Sex, Gender, and Orofacial Pain

Shaefer, Jeffry; Khawaja, Shehryar N.; Bavia, Paula Furlan

doi:10.1016/j.cden.2018.06.001

Cited by 52 publications

(44 citation statements)

References 105 publications

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“…Antipsychotics were prescribed to a female patient with schizophrenia. neuralgia) and chronic pain disorder such as fibromyalgia in females [15,19], our results unexpectedly oppose those of previous studies. However, these previous studies are limited to chronic primary headache.…”

Section: Discussioncontrasting

confidence: 99%

Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

Sasaki

Ishii

Maeda

et al. 2020

Journal of Infection and Chemotherapy

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Introduction: There are few studies on sex difference in patients with infectious mononucleosis caused by Epstein-Barr virus (EBV-IM). We performed a retrospective study to evaluate the sex difference in clinical presentation of patients with EBV-IM. Methods: We performed a single-center retrospective study evaluating >14-year-old patients with serologically confirmed EBV-IM during 2006e2017. We compared the patients' age, symptoms, physical findings, and laboratory data between male and female patients. To adjust for confounding factors, we performed a logistic regression analysis based on the results of univariate comparisons. Result: Of the 122 eligible patients (56 male and 66 female, ratio: 1:1.2), the median ages were 26 years old (interquartile range [IR], 22e31.5 years old]) and 22 years old (IR, 20e25 years old) for males and females, respectively (p < 0.001). Headache was significantly more prevalent in males (25.0% vs. 10.6%, p ¼ 0.036). Leukocyte count was also significantly higher in males (11,400/mm 3 [IR, 7,600e14,100/mm 3 ] vs. 9,400/mm 3 [IR, 6,600e11,600/mm 3 ], p ¼ 0.021). The prevalence of periorbital edema (male: 3.6% vs. female: 18.1%, p ¼ 0.012) and severity of transaminase elevation were significantly higher in females. The regression analysis evaluating clinical characteristics of male patients showed that age >30 years old, headache, and leukocyte >11,000/mm 3 had high odds ratios. Conclusion: Our single-center retrospective study suggests that older age of onset, headache, and leukocytosis are more likely to be characteristics of male patients with EBV-IM. Our study also underscores the importance of periorbital edema as a clue for early diagnosis of EBV-IM, especially in female patients.

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Section: Discussioncontrasting

confidence: 99%

Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

Sasaki

Ishii

Maeda

et al. 2020

Journal of Infection and Chemotherapy

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show abstract

“…Analyzing the plurality of factors that may interfere with perceived pain (4), the absence of differences in almost all variables surveyed between the groups in our study seems to contribute to the validation of our findings. It is known that the level of pain correlated with physical stimuli as a result of dental interventions is difficult to determine, since perceived pain depends on an individual threshold and is influenced by emotional, cognitive and cultural factors (24)(25)(26)(27).…”

Section: Discussionmentioning

confidence: 99%

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Pereira¹,

Cota²,

Lima³

et al. 2020

J Clin Exp Dent

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Background: Preemptive analgesia has as its basic principle the administration of analgesics before the onset of painful stimuli, in order to reduce or prevent postoperative pain, but this question is little explored in implantology. Thus, this study was conducted in order to evaluate the clinical efficacy of ibuprofen in pain prevention after unit implant surgery. Material and Methods: For this triple-blind, parallel, placebo-controlled and randomized clinical trial, 54 insertion surgeries of unitary implants were performed. Two groups have received two different protocols 1 hour before surgery: Ibuprofen group (IBU) 600 mg of ibuprofen; and (2) placebo group (maize starch). The intensity of the pain was evaluated through the visual analogue scale (VAS) in 6 times (1, 6, 12, 24, 48 and 72 hours after the surgery). Patients were instructed to take 750 mg of paracetamol as rescue medication, if necessary. The occurrence and the intensity of pain were analyzed by means of an analysis of variance ANOVA with repeated measurements using the general linear model procedure. Results: The IBU group had significantly lower VAS scores overall (IBU = 0.30, ± 0.57; placebo = 1.14, ± 1.07; p<0.001) and at all times in the intra, intergroup comparisons and time/group interaction than the placebo group (p< 0.001). The use of rescue medication was significantly lower and the postoperative time was longer in the IBU group compared to placebo (p = 0.002). Conclusions: The single use of ibuprofen was found to be significantly superior in reducing pain after unit implant surgery compared to placebo.

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“…The main sources of orofacial pain are odontogenic problems, headache, neurogenic disorders, musculoskeletal pain, psychogenic pain, cancer, infection, autoimmune phenomena, and tissue trauma. 1 This problem may have biological repercussions and impact the quality of life of affected individuals. Patients may exhibit physiological dysfunctions, leading to a higher intake of medications, sleep disorders, dietary changes, and leave of absence from work.…”

Section: Introductionmentioning

confidence: 99%

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

et al. 2020

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We aimed to evaluate the orofacial antinociceptive effect of geraniol in mice and its molecular anchorage mechanism. Seven mice per group (probabilistic sample) were treated with geraniol (12.5, 25 and 50 mg/kg, i.p.), morphine (6 mg/kg, i.p.) and vehicle (saline + Tween 80 at 0.2%, i.p.) 30 minutes prior to the beginning of the experiment. Injecting glutamate (25 μM), capsaicin (2.5 μg) and formalin (2%) into the right upper lip (perinasal) of the mouse induced nociception. Behavioral analysis of the animals considered the friction time (in seconds) of the mentioned region using hind or front paws by a researcher blinded to the treatment groups. The statistical analysis was performed blindly, considering α = 5%. The results showed that in the glutamate and capsaicin tests, concentrations of 25 mg/kg and 50 mg/ kg presented antinociceptive activity (p < 0.005, power> 80%). In the formalin test, geraniol was able to reduce nociception at a concentration of 50 mg/kg (p < 0.005, power> 80%). In the molecular anchorage study, high values of binding between the evaluated substance and receptors of glutamate were observed (metabotropic glutamate receptor,-87.8501 Kcal/mol; N-methyl-D-aspartate,-86.4451 Kcal/mol; α-amino-3hydroxy-5-methyl-4-isoxazole propionic acid,-85.6755 Kcal/mol). Geraniol presented orofacial antinociceptive activity, probably by interacting with glutamate-related receptors.

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Sex, Gender, and Orofacial Pain

Cited by 52 publications

References 105 publications

Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

Sex difference in clinical presentation of patients with infectious mononucleosis caused by Epstein-Barr virus

Effect of preemptive analgesia with ibuprofen in the control of postoperative pain in dental implant surgeries: A randomized, triple-blind controlled clinical trial

Orofacial antinociceptive activity and anchorage molecular mechanism in silico of geraniol

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