Prevalence and associated factors of sarcopenia among patients underwent abdominal CT scan in Tertiary Care Hospital of South India

Abstract

The term sarcopenia is derived from the Greek meaning 'poverty of flesh' and is characterized by the progressive loss of skeletal muscle mass, muscle strength, and physical performance. This term was first coined by I.H. Rosenberg to denote "ageing related loss of skeletal muscle mass and strength" 1. Sarcopenia has a biological component with the genes involved in skeletal muscle mitochondrial function, oxidative capacity, and glucose uptake showing reduced expression with ageing 2. It affects women and men equally, starting from the fourth decade and accelerating from the 6 th decade 3. It was originally described in the elderly population, and is often now defined as a geriatric syndrome associated with functional impairment, increased risk of falls, fractures, and reduced survival. Sarcopenia has been found to be a predictor of chronic disease progression, poorer functional outcomes, and postoperative complications (both infections and noninfectious complications) 4. Standardization of sarcopenia assessment, especially in diagnosis of low muscle mass, will be crucial for clinical practice and interventions in the future. Dual energy X-ray absorptiometry (DEXA), bioelectrical impedance analysis Abstract Objective: To estimate the proportion of radiologically significant (LSMI) sarcopenia and the factors associated with it among patients undergoing Computerized Tomography scan. Methods: A Cross sectional study was conducted among 152 patients underwent CT scan in the radiology department of Government medical college Thiruvananthapuram. Sarcopenia was estimated based on lumbar skeletal muscle index obtained using cross sectional areas of various abdominal muscles by CT scan. The proportion of sarcopenia was estimated and associated factors studied. Binary logistic regression model was used to adjust the confounders. Results: Out of 152 individuals, sarcopenia was present in a total of 82 (53.95%) individuals. Male gender (Adjusted OR= 8.42, 3.64-19.52 (95% CI)) was a risk factor for and a body mass index more than 25Kg/m 2 (Adjusted OR= 0.36, 0.15-0.67 (95% CI)) was a protective factor against sarcopenia. Conclusion: The burden of sarcopenia is found to be high and considering the double burden of sarcopenia and obesity in the Kerala community, newer strategies for health promotion and early detection need to be developed.

Prevalence and factors contributing to primary sarcopenia in relatively healthy older Indians attending the outpatient department in a tertiary care hospital: A cross‐sectional study

“…An Indian hospital‐based study published in 2020 which looked at computerized tomogram assessment of sarcopenia showed men were eight times more likely to be sarcopenic than women. 21 Similar findings were reported from a Chinese community study (19.2% men vs 8.6% women). 22 Possible reasons include the rapid decline in muscle mass due to age‐dependent reduction in testosterone and insulin‐like growth factor‐1 levels in men.…”

Prediction of abdominal CT body composition parameters by thoracic measurements as a new approach to detect sarcopenia in a COVID-19 cohort

“…For example, Iannuzzi-Sucich et al who assessed sarcopenia by BIA and clinical testing in a healthy older population, found men to be sarcopenic 4% more often than women, a discrepancy which increased in the age cohort of those over 80 years 42 . Similarly, higher rates of sarcopenic male patients have been described in some CT based body composition studies 43 , 44 . However, it should be noted that contradictory study results with a slightly higher sarcopenia prevalence among women have also been published 45 and that the patient number of this study’s collective was limited.…”

Prevalence and determinants of sarcopenia in Indian patients with chronic kidney disease stage 3 & 4

“…In a multicontinental study involving a healthy elderly population, 17.5% of Indians had sarcopenia, a considerably higher figure than other Asian countries and Europe [ 17 ]. Similarly, a hospital-based study from South India reported a sarcopenia prevalence of 54% among older adults who underwent imaging for non-malignant indications [ 18 ].…”