Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Du, Yan; Xiao-dong, Wang; Xie, Hua; Zheng, Songbai; Wu, Xiongfei; Zhu, Xiaoying; Zhang, Xuemei; Xue, Shimin; Li, Huilin; Hong, Wei; Tang, Wenjing; Chen, Minmin; Cheng, Qun; Sun, Jiao

doi:10.1186/s12902-019-0432-x

Cited by 109 publications

(119 citation statements)

References 43 publications

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“…The high proportion of sarcopenia among the males is consistent with reports from other studies[ 10 , 19 , 21 ]–[ 23 ]. However predisposition for sarcopenia was noted among women during post-menopausal period compared to men explained by the decrease in concentrations of sex steroids, both estrogens and androgens after menopause[ 23 ]–[ 25 ]. On the contrary, even among the elderly, the present study showed a significantly higher proportion of LSMI sarcopenia among men.…”

Section: Discussionsupporting

confidence: 92%

Prevalence and associated factors of sarcopenia among patients underwent abdominal CT scan in Tertiary Care Hospital of South India

Sreepriya

Pillai

Nair

et al. 2020

JFSF

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The term sarcopenia is derived from the Greek meaning 'poverty of flesh' and is characterized by the progressive loss of skeletal muscle mass, muscle strength, and physical performance. This term was first coined by I.H. Rosenberg to denote "ageing related loss of skeletal muscle mass and strength" 1. Sarcopenia has a biological component with the genes involved in skeletal muscle mitochondrial function, oxidative capacity, and glucose uptake showing reduced expression with ageing 2. It affects women and men equally, starting from the fourth decade and accelerating from the 6 th decade 3. It was originally described in the elderly population, and is often now defined as a geriatric syndrome associated with functional impairment, increased risk of falls, fractures, and reduced survival. Sarcopenia has been found to be a predictor of chronic disease progression, poorer functional outcomes, and postoperative complications (both infections and noninfectious complications) 4. Standardization of sarcopenia assessment, especially in diagnosis of low muscle mass, will be crucial for clinical practice and interventions in the future. Dual energy X-ray absorptiometry (DEXA), bioelectrical impedance analysis Abstract Objective: To estimate the proportion of radiologically significant (LSMI) sarcopenia and the factors associated with it among patients undergoing Computerized Tomography scan. Methods: A Cross sectional study was conducted among 152 patients underwent CT scan in the radiology department of Government medical college Thiruvananthapuram. Sarcopenia was estimated based on lumbar skeletal muscle index obtained using cross sectional areas of various abdominal muscles by CT scan. The proportion of sarcopenia was estimated and associated factors studied. Binary logistic regression model was used to adjust the confounders. Results: Out of 152 individuals, sarcopenia was present in a total of 82 (53.95%) individuals. Male gender (Adjusted OR= 8.42, 3.64-19.52 (95% CI)) was a risk factor for and a body mass index more than 25Kg/m 2 (Adjusted OR= 0.36, 0.15-0.67 (95% CI)) was a protective factor against sarcopenia. Conclusion: The burden of sarcopenia is found to be high and considering the double burden of sarcopenia and obesity in the Kerala community, newer strategies for health promotion and early detection need to be developed.

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Section: Discussionsupporting

confidence: 92%

Prevalence and associated factors of sarcopenia among patients underwent abdominal CT scan in Tertiary Care Hospital of South India

Sreepriya

Pillai

Nair

et al. 2020

JFSF

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“…The data regarding sex as a risk factor for sarcopenia remain controversial. Sarcopenia more commonly occurred in males than females in some studies 13,[32][33][34] . Previous study showed that muscle mass deterioration in elderly males was faster than elderly females 35 .…”

