Sex Hormone-Binding Globulin and Serum Testosterone are Inversely Associated with C-Reactive Protein Levels in Postmenopausal Women at High Risk for Cardiovascular Disease

Joffe, Hylton V.; Ridker, Paul M.; Manson, JoAnn E.; Cook, Nancy R.; Buring, Julie E.; Rexrode, Kathryn M.

doi:10.1016/j.annepidem.2005.07.055

Cited by 64 publications

(45 citation statements)

References 35 publications

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“…The low level of SHBG has also been associated with the increase of cardiovascular risk in both pre-and post-menopausal women (Rexrode et al, 2003;Sutton-Tyrrell et al, 2005). In Women's Health Study, SHBG has been inversely related to C-reactive protein in post-menopausal women who had manifested clinical cardiovascular disease (Joffe et al, 2006). Our results did not show a definitive relationship between SHBG and androgen levels, but showed a negative correlation between SHBG and NT-proBNP levels.…”

Section: Discussioncontrasting

confidence: 53%

Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study

et al. 2007

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BACKGROUND: In addition to the negative effect on fertility, polycystic ovary syndrome (PCOS) has been associated with cardiac pathology. Brain natriuretic peptide (BNP) is a possible marker for cardiac risk, therefore we investigated whether N-terminal pro-B-type BNP (NT-proBNP) increases in women with PCOS compared with healthy women of comparable age and body mass index. METHODS: Thirty women with PCOS and 30 healthy women not suffering from overt cardiac disease were involved in the study. Fasting insulin and serum NT-proBNP levels were measured, and M-Mode echocardiography was performed. Insulin resistance was calculated using the homeostasis model assessment insulin resistance index (HOMA-IR). RESULTS: PCOS subjects had higher NT-proBNP levels than the control subjects (P < 0.001). Abnormal echocardiography indices were detected in 14 of the PCOS subjects (but none of the controls), including valvular heart disease in nine, diastolic dysfunction in two, right ventricular enlargement in one, right atrial enlargement in one and pulmonary hypertension in one. PCOS subjects (n = 30) showed an increased left ventricular mass (LVM) (P < 0.001) and left ventricular posterior wall thickness (LVPWT) (P = 0.006). In addition, NT-proBNP concentration was positively correlated with LVM (r = 0.587, P = 0.001) and negatively correlated with sex-hormone-binding globulin (r = 20.528, P = 0.003). There was a positive correlation between LVM and HOMA-IR (r = 0.295, P = 0.03) while LVPWT was positively correlated with fasting insulin and HOMA-IR (r = 0.335, P = 0.031 and r = 0.346, P = 0.045, respectively) in PCOS subjects (n = 30). CONCLUSION: The present study demonstrated that the level of NT-proBNP was increased in PCOS subjects with asymptomatic heart disease.

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Section: Discussioncontrasting

confidence: 53%

Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study

et al. 2007

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“…In many studies in women, plasma estradiol and testosterone have been positively associated with glucose intolerance and insulin resistance, independently of adiposity (11) . Similar association of free testosterone and C-reactive protein have -13-also been reported in women (12) . The purpose of this study was to determine the serum levels of endogenous sex hormones, estrogen and testosterone, as well as hs-CRP in elderly women with and without type 2 diabetes, and to study the association between them.…”

