Sex differences in memory and intracellular signaling after methamphetamine binge treatment

Object recognition tasks in rats: Does sex matter?

“…Graphical flow diagram of the article selection process (n: number of articles in each phase). Fielding et al, 2012;Howland et al, 2012;Klug and van den Buuse, 2012;Mansouri et al, 2012;van Goethem et al, 2012;Zamberletti et al, 2012;Kolyaduke and Hughes, 2013;Marco et al, 2013;Hill et al, 2014;Abbott et al, 2016;Alteba et al, 2016;Anselmi et al, 2016;Barbie-Shoshani et al, 2016;Turgeon et al, 2016;Arfa-Fatollahkhani et al, 2017;Bengoetxea et al, 2017;Jordan and Andersen, 2018;Lian et al, 2018;Winther et al, 2018;Bruijnzeel et al, 2019;Klambatsen et al, 2019;Sadegzadeh et al, 2020), percentage of time-relative time exploring the novel object considering total amount of object exploration (Pereira et al, 2008;Bowman et al, 2009Bowman et al, , 2015van Goethem et al, 2012;Nelson et al, 2018;Ellis et al, 2020;Macht et al, 2020;Gillera et al, 2021;Peay et al, 2021), or absolute time-duration of novel object exploration (Paris and Frye, 2011;Reichel et al, 2012;Weston et al, 2014;Gonzales et al, 2015;Braun et al, 2018;Santollo et al, 2019;Villanueva Espino et al, 2020).…”

“…Indeed, many animals had been previously submitted to these manipulations, without including female rats that did not go through those procedures. In addition, most articles did not make it clear if they used these manipulations or how they evaluated the consequences of that use (Klambatsen et al, 2019;Santollo et al, 2019). Some of them used females submitted to VLP as controls and compared them to intact males and gonadectomized females (Cost et al, 2012).…”

“…In another experiment, the behavior of intact and ovariectomized females was similar, but it is not clear if intact females were submitted to estrous cycle monitoring. In another study, Klambatsen et al (2019) compared ovariectomized females and intact females in the NOR task; both the groups differentiated the objects and spent a larger percentage of time with the novel object, but it is not clear if intact females were submitted to estrous cycle monitoring (Klambatsen et al, 2019).…”

Sex differences in methamphetamine use disorder perused from pre-clinical and clinical studies: Potential therapeutic impacts

“…Where, Hirata et al (1996) had reported that acute injections of METH (2.5 and 5.0 mg/kg) showed greater decreases (48% and 73%, respectively) in striatal DA transporters in male compared to female mice (25% and 63%, respectively). Interestingly, Klambatsen et al (2019) reported that injection of METH (4 ×5 mg/kg) caused no decreases in DAT protein levels in adult male Sprague-Dawley rats but small decreases in female rats. More recently, Sepulveda et al (2021) reported that escalating METH doses given over a period of three weeks resulted in significant decreases in serotonin 1 A receptor (5-HT1A) receptor binding in the dorsal raphe nucleus of only male mice.…”

“… Jacobskind et