Section: Discussionmentioning

confidence: 97%

Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study

Therakomen

Petchlorlian

Lakananurak

2020

Sci Rep

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No previous study has investigated the prevalence and risk factors for primary sarcopenia in outpatient setting. This study aims to evaluate the prevalence and factors associated with primary sarcopenia in outpatient elderly. Additionally, we compared the severity of sarcopenia based on the 2014 and 2019 Asian Working Group for Sarcopenia (AWGS) criteria. This cross-sectional study was performed in 330 subjects aged over 60 years in an outpatient setting. The muscle strength, muscle performance and muscle mass were assessed using the handheld dynamometer, 6-m gait speed, and bioelectrical impedance analysis, respectively. The prevalence of sarcopenia was 10% as per the 2014 and 2019 AWGS criteria. The development of sarcopenia was positively correlated with the age with an odds ratio (OR) of 6.87 [95% confidence interval (CI) 1.63–28.88] in the middle-old group (70–79 years), and 13.71 (95%CI 3.66–51.41; p = 0.009) in the very old group (≥ 80 years). Prefrailty and low physical activity were significantly associated with sarcopenia with an OR of 4.75 (95%CI 1.90—11.89) in prefrailty, 15.35 (95%CI 1.69–139.47) in the middle activity group, and 17.99 (95%CI 1.95–165.73) in the lowest activity group. In conclusion, primary sarcopenia was found in one-tenth of outpatient elderly. Age, prefrailty, and low activity were independent factors associated with sarcopenia.

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“…Previous studies showed that prevalence of sarcopenia was significantly higher in male compared with female. 21 22 There has been evidence that the rate of skeletal muscle loss was accelerated in men compared with women. 23 24 Sex hormones may contribute to this difference.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of sarcopenia and its associated factors in patients attending geriatric clinics in Vietnam: a cross-sectional study

Nguyen

et al. 2020

BMJ Open

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ObjectivesThis study aims to investigate the prevalence of sarcopenia and its associated factors in patients attending geriatric clinics in Vietnam.Design and settingA cross-sectional study was conducted in consecutive patients aged ≥60 visiting outpatient clinics of the National Geriatric Hospital in Hanoi, Vietnam, from January 2018 to October 2018. Handgrip strength was measured with a hand dynamometer. Whole-body dual-energy X-ray absorptiometry was applied to measure the appendicular skeletal muscle mass. Sarcopenia was defined by the criteria proposed by the Asian Working Group for Sarcopenia (AWGS 2019) and by the Foundation for the National Institutes of Health (FNIH) Sarcopenia Project.ResultsThere were 600 participants, mean age 70.0±8.0, 60.8% female. The prevalence of sarcopenia was 54.7% according to AWGS 2019 criteria and 40.5% according to FNIH. In multivariate logistic regression, age (adjusted OR 1.08, 95% CI 1.05 to 1.11), male (adjusted OR 2.03, 95% CI 1.29 to 3.21), underweight (adjusted OR 2.32, 95% CI 1.22 to 4.41), being malnourished (adjusted OR 3.77, 95% CI 1.19 to 11.91), chronic lung diseases (adjusted OR 3.48, 95% CI 2.10 to 5.77) and lower physical activity were significantly associated with sarcopenia defined by AWGS 2019 criteria. With FNIH definition, the significantly associated factors were age (adjusted OR 1.07, 95% CI 1.04 to 1.11), male (adjusted OR 6.78, 95% CI 4.12 to 11.17), low education (adjusted OR 2.15, 95% CI 1.27 to 3.63), being malnourished (adjusted OR 3.35, 95% CI 1.28 to 8.76), chronic lung diseases (adjusted OR 2.58, 95% CI 1.56 to 4.28) and lower physical activity level.ConclusionThe prevalence of sarcopenia in patients attending geriatric clinics was high. Further studies are needed to examine the impact of sarcopenia on adverse outcomes in this population.

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Sex differences in the prevalence and adverse outcomes of sarcopenia and sarcopenic obesity in community dwelling elderly in East China using the AWGS criteria

Cited by 109 publications

References 43 publications

Prevalence and associated factors of sarcopenia among patients underwent abdominal CT scan in Tertiary Care Hospital of South India

Prevalence and associated factors of sarcopenia among patients underwent abdominal CT scan in Tertiary Care Hospital of South India

Prevalence and risk factors of primary sarcopenia in community-dwelling outpatient elderly: a cross-sectional study

Prevalence of sarcopenia and its associated factors in patients attending geriatric clinics in Vietnam: a cross-sectional study

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