Effect of Race/Ethnicity and Smoking on Diurnal Variations in Testosterone Levels

Jain, Ram B.

doi:10.23937/2572-407x.1510005

Cited by 2 publications

(1 citation statement)

References 35 publications

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“…Fasting status and blood draw time of day (morning, afternoon, and evening) were not standardized across participants. Previous work using the NHANES suggests that fasting status is independently associated with lower testosterone, regardless of time of laboratory draw, and that both age and ethnicity affect diurnal variation 13,14 . To minimize potential confounding from this variability, both fasting status and time of blood draw were included as covariables in the subsequent multivariable analysis.…”

Section: Methodsmentioning

confidence: 99%

The association between guideline‐based exercise thresholds and low testosterone among men in the United States

et al. 2020

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Background Exercise and weight loss have been shown to improve serum testosterone (T) in obese individuals. However, the association between low T levels and guideline‐based exercise thresholds has not been determined. Objective Using the recently updated Physical Activity Guidelines Advisory Committee (PAGAC) recommendations, we sought to investigate the relationship between recommended activity levels and the prevalence of low T levels. Materials and Methods The2011‐2016 National Health and Nutrition Examination Survey (NHANES) was used to identify men ages 18 to 80 years who answered the physical activity questionnaire and underwent serum T testing. Men were categorized based on PAGAC activity level: less than recommended, recommended and greater than recommended. Multivariable logistic regressions were used to determine the association between low T (<300 ng/dL) and activity level across body mass index (BMI) categories while adjusting for potential confounders. Results Of the 7372 men who met the inclusion criteria, the majority (4372, 59.3%) exceeded the recommended amount of activity, whereas only 2326 (31.6%) exercised less than the recommended amount. On multivariable analysis, obese men whose activity exceeded the recommended amount were less likely to have low T (OR 0.523, 95% CI 0.409‐0.669, P < .001) compared with men who did not meet the recommended activity level. Discussion and Conclusions Using a large, nationally representative cohort, we demonstrated that obese men whose activity exceeded PAGAC recommendations had a decreased likelihood of having low T levels. Given the numerous benefits of exercise, these data provide a basis for counseling obese patients regarding the association between exercise and decreased prevalence of low T.

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Section: Methodsmentioning

confidence: 99%

The association between guideline‐based exercise thresholds and low testosterone among men in the United States

et al. 2020

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Characteristics of ulcerated and non‐ulcerated necrobiosis lipoidica

et al. 2022

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Background Necrobiosis lipoidica (NL) is complicated by ulceration in up to 35% of cases. Methods Retrospective study of patients with NL seen at our institution between January 1, 1992, and May 25, 2021, was conducted. Ulcerated NL (UNL, n = 83) and non‐ulcerated NL (NUNL, n = 233) groups were compared. Results Twenty‐six percent (83/316) of patients with NL experienced ulceration. UNL was significantly more likely to be painful (52% vs. 36%, P = 0.01), was more likely to have a lesion‐associated cutaneous malignancy (7% vs. 0%, P < 0.001), and had a larger median size (7 vs. 5 cm, P = 0.004) compared to NUNL. Vascular studies were performed on a subset of patients and revealed transcutaneous oxygen pressure (TcPO2) < 40 mm Hg in 53% and venous insufficiency in 62% with no significant differences between UNL and NUNL groups. In patients with unilateral ulceration, mean TcPO2 values (39.7 vs. 46.6 mm Hg), regional perfusion index <0.6 (29% vs. 14%), and TcPO2 < 40 mm Hg (43% vs. 14%) were worse in the ulcerated leg compared to the non‐ulcerated leg, but these differences were not statistically significant. Conclusions UNL was more likely to be painful, develop lesion‐associated malignancy, and be larger in size compared to NUNL. There were no statistically significant differences in venous insufficiency, arterial Doppler/ankle brachial index, or TcPO2 values between UNL and NUNL patients, however, a significant portion of the cohort demonstrated abnormal vascular studies, particularly on TcPO2 and venous insufficiency testing.

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Effect of Race/Ethnicity and Smoking on Diurnal Variations in Testosterone Levels

Cited by 2 publications

References 35 publications

The association between guideline‐based exercise thresholds and low testosterone among men in the United States

The association between guideline‐based exercise thresholds and low testosterone among men in the United States

Characteristics of ulcerated and non‐ulcerated necrobiosis lipoidica

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