Sex Disparity in Survival of Patients With Uveal Melanoma: Better Survival Rates in Women Than in Men in South Korea

Park, San Jun; Oh, Chang‐Mo; Yeon, Bong; Cho, Hyunsoon; Park, Kyu Hyung

doi:10.1167/iovs.16-20077

Cited by 8 publications

(8 citation statements)

References 32 publications

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“…A recent study in 344 South Korean UM patients reported higher survival probabilities in females. 36 Several explanations can be proposed for the observed association of male gender with poor survival in our study, which was evident in the total cohort, as well as after 5 years of follow-up, in our competing risks regression analysis. One possibility is that males have larger and more advanced primary tumors than females, as described in some but not all reports.…”

Section: Discussionmentioning

confidence: 51%

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Prognostic Factors Five Years After Enucleation for Uveal Melanoma

Doğrusöz

Brouwer

Geus

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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A subgroup of uveal melanoma (UM) gives rise to metastases at a late stage. Our objective was to identify patient and tumor characteristics that are associated with UM-related death in patients who survived 5 years following enucleation. METHODS. A retrospective analysis was performed in 583 primary UM cases, enucleated at the Leiden University Medical Center between 1983 and 2013. Univariable and multivariable Cox regression analyses were performed in the total cohort and separately in those surviving more than 5 years (n = 297). RESULTS. In the total cohort, the median age was 62.6 years, and the median tumor diameter was 12.0 mm. Monosomy 3 was detected in 53% of cases and gain of 8q in 47%. In the cohort surviving 5 years, the median age was 59.5 years, and the median tumor diameter was 11.0 mm. Monosomy 3 and gain of 8q were detected in 33% and 31% of cases, respectively. In the total cohort, male gender (P = 0.03), tumor diameter (P < 0.001), mitotic count (P < 0.001), extravascular matrix loops (P = 0.03), extraocular growth (P < 0.001), and gain of 8q (P < 0.001) were independently associated with UM-related death. In patients surviving 5 years after enucleation, univariable analysis revealed that age (P = 0.03), tumor diameter (P < 0.001), monosomy 3 (P = 0.04), and 8q gain (P = 0.003) were associated with subsequent UM-related death. Using a multivariable analysis, only male gender (P = 0.03) and gain of 8q (P = 0.01) remained significant. CONCLUSIONS. Predictors of UM-related death change over time. Among UM patients who survived the initial 5 years following enucleation, male gender and chromosome 8q status were the remaining factors related to UM-related death later on.

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Section: Discussionmentioning

confidence: 51%

“…A recent study in 344 South Korean UM patients reported higher survival probabilities in females. 36 …”

Section: Discussionmentioning

confidence: 99%

Prognostic Factors Five Years After Enucleation for Uveal Melanoma

Doğrusöz

Brouwer

Geus

et al. 2020

Invest. Ophthalmol. Vis. Sci.

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“…26 27 Others showed consistent results. 28 The high SIR of diagnosing patients in FiPUM group can be an indicator of the physicians' concern about the metastasis of UM to other sites and their meticulous examination of patients thereafter. While examining the fundus of is not indicated in most of the guidelines of the malignancies elsewhere in the body resulting in failure to find early UM.…”

Section: Discussionmentioning

confidence: 99%

Uveal melanoma-associated cancers revisited

et al. 2020

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BackgroundUveal melanoma (UM) is the most common primary ocular malignancy of adults. A small group of patients was found to express familial predisposition. Moreover, it may be preceded or followed by other malignancies elsewhere in the body. We aim to compare the incidence of UM and other associated cancers and study the factors that may influence each condition.Patients and methodsWe have collected the data from the Surveillance, Epidemiology and End Results database of nine US cancer registries for UM patients between 1973 and 2015. We calculated the standardised incidence ratios for single primary UM, first primary and second primary UM, and compared the groups for multiple factors.ResultsA total of 4946 patients were included in the study; 3863 with single primary UM, 646 developed a second primary malignancy following UM, and 437 patients developed second primary UM following a previous primary malignancy. The risk of developing UM increased after leukaemia, melanoma of the skin and prostate. On the other side, the risk of developing melanoma of the skin, thyroid, renal and other eye and orbit malignancies has increased significantly after initial UM. This risk was more evident in the age group between 50 and 70 years old. Cancer-specific survival was significantly higher in UM associated with other malignancies group compared with single primary UM.ConclusionOur study showed a different behaviour of the UM when associated with other tumours that exceed the known spectrum of hereditary UM. Further studies are required to dissect the genetic background of this behaviour.

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“… 21 , 23 The pattern is however not apparent in the articles by Zloto et al 2013 and Park et al 2017. 16 , 17 Park et al reported a relatively short mean follow‐up of 5.4 years. Zloto et al described a two‐fold excess of male melanoma‐related mortality in the first 10 years after diagnosis but did not report median follow‐up for survivors or how many of their patients remained in their data after the first decade.…”

Section: Discussionmentioning

confidence: 99%

“… 13 , 14 , 15 Male sex has also been identified as an independent predictor of metastasis and UM‐related death within the first decade after diagnosis. 16 , 17 , 18 , 19 Notably, other large randomized studies or retrospective cohort studies with longer follow‐up have failed to identify sex‐based differences in survival rates. 20 , 21 , 22 , 23 Some observations even indicate that young women have a relatively worse prognosis than young men.…”

Section: Introductionmentioning

confidence: 99%

Sex‐based differences in early and late uveal melanoma‐related mortality

Stålhammar

2022

Cancer Medicine

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Background It is debated if there are sex‐based differences in survival for patients with uveal melanoma. Previous observations of higher mortality for men in studies with <10‐year follow‐up have not been replicated in studies with longer follow‐up. It is therefore hypothesized that women have a worse survival in later periods. Methods All patients diagnosed with primary uveal melanoma in Sweden between 1980 and 2017 were included ( n = 2032). Survival differences between men and women in early (<10 years from diagnosis) and late (≥10 years) periods were analyzed. Results At baseline, there were no significant differences in mean patient age, tumor thickness, diameter, ciliary body involvement, primary treatment modality, or in American Joint Committee on Cancer (AJCC) T‐category between men and women. In total, 764 patients (425 women and 339 men) survived and were followed ≥10 years. In this group, men were significantly younger, but there were no differences in baseline tumor thickness, diameter, ciliary body involvement, primary treatment, or AJCC T‐category. In competing risk analysis, women had higher incidence of uveal melanoma‐related mortality in the late period ( p = 0.036). In univariate Cox regression, male (HR 1.2, p = 0.049) and female sex (HR 1.8, p = 0.034) were significant predictors of uveal melanoma‐related mortality in the early and late periods, respectively. Conclusion Women with uveal melanoma have better survival in the first decade after diagnosis. Thereafter, female survivors are significantly older than men and have a higher incidence of uveal melanoma‐related mortality.

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Sex Disparity in Survival of Patients With Uveal Melanoma: Better Survival Rates in Women Than in Men in South Korea

Cited by 8 publications

References 32 publications

Prognostic Factors Five Years After Enucleation for Uveal Melanoma

Prognostic Factors Five Years After Enucleation for Uveal Melanoma

Uveal melanoma-associated cancers revisited

Sex‐based differences in early and late uveal melanoma‐related mortality

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