Association of serum calcium with serum sex steroid hormones in men in NHANES III

Hemelrijck, Mieke Van; Michaëlsson, Karl; Nelson, William G.; Kanarek, Norma; Dobs, Adrian S.; Platz, Elizabeth A.; Rohrmann, Sabine

doi:10.3109/13685538.2013.772133

Cited by 5 publications

(7 citation statements)

References 39 publications

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“…The significant difference between prostatic Ca levels before and after puberty allowed us to conclude that in man androgens govern this metal's content of the prostate [12,13]. The relationship between prostatic Ca and androgens was indirectly confirmed in Hemelrijck et al 2013 study serum Ca and sex steroid hormones in the Third National Health and Nutrition Examination Survey (NHANES III) [82]. Thus, the Ca content in normal prostates can possibly depend on the level of androgens.…”

Section: Androgen-dependence Of Prostatic Ca Levelsmentioning

confidence: 86%

A Systematic Review of the Calcium Content of the Normal Human Prostate Gland

Zaichick¹

2021

Iberoam J Med

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Introduction: There is much lack of knowledge concerning most prostatic malfunction, especially the reasons and detailed nature of its pathologies. In spite of advances in medical science, the differential diagnosis of prostatic pathologies has steadily increased in complexity and controversy. A proposal has been made that prostatic calcium (Ca) content determinations may aid in resolving these issues for prostate disorders and especially as an indicator of its carcinoma risk. As a result many measurements of normal prostatic Ca have been made. Materials and methods: Here we analyze data published concerning Ca prostatic levels in healthy subjects. In all 1911 items in the literature of the years dating back to 1921 were identified in the following databases: PubMed, the Cochrane Library, Scopus, Web of Science and ELSEVIER-EMBASE. This data was subject to an analysis employing both the “range” and “median” of means. In this way the disparate nature of published Ca content of normal prostates was evaluated. From the papers examined, 36 were selected for the objective analysis of data from their 1357 healthy patients.. Results: On a wet mass basis prostatic Ca levels spanned the interval from 73 mg/kg to 1280 mg/kg with 360 mg/kg as the median of their means. It is accepted that the prostatic Ca content is contingent on a wide variety of aspects of the host’s milieu, including androgen levels, zone of human prostate sampled, relative amounts of different types of prostatic tissue studied, Ca content of food and drink, Ca supplement intake, age, and the method of analysis. Conclusions: The data encompassed a wide range of values and the sample was small, hence it is advisable that further studies be performed.

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Section: Androgen-dependence Of Prostatic Ca Levelsmentioning

confidence: 86%

A Systematic Review of the Calcium Content of the Normal Human Prostate Gland

Zaichick¹

2021

Iberoam J Med

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“…The reported Intergenerational sex‐specific re‐programming of craniofacial mineralized tissues in offspring in response to maternal Ca/P intake is not fully understood. Ca and P absorption and metabolism are tightly regulated through a complex system, including hormones (calcitonin, parathyroid hormone and sex steroid hormones), vitamins (vitamin D) and other factors (FGF23 and IGF1) 13,32–34 . Insulin‐like growth factor‐1 (IGF1) is known to be a biomarker for pubertal development 35 .…”

Section: Discussionmentioning

confidence: 99%

“…Ca and P absorption and metabolism are tightly regulated through a complex system, including hormones (calcitonin, parathyroid hormone and sex steroid hormones), vitamins (vitamin D) and other factors (FGF23 and IGF1). 13,[32][33][34] Insulin-like growth factor-1 (IGF1) is known to be a biomarker for pubertal development. 35 Previous studies showed that Ca supplementation in pregnant mothers resulted in higher IGF1 levels in boys and lower IGF1 levels in girls during mid-childhood.…”

Section: Upper and Lower Incisors Analysismentioning

confidence: 99%

“…Moreover, previous observational studies reported the presence of a link between serum Ca and the sex steroids hormone. 34 Altogether, altering the maternal Ca/P intake during pregnancy may impact the offspring's dental development via different pathways, including hormones, sex-dependent effects on placental size and function, 37,38 or differences in epigenetic modifications. [39][40][41] The main limitation of our study is that we did not perform pubertal assessments or collect biochemical data to explain the possible mechanism for the sex-specific changes we noticed in the dentition of the offspring.…”

