Sex Hormonal Action and Chemical Constitution

Schueler, F. W.

doi:10.1126/science.103.2669.221

Cited by 65 publications

(13 citation statements)

References 7 publications

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“…1) have little relationship to the threedimensional configuration of these molecules ; but it was noted from the models that the distances between the C-3 and C-17 carbon atoms of the cyclopentanophenanthrene nucleus and between the C-4 and C-4' carbon atoms of the stilbene nucleus are almost equal. These findings are in agreement with those of Schueler (1946) and Bilbey & Nicol (1963). These similarities appear to be an important factor in the ability of a compound to produce oestrogenic changes in the reproductive tract and stimulation of the RES.…”

Section: Tacesupporting

confidence: 94%

The Effects of Oestrogen: Androgen Interaction on the Reticulo-Endothelial System and Reproductive Tract

Nicol¹,

Vernon‐Roberts²,

Quantock³

1966

Journal of Endocrinology

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1) Oestrone, oestriol, 17\g=b\-oestradiol,ethinyloestradiol, oestradiol monobenzoate, diethylstilboestrol, 4-hydroxy-\g=a\,\g=b\-diethyldibenzyl(HDB), dienoestrol, hexoestrol, triphenylethylene and tri-p-anisylchloroethylene (TACE) stimulated the reticulo-endothelial system (RES) in intact male and in ovariectomized female mice.(2) Testosterone propionate inhibited the vaginal smear response to all the above oestrogenic compounds. It also inhibited the RE stimulation produced by oestrone, oestriol, ethinyloestradiol, oestradiol monobenzoate, triphenylethylene and TACE but had no effect on RE stimulation by diethylstilboestrol, HDB, dienoestrol or hexoestrol; it markedly potentiated the stimulant effect of 17\g=b\-oestradiol on the RES.(3) The effect on the RES of oestrogen : androgen interaction does not appear to be dependent on the type of androgen used.

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Section: Tacesupporting

confidence: 94%

The Effects of Oestrogen: Androgen Interaction on the Reticulo-Endothelial System and Reproductive Tract

Nicol¹,

Vernon‐Roberts²,

Quantock³

1966

Journal of Endocrinology

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“…The pseudoestrogenic effect of certain chemicals has been known for decades [18][19][20][21][22]. However, the reported results showing that endogenous hormones and synthetic EDCs may have caused the sexual disruption of wild life, especially in the treated wastewater discharge area, brought about various further research studies on EDCs [12,23,24].…”

Section: Introductionmentioning

confidence: 90%

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Chang

Choo

Lee

et al. 2009

Journal of Hazardous Materials

342

136

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“…[110][111][112] O livro "Primavera Silenciosa", de autoria de Rachel Carson, publicado em 1962, 113 mostrou de inúmeras formas os efeitos nocivos à saúde humana e aos animais provocados pela exposição ao DDT (dicloro-difenil-tricloroetano). DDT foi determinado em amostras superficiais do Brasil em concentrações entre 6 e 130 ng L -1 , 30,55 e alguns estudos apontam para a possibilidade de afetar as gerações futuras devido ao potencial de bioacumulação deste pesticida.…”

Section: Efeitos Relacionados à Presença De Compostos Interferentes Eunclassified

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

2017

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publicado na web em 11/07/2017 EMERGING CONTAMINANTS IN AQUATIC MATRICES FROM BRAZIL: CURRENT SCENARIO AND ANALYTICAL, ECOTOXICOLOGICAL AND LEGISLATIONAL ASPECTS. Emerging contaminants occur in parts per trillion or less in aquatic matrices. The effects related to the exposure of aquatic biota and human to them have been identified for different compounds. The knowledge about the concentrations of the exposure is the first step to perform risk assessments. The present work describes a literature review about occurrence in Brazilian aquatic matrices, and a discussion about biological effects, legislation and analytical aspects involving the presence of emerging compounds. The review includes 58 papers published between 1997 and 2016, considering the occurrence of personal care and pharmaceutical compounds, illicit drugs, hormones, pesticides and some other endocrine disruptors compounds in the matrices sewage, surface, ground and drinking waters. The concentrations varied from ng L -1 to μg L -1 , depending on the region and the compound. However, the contamination scenario was aggravated by the combination of poor sanitation status -such as low investment in sewage treatment plants, which led to an expressive contamination of the receiving waters with sewage -and the current goods consumption level, which is similar to that of developed countries. These data provide a good insight into the particular levels of contamination and can be used both for further researches and decision making in the regulation area of public policy.Keywords: emerging contaminants; endocrine disruptors compounds; drinking water; surface water; wastewater. CONTAMINANTES EMERGENTESA temática dos contaminantes emergentes ganhou destaque na década passada e vem sendo abordada em diferentes aspectos por pesquisadores do mundo todo. Tratam-se de centenas de compostos que têm sido detectados nos diferentes compartimentos ambientais (solo, água e ar), sendo eles tanto de origem antrópica (presentes em efluentes domésticos, industriais, hospitalares e aqueles provenientes das atividades agrícola e pecuária), quanto de ocorrência natural (presentes em diferentes espécies de plantas, por exemplo). Estes compostos podem apresentar algum risco ao ecossistema e eles não estão incluídos nos programas de monitoramento de rotina, ou seja, não são legislados. Assim, serão candidatos a uma futura regulamentação dependendo dos resultados obtidos em estudos de ecotoxicidade, efeitos à saúde humana, potencial de bioacumulação, transporte e destino nos diferentes compartimentos ambientais, além da quantidade em que são lançados e, portanto, da concentração no ambiente. Tratam-se de estudos que envolvem diferentes áreas da ciência e que têm sido considerados fundamentais para o esclarecimento dos novos paradigmas relacionados ao estilo de vida moderno. Conhecer os riscos associados à exposição por centenas de novos compostos que ainda não estão contemplados nas legislações vigentes permite antecipar e mitigar sérios danos para as gerações futuras.Muitos dos e...

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Sex Hormonal Action and Chemical Constitution

Cited by 65 publications

References 7 publications

The Effects of Oestrogen: Androgen Interaction on the Reticulo-Endothelial System and Reproductive Tract

The Effects of Oestrogen: Androgen Interaction on the Reticulo-Endothelial System and Reproductive Tract

The methods of identification, analysis, and removal of endocrine disrupting compounds (EDCs) in water

Contaminantes emergentes em matrizes aquáticas do Brasil: cenário atual e aspectos analíticos, ecotoxicológicos e regulatórios

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