supporting

confidence: 53%

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Draz¹,

Esmayel²,

Mousa³

et al. 2014

Zagazig University Medical Journal

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Background .C-Reactive Protein (CRP), an acute phase reactant has long been considered as a classic marker of inflammation. Ageing is characterized by a chronic, low-grade inflammatory status, the so-called "inflame-ageing". Diabetes is known to be also associated with low-grade inflammation .The normal process of reproductive ageing is characterized by marked hormonal changes, during menopause, estradiol (E2) level decreases dramatically, whereas testosterone level presents a small decline or remain unchanged. A large body of clinical data suggests the important roles of endogenous sex hormones in the pathogenesis of type 2 diabetes. In many studies in women, plasma estradiol and testosterone have been positively associated with glucose intolerance and insulin resistance, independently of adiposity. Objective .The aim of this study was to assess serum levels of endogenous sex hormones (estrogen and testosterone) as well as high sensitive CReactive protein ( hs-CRP) in elderly women with and without type 2 diabetes. Research Design. This study was done in the period between august 2009 to august 2011, The study population included a total number of 60 post menopausal elderly females, 20 healthy non diabetic elderly females as control group and 40 diabetic females. The diabetic females were further divided into two groups according to presence or absence of complications cardiovascular diseaes complicated group and non complicated group. They were also divided into two groups according to glycosylated hemoglobin level (HbA1c) to controlled group and non controlled group. Methods. Total testosterone, total estradiol, hs-CRP and HbA1c were measured in diabetic and non diabetic elderly women. Results. As regard hs-CRP there was a high significant difference between patients(2,2±,56 mg/L) and control group(1.60  0.39 mg/L) and also there was a significant difference between complicated(2.160.51 mg/L) and non complicated group(2.080.76 mg/L) and no significant difference among diabetics whether controlled or non controlled . As regard the serum estradiol, there was a high significant difference between patients (22.513.9 pg/ml) and control group (12.92.71 pg/ml). While there was no significant difference as regard presence or absence of complication and diabetes control. As regard the serum testosterone, there was no significant difference between patients and control group, presence or absence of complication and control of diabetes. Conclusion. In type 2 diabetic postmenopausal elderly women there was significant association between inflammation and serum estradiol while there was no association between inflammation and serum testosterone. As regarding presence or absence of cardiovascular complication and diabetes control neither of two hormones were associated with inflammation.

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“…Androgen involvement related to hypertension is reported in human and animal studies in which increases in testosterone levels are associated with increases in blood pressure (11,18,20,23,34,41). Furthermore, several experimental models of hypertension show that castration reduces hypertension, an effect reversed by testosterone replacement (22).…”

Section: Discussionmentioning

confidence: 99%

Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring

Ojeda¹,

Grigore²,

Yanes³

et al. 2007

American Journal of Physiology-Regulatory, Integrative and Comp

130

178

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Our laboratory uses a model of intrauterine growth restriction (IUGR) induced by placental insufficiency in the rat to examine the developmental origins of adult disease. In this model only male IUGR offspring remain hypertensive in adulthood, revealing sex-specific differences. The purpose of this study was to determine whether testosterone with participation of the renin-angiotensin system (RAS) contributes to hypertension in adult male IUGR offspring. At 16 wk of age a significant increase in testosterone (346 Ϯ 34 vs. 189 Ϯ 12 ng/dl, P Ͻ 0.05) was associated with a significant increase in mean arterial pressure (MAP) measured by telemetry in IUGR offspring (147 Ϯ 1 vs. 125 Ϯ 1 mmHg, P Ͻ 0.05, IUGR vs. control, respectively). Gonadectomy (CTX) at 10 wk of age significantly reduced MAP by 16 wk of age in IUGR offspring (124 Ϯ 2 mmHg, P Ͻ 0.05 vs. intact IUGR) but had no effect in control (125 Ϯ 2 mmHg). A significant decrease in MAP in intact IUGR (111 Ϯ 3 mmHg, P Ͻ 0.05 vs. untreated intact IUGR) and castrated IUGR (110 Ϯ 4 mmHg, P Ͻ 0.05 vs. untreated CTX IUGR) after treatment with enalapril for 2 wk suggests a role for RAS involvement. However, the decrease in blood pressure in response to enalapril was greater in intact IUGR (⌬36 Ϯ 1 mmHg, P Ͻ 0.05) compared with CTX IUGR (⌬15 Ϯ 2 mmHg), indicating an enhanced response to RAS blockade in the presence of testosterone. Thus these results suggest that testosterone plays a role in modulating hypertension in adult male IUGR offspring with participation of the RAS.

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Sex Hormone-Binding Globulin and Serum Testosterone are Inversely Associated with C-Reactive Protein Levels in Postmenopausal Women at High Risk for Cardiovascular Disease

Cited by 64 publications

References 35 publications

Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study

Diagnostic potential of serum N-terminal pro-B-type brain natriuretic peptide level in detection of cardiac wall stress in women with polycystic ovary syndrome: a cross-sectional comparison study

Study of Endogenous Sex Hormones and Inflammation in Elderly Women With Diabetes Mellitus

Testosterone contributes to marked elevations in mean arterial pressure in adult male intrauterine growth restricted offspring

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