Section: Upper and Lower Incisors Analysismentioning

confidence: 99%

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Altering maternal calcium and phosphorus dietary intake induces persistent sex‐specific changes in the dentition of the offspring

Hassan,

Hassan

et al. 2023

Orthod Craniofacial Res

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BackgroundThe maternal diet is essential to offspring development, but the specific effects on tooth morphology are still unknown. The aim of this study was to evaluate the effects of altering maternal calcium (Ca) and phosphorus (P) supplementation during gestation and lactation on offspring dentition.MethodsPregnant mice were fed an experimental diet containing a threefold increase in Ca and a threefold decrease in P compared to the standard mouse chow diet at embryonic Day 0.5 (E0.5). Offspring mice were maintained on standard or experimental diets from post‐natal Day 0 to weaning, then fed control diets until 6 weeks of age. Six‐week‐old offspring heads were collected and scanned using micro‐computed tomography. Dental morphometrics of offspring maxillary and mandibular first and third molars (n = 5–6 per diet/per sex) were determined. A two‐way ANOVA test was employed to verify the existence of any significant differences between groups. The significance level was set at P < .05.ResultsA two‐way ANOVA revealed a statistically significant interaction between the effects of diet and sex on the upper and lower dentition. Moreover, experimental diet‐fed female offspring exhibited smaller molars with shorter mesiodistal width and larger pulp chambers relative to controls, while experimental diet‐fed male offspring possessed larger molars with wider mesiodistal width and smaller pulp chambers.ConclusionOur findings reveal that altering the maternal and offspring dietary Ca:P ratio during gestation, lactation and weaning led to significant, sex‐specific changes in the offspring dentition. The differences in dentition appeared to be correlated with the sex‐specific changes in the craniofacial skeleton.

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“…The association between Vitamin D and testosterone levels, among others, has been studied by Tak et al [7], Wulaningsih et al [8], Lerchbaum et al [9], Anagnostis et al [10], Bellastella et al [11], and Jorde et al [12]. The effect of TST levels on bone loss has been studied by Barett-Conner et al [13], Yang et al [14], Van Hemelrijck et al [15], and Paller et al [16]. The association between androgen activity and diabetes has been reported by Selvin et al [17].…”

Section: Introductionmentioning

confidence: 99%

Effect of Race/Ethnicity and Smoking on Diurnal Variations in Testosterone Levels

Jain¹

2015

Int Arch Endocrinol Clin Res

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The effect of race/ethnicity and smoking on diurnal variations in total serum testosterone level (T-TST) was evaluated by analyzing data from NHANES for 2011-2012 for adolescent and adult males. For adolescent males, diurnal variability in T-TST levels was substantially smaller among smokers than nonsmokers for non-Hispanic white (NHW) and Hispanics but the reverse was true for non-Hispanic black (NHB). For adult males, morning levels of T-TST were 21-31% higher than the T-TST levels during evening among NHW and there was no diurnal variation in T-TST levels among NHB nonsmokers but NHB smokers had 3%-12% higher T-TST levels during the morning as compared to the evening. Among adolescents, overall, NHW and NHB had statistically significantly higher T-TST levels in the morning as compared to these levels in the evening (p ≤ 0.02). Adult NHW, NHB, and NHAS nonsmokers had statistically significantly lower T-TST levels than NHW, NHB, and NHAS smokers respectively (p ≤ 0.02).

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Association of serum calcium with serum sex steroid hormones in men in NHANES III

Cited by 5 publications

References 39 publications

A Systematic Review of the Calcium Content of the Normal Human Prostate Gland

A Systematic Review of the Calcium Content of the Normal Human Prostate Gland

Altering maternal calcium and phosphorus dietary intake induces persistent sex‐specific changes in the dentition of the offspring

Effect of Race/Ethnicity and Smoking on Diurnal Variations in Testosterone Levels

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