<scp>Sex‐based</scp> differences in early and late uveal melanoma‐related mortality

Stålhammar, Gustav

doi:10.1002/cam4.5458

Cited by 4 publications

(2 citation statements)

References 54 publications

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“…In men, tumors tended to be larger and more posterior than in women. Men suffered more metastases, and their mortality rate was also higher than in women (in studies with less than 10 years of follow-up) [ 13 , 17 , 18 , 19 , 20 ].…”

Section: Introductionmentioning

confidence: 99%

Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients

Romanowska–Dixon

Dębicka-Kumela

Śmigielski

et al. 2023

JPM

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(1) Background: The aim of this study was to analyze the sex differences in the treatment of uveal melanoma (UM) in a group of 1336 patients from a national referral center during the period 2018–2021. (2) Materials and Methods: The study was designed in a retrospective manner. A total of 1336 patients who were newly diagnosed with UM at the Department of Ophthalmology and Ophthalmic Oncology, Jagiellonian University Collegium Medicum, Krakow, Poland, between 1 January 2018 and 31 December 2021, were included in the study. The demographic and clinical data were compiled, including the sex of patients and the treatment methods. (3) Results: In total, 1336 patients with ocular melanoma were identified, including 726 women (54.34%) and 610 men (45.66%). A total of 49.70% of tumors were localized in the right eye and 50.30% in the left eye. UMs were localized statistically significantly more frequently posterior to the equator of the eye globe in men than in women (79.67% vs. 74.10%, Chi^2 Pearson test p = 0.035). Tumors tended to be larger in men, but this difference was not clinically significant. Men were enucleated more often than women (23.44% vs. 18.04%, Chi^2 Pearson test p = 0.015). (4) Conclusions: Statistically significant sex differences were found in the treatment of uveal melanoma in a national referral center in Poland, with men being enucleated more often than women.

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Section: Introductionmentioning

confidence: 99%

Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients

Romanowska–Dixon

Dębicka-Kumela

Śmigielski

et al. 2023

JPM

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“…Advanced age is a significant prognostic factor in UM, with a positive association between age and the risk of metastasis. This phenomenon may be attributed, at least in part, to a lead time bias, where older patients are more likely to have larger tumors that have been growing for an extended period [ 94 ].…”

Section: Resultsmentioning

confidence: 99%

Differences and Similarities in Epidemiology and Risk Factors for Cutaneous and Uveal Melanoma

Brănișteanu,

Porumb-Andrese,

Stărică

et al. 2023

Medicina

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Both cutaneous melanoma (CM) and uveal melanoma (UM) represent important causes of morbidity and mortality. In this review, we evaluate the available knowledge on the differences and similarities between cutaneous melanoma and uveal melanoma, focusing on the epidemiological aspects and risk factors. Uveal melanoma is a rare condition but is the most prevalent primary intra-ocular malignant tumor in adults. Cutaneous melanoma, on the other hand, is significantly more common. While the frequency of cutaneous melanoma has increased in the last decades worldwide, the incidence of uveal melanoma has remained stable. Although both tumors arise from melanocytes, they are very distinct entities biologically, with complex and varied etiologies. Both conditions are encountered more frequently by individuals with a fair phenotype. ultraviolet-radiation is an important, well-documented risk factor for the development of CM, but has shown not to be of specific risk in UM. Although cutaneous and ocular melanomas seem to be inherited independently, there are reported cases of concomitant primary tumors in the same patient.

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Association of female sex with cataract surgery in the general population but not in plaque brachytherapy-treated uveal melanoma patients

Hagström,

Sabazade,

Gill

et al. 2024

Sci Rep

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Cataract is a leading cause of blindness worldwide, necessitating a deeper understanding of its risk factors. We analyzed two cohorts: 1000 individuals from the general Swedish population and 933 patients who received plaque brachytherapy for uveal melanoma. Using Kaplan-Meier and cumulative incidence analyses, as well as Cox and competing risk regressions, we assessed whether there is a relationship between sex and cataract surgery. In the general population, female sex was a significant risk factor for cataract surgery, with a 10-year incidence of 16% compared to 10% for males (subdistribution hazard ratio adjusted for age, 1.35, P < 0.001). In the brachytherapy cohort, female sex was not associated with an increased incidence of cataract surgery, with a 10-year incidence of 25% versus 23% for males (HR 1.08, P = 0.61). Visual acuity at the time of cataract surgery did not significantly differ between sexes in either cohort, suggesting that differences in surgery rates are not due to health-seeking behavior or surgery assessment thresholds. These findings indicate that female sex is associated with a higher risk of cataract surgery in the general population, but not among those treated with plaque brachytherapy for uveal melanoma.

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Sex‐based differences in early and late uveal melanoma‐related mortality

Cited by 4 publications

References 54 publications

Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients

Sex Differences in the Treatment of Uveal Melanoma in a Group of 1336 Patients

Differences and Similarities in Epidemiology and Risk Factors for Cutaneous and Uveal Melanoma

Association of female sex with cataract surgery in the general population but not in plaque brachytherapy-treated uveal melanoma patients

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