Sex Hormone-Binding Globulin is an Independent Predictor of Biochemical Recurrence After Radical Prostatectomy

Waldert, Matthias; Schatzl, Georg; Swietek, Natalia; Rom, Maximilian; Klatte, Tobias

doi:10.1016/j.juro.2012.05.016

Cited by 7 publications

(8 citation statements)

References 29 publications

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“…Many groups have investigated the potential association of sex hormones, mainly T level, and biochemical outcome in men undergoing RP. 6 , 7 , 20 , 22 Although several relevant studies demonstrated that low preoperative T level was associated with higher risk of postoperative BCR, others have reported to the contrary. 23 , 24 In our study, T and free T were not observed to be significant predictor of biochemical outcome following RP.…”

Section: Discussionmentioning

confidence: 99%

“…Analyzing 285 men undergoing RP, Waldert et al observed that preoperative serum SHBG level was independently associated with BCR after RP. 6 They reported that for each 10 U increase in SHBG the risk of BCR increased by 12%. Similar to our findings, T and free T were not associated with BCR in Waldert et al's series.…”

Section: Discussionmentioning

confidence: 99%

“… 11 Previously, from analyzing men undergoing radical prostatectomy (RP) from 2006 to 2007, we reported that serum SHBG level was an independent predictive factor for extraprostatic extension of tumor in patients with clinically localized PCa, a finding also confirmed later in a similar study by others. 6 , 7 , 14 In addition, SHBG has been reported to be associated with lymph node involvement in men undergoing RP. 15 These published data would indicate that SHBG level may well have a role in the prediction of prognosis, at least in patients undergoing RP.…”

Section: Introductionmentioning

confidence: 99%

“…Looking at the literature, not many have reported on the significance of SHBG level on the biochemical outcome after RP. 6 , 7 Thus, we investigated the prognostic significance of preoperative serum SHBG level in patients undergoing RP by analyzing the follow-up data of patients who underwent RP, mostly from our previous study aforementioned. 14 …”

Section: Introductionmentioning

confidence: 99%

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Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy

et al. 2015

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To investigate the significance of preoperative serum sex hormone-binding globulin (SHBG) level regarding the postoperative biochemical outcome in patients who were followed up for relative longer periods after undergoing radical prostatectomy (RP).Preoperative serum levels of testosterone (T), free T, and SHBG level were prospectively analyzed in 307 consecutive patients who underwent RP at our institution between January 2006 and July 2007. We analyzed potential associations of sex hormones with postoperative biochemical recurrence (BCR)-free survival via multivariate Cox proportional regression analysis.Mean postoperative follow-up duration for 307 total patients was 72.1 ± 19.6 months. Kaplan–Meier curve demonstrated that BCR-free survival was significantly worse in patients with higher (≥ 40 ng/mL) SHBG level than others (P < 0.001). Serum T (P = 0.280) and free T (P = 0.606) levels showed no significant association with biochemical outcome. In multivariate analysis encompassing postoperative variables along with PSA, T, and free T, SHBG level (HR 1.825, 1.061–3.138; P = 0.030) was observed to be independently associated with BCR-free survival. Addition of SHBG level to the multivariate model for prediction of BCR-free survival resulted in increased accuracy (83.5% vs. 82.2%; P = 0.164).Our study of patients who were followed up for relative longer periods after RP shows that preoperative serum SHBG level, but not T, is an independent predictor of postoperative BCR-free survival. According to our findings, SHBG measurement may be useful in the selection of candidates for adjuvant treatment following RP.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy

et al. 2015

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“…Our data show an association between circulating levels of serum calcium and SHBG and free estradiol. Both sex steroid hormones have been found to be associated with severity and progression of prostate cancer (35–37). Using 18 prospective studies that included 3886 men with incident prostate cancer, the Endogenous Hormones and Prostate cancer Collaborative Group found an inverse association between serum concentration of SHBG prostate cancer risk (RR in the highest versus lowest fifth: 0.86; 95% CI: 0.75–0.98)(38).…”

Section: Discussionmentioning

confidence: 99%

Association of serum calcium with serum sex steroid hormones in men in NHANES III

et al. 2013

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Background Bone is a positive regulator of male fertility, which indicates a link between regulation of bone remodeling and reproduction or more specifically a link between calcium and androgens. This possibly suggests how calcium is linked to prostate cancer development through its link with the reproductive system. We studied serum calcium and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III). Methods Serum calcium and sex steroid hormones were measured for 1,262 men in NHANES III. We calculated multivariable-adjusted geometric means of serum concentrations of total and estimated free testosterone and estradiol, androstanediol glucuronide (AAG), and sex hormone binding globulin (SHBG) by categories of calcium (lowest 5% [<1.16 mmol/L], mid 90%, top 5% [≥1.30 mmol/L]). Results Levels of total and free testosterone, total estradiol, or AAG did not differ across categories of serum calcium. Adjusted SHBG concentrations were 36.4 for the bottom 5%, 34.2 for the mid 90%, and 38.9 nmol/L for the top 5% of serum calcium (Ptrend=0.006), free estradiol levels were 0.88, 0.92, and 0.80 pg/ml (Ptrend=0.048). Conclusions This link between calcium and sex steroid hormones, in particular the U-shaped pattern with SHBG, may, in part, explain why observational studies have found a link between serum calcium and risk of prostate cancer.

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Serum testosterone improves the accuracy of Prostate Health Index for the detection of prostate cancer

Friedersdorff

Manus

Miller

et al. 2014

Clinical Biochemistry

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Sex Hormone-Binding Globulin is an Independent Predictor of Biochemical Recurrence After Radical Prostatectomy

Cited by 7 publications

References 29 publications

Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy

Preoperative Serum Sex Hormone-Binding Globulin Level Is an Independent Predictor of Biochemical Outcome After Radical Prostatectomy

Association of serum calcium with serum sex steroid hormones in men in NHANES III

Serum testosterone improves the accuracy of Prostate Health Index for the detection of prostate cancer

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