Sex Differences in the Metabolism of Ethanol and Acetaldehyde in Normal Subjects

Arthur, M. J. P.; Lee, A.; Wright, Robert E.

doi:10.1042/cs0670397

Cited by 69 publications

(25 citation statements)

References 21 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…These differences in drinking habits might explain the lower incidence of several alcohol-related diseases in women than in men 33,34 . Nevertheless, despite this, for equal alcohol intake, women have higher blood levels of ethanol than men 35,36 and ethanol bioavailability is much greater in women than men because women have lower gastric alcohol dehydrogenase activity 22 and the volume of distribution of ethanol is also lower 37 . Another finding of our study was that European centres differed in the distribution of alcohol consumption during the week and whether or not it was consumed mainly at mealtimes.…”

Section: Discussionmentioning

confidence: 99%

Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project

Sieri¹,

Agudo

Kesse

et al. 2002

Public Health Nutr.

119

112

View full text Add to dashboard Cite

Abstractbjective:The aim of this study was to compare the quantities of alcohol and types of alcoholic beverages consumed, and the timing of consumption, in centres participating in the European Prospective Investigation into Cancer and Nutrition (EPIC). These centres, in 10 European countries, are characterised by widely differing drinking habits and frequencies of alcohol-related diseases.Methods:We collected a single standardised 24-hour dietary recall per subject from a random sample of the EPIC cohort (36 900 persons initially and 35 955 after exclusion of subjects under 35 and over 74 years of age). This provided detailed information on the distribution of alcohol consumption during the day in relation to main meals, and was used to determine weekly consumption patterns. The crude and adjusted (by age, day of week and season) means of total ethanol consumption and consumption according to type of beverage were stratified by centre and sex.Results:Sex was a strong determinant of drinking patterns in all 10 countries. The highest total alcohol consumption was observed in the Spanish centres (San Sebastian, 41.4 g day−1) for men and in Danish centres (Copenhagen, 20.9 g day−1) for women. The lowest total alcohol intake was in the Swedish centres (Umeå, 10.2 g day−1) in men and in Greek women (3.4 g day−1). Among men, the main contributor to total alcohol intake was wine in Mediterranean countries and beer in the Dutch, German, Swedish and Danish centres. In most centres, the main source of alcohol for women was wine except for Murcia (Spain), where it was beer. Alcohol consumption, particularly by women, increased markedly during the weekend in nearly all centres. The German, Dutch, UK (general population) and Danish centres were characterised by the highest percentages of alcohol consumption outside mealtimes.Conclusions:The large variation in drinking patterns among the EPIC centres provides an opportunity to better understand the relationship between alcohol and alcohol-related diseases.

show abstract

Section: Discussionmentioning

confidence: 99%

Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project

Sieri¹,

Agudo

Kesse

et al. 2002

Public Health Nutr.

119

112

View full text Add to dashboard Cite

show abstract

“…The rate of elimination in breath is 0.07 mg/l/h on average [14,18]. Since the 1980s, it has been discussed that women are able to eliminate alcohol significantly faster than men and the causes for this phenomenon have been intensely disputed [2,5,17,23,[26][27][28].…”

Section: Introductionmentioning

confidence: 98%

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

et al. 2008

View full text Add to dashboard Cite

As elimination rates for alcohol are suggested to be gender specific, a novel regression model has been applied to estimate these rates for both men and women using experimentally measured data from 81 female and 96 male volunteers described in previous papers. Breath alcohol measurements were done with the Alcotest 7110 Evidential device and were coupled with concomitant sampling of venous blood. Statistical analyses involved use of a mixed linear model for blood alcohol concentration (BAC) and breath alcohol concentration (BrAC), respectively. The model takes regression lines for each test subject into account with an individual starting value (2 h after the end of drinking) and with an individual alcohol elimination rate per hour (coincidental effects). Further, the data was modeled so that an average alcohol elimination rate per hour could be estimated separately for both genders (constant effects). This enables us to methodically correctly estimate the back calculation. The elimination rates beta (60), which can be used for minimum and maximum back calculations for the BAC, were 0.115 g/kg/h and 0.260 g/kg/h, respectively, for women and 0.096 g/kg/h and 0.241 g/kg/h, respectively, for men. These figures widely deviate from gender-unspecific values commonly used in Germany (0.1 and 0.2 g/kg/h, respectively). The corresponding values for the BrAC were 0.061 mg/l/h and 0.124 mg/l/h for women and 0.049 mg/l/h and 0.112 mg/l/h for men. The probability of an over- or underestimation of the abovementioned extreme values is 0.3% in each case.

show abstract

“…Some authors negate these differences [11,13,[24][25][26][27][28][29]; however, the majority of the studies report a significantly higher elimination rate in women [4][5][6][7][8][9][10][11][12][13][14][15][16][17]23,30]. Admittedly, the possible causes discussed in the respective gender-related differences are quite varied.…”

Section: Discussionmentioning

confidence: 96%

The influence of sex hormones on the elimination kinetics of ethanol

Dettling

Skopp

Graw³

et al. 2008

Forensic Science International

View full text Add to dashboard Cite

Sex Differences in the Metabolism of Ethanol and Acetaldehyde in Normal Subjects

Cited by 69 publications

References 21 publications

Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project

Patterns of alcohol consumption in 10 European countries participating in the European Prospective Investigation into Cancer and Nutrition (EPIC) project

A regression model applied to gender-specific ethanol elimination rates from blood and breath measurements in non-alcoholics

The influence of sex hormones on the elimination kinetics of ethanol

Contact Info

Product

Resources

About