Also, numerous epidemiological evidences suggested that low level of SHBG may predispose to GDM in pregnant women (Cottrell, Karnitis, & Mobasseri, 2014;Hedderson et al, 2014). Consistent with observations of others studies, a statistically significant lower level of SHBG was found in pregnant women with GDM compared with NGT in this study.…”

Human Sex Hormone-Binding Globulin Binding Affinities of 125 Structurally Diverse Chemicals and Comparison with Their Binding to Androgen Receptor, Estrogen Receptor, and α-Fetoprotein

“…Human SHBG is reported to be associated with many pathological conditions, including endometrial cancer (Nisker et al, 1980), ovarian dysfunction (Hogeveen et al, 2002), breast cancer (Fortunati et al, 2010), nodal metastases (Salonia et al, 2009), prohyperglycemia (Arias-Santiago et al, 2011), preeclampsia (Valdés et al, 2012, osteoporosis (van Pttelgergh et al, 2004;Rapuri et al, 2004), Alzheimer's disease (Muller et al, 2010), diabetes mellitus (Chen et al, 2012;Cottrell et al, 2014), and some cardiovascular diseases (Canoy et al, 2014;Pascual-Figal et al, 2009). Therefore, human SHBG binding data could not only improve human risk assessment of the endocrine disrupting potential of chemicals, but also aid in the development of drugs for the treatment of diseases associated with low endogenous sex hormone bioavailability (Cherkasov et al, 2005a).…”

The first trimester: Prediction and prevention of the great obstetrical syndromes

“…Smirnakis et al (2007) described significantly lower levels of SHBG in pregnancies later affected by GDM (185.1 vs. 255.6 nmol/l), although others have suggested that the wide standard deviation of these distributions mean this will have minimal impact from a screening perspective [93,94]. Other groups have also described a reduction in SHBG levels in pregnancies that go on to develop GDM, reporting 77.3% and 80.0% sensitivity for 43.5% and 84.5% specificity, respectively [95,96]. SHBG levels measured at 13e16 weeks were lower and more highly predictive for GDM requiring insulin therapy (AUC 0.866).…”