Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas

Li, Hong; Park, Henry S.; Osborn, Heather A.; Judson, Benjamin L.

doi:10.1186/s41199-018-0031-y

Cited by 23 publications

(21 citation statements)

References 29 publications

(29 reference statements)

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“…Similar findings of low HPV integration rates have been reported in OC patients when compared to OPC patients [49,51]. This is further supported by previous reports of no statistically significant differences in prognostic and survival outcomes between HPV-negative and -positive patients with non-OPC conditions, including OC [52][53][54]. Indeed, a recent study demonstrated that HPV is uncommonly associated with the oncogenesis of OC [55].…”

Section: Discussionsupporting

confidence: 87%

“…To investigate the HPV type distribution in patients with OPMD and OC, a high-throughput MALDI-TOF mass spectrometry-based method (Mass Array Platform, Agena Bioscience, Hamburg, Germany) was used, as previously described [18]. This method is able to detect 16 HPV DNA types (HPV16, 18,31,33,35,39,45,51,52,53,56,58,59, 66, 68 and 73) in a single well.…”

Section: Low and High-risk Hpv Dna Genotypingmentioning

confidence: 99%

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Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers

et al. 2020

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The role of human papillomavirus type 16 (HPV16) in oral potentially malignant disorders (OPMD) and oral cavity carcinoma (OC) is still under debate. We investigated HPV16 prevalence in unstimulated saliva, oral rinse samples, oral swabs and tumour biopsies collected from OPMD (n = 83) and OC (n = 106) patients. HPV16 genotype, viral load, physical status (episomal vs. integrated) and tumour p16INK4a expression were determined. Oral HPV16 prevalence was higher in OC than in OPMD, but this difference was not statistically significant (7.5% (8/106) versus 3.6% (3/83), odds ratio (OR): 2.18, 95% confidence interval (CI): 0.56, 8.48, p = 0.26). There was a significant association (p < 0.05) between oral HPV16 infection and heavy tobacco consumption. Real-time PCR results indicated that no integration events occurred in either OPMD or OC cases based on the HPV16 E2/E6 ratio. HPV16 positive OPMD and OC patients had similar HPV16 E2 and E6 viral loads. The inter-rater agreement between tumour p16INK4a expression and oral HPV16 infection was considered as fair (k = 0.361) for OC. Our data suggest that the involvement of HPV16 in oral carcinogenesis is limited.

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Section: Discussionsupporting

confidence: 87%

Section: Low and High-risk Hpv Dna Genotypingmentioning

confidence: 99%

Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers

et al. 2020

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“…A more recent population study on data retrieved from the National Cancer Database (NCDB) from 2010 to 2014, representing over 70% of patients in the USA, shows a higher HPV positivity in men than in women for both OPSCC (66% vs. 50%) and OCSCC (16% vs. 11%). 67 In a cohort of 21,627 OPSCC patients, the prevalence of HPV-driven tumours is 6.3-fold higher in men than in women, whereas considering the 9080 OCSCC patients the ratio is reduced to a 2.6-fold change (Table 1). A higher prevalence in men has also been observed for HPV-negative OPSCC or OCSCC patients, albeit to a lesser extent (Table 1).…”

Section: Stratification Of Hpv-related Hnscc By Sexmentioning

confidence: 99%

“…A higher prevalence in men has also been observed for HPV-negative OPSCC or OCSCC patients, albeit to a lesser extent (Table 1). 67 Within all four categories of patients (HPV-positive OPSCC and OCSCC, and HPV-negative OPSCC and OCSCC), women are older at the age of diagnosis, but have cancers that are diagnosed at earlier tumour (T) and node (N) stages, compared with men. 67 In HPVnegative OPSCC cases, Kaplan-Meier analysis shows a significantly higher overall survival (OS) in men than in women (Table 1), diverging from a previous report, 68 although in that study patients were not stratified by HPV.…”

Section: Stratification Of Hpv-related Hnscc By Sexmentioning

confidence: 99%

Human papillomavirus as a driver of head and neck cancers

2019

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The human papillomavirus (HPV) family includes more than 170 different types of virus that infect stratified epithelium. High-risk HPV is well established as the primary cause of cervical cancer, but in recent years, a clear role for this virus in other malignancies is also emerging. Indeed, HPV plays a pathogenic role in a subset of head and neck cancers-mostly cancers of the oropharynx-with distinct epidemiological, clinical and molecular characteristics compared with head and neck cancers not caused by HPV. This review summarises our current understanding of HPV in these cancers, specifically detailing HPV infection in head and neck cancers within different racial/ethnic subpopulations, and the differences in various aspects of these diseases between women and men. Finally, we provide an outlook for this disease, in terms of clinical management, and consider the issues of 'diagnostic biomarkers' and targeted therapies.

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“…The rate of HPV infection in oral cavity cancer was about 13.4% while the infection rate was 36.7% in oropharyngeal cancer in the United States. [20] The HPV infection rate in OSCC is lower than the oropharyngeal cancer. In female OSCC patients, the frequency of HPV infection (9.6%) was much lower than the male (15.8%).…”

Section: Discussionmentioning

confidence: 99%

Female Versus Male Oral Cavity Cancer: is There a Difference?

Lee¹,

Chien²,

Young³

et al. 2020

Preprint

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Objectives: Oral cavity squamous cell carcinoma (OSCC) is a leading cause of death in Taiwan, and most of the patients are male. Little is known about the differences in risk factors, cancer characteristics and treatment outcomes in female patients. The study aim is to investigate the clinicopathological and outcome differences between gender in patients affected by oral cancer in Taiwan.Methods: This is a retrospective study based on data obtained between 1995 and 2019. A total of 2,046 patients were recruited for analysis. Cancer characteristics, risk factors and treatment outcomes in patients with oral cancer between genders were collected. Results: Female patients represented the 6.7% of the entire cohort of study. Females were diagnosed at an older age and at an earlier local stage compared to male patients (p < 0.001). The female patients were less exposed to cigarette, alcohol, and betel-nut (BQ) (all p-values < 0.001). Tongue (55.1%) was the most frequent subsite involved in the female group, while buccal (38.4%) and tongue (35.3%) were more likely (p < 0.001) to be associated with male gender. In tongue cancer subgroup, female patients presented less frequently extra-nodal extension compared with male patients (p = 0.040). During the follow-up period, there was no significant difference in recurrence and overall deaths between genders.Conclusion:In Taiwan, the male to female ratio in OSCC is 14:1. The tumor subsite distribution, environment exposure and stage distribution are different between females and male. There are no differences in term of survival between female and male OSCC patients.

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Sex differences in patients with high risk HPV-associated and HPV negative oropharyngeal and oral cavity squamous cell carcinomas

Cited by 23 publications

References 29 publications

Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers

Oral HPV16 Prevalence in Oral Potentially Malignant Disorders and Oral Cavity Cancers

Human papillomavirus as a driver of head and neck cancers

Female Versus Male Oral Cavity Cancer: is There a Difference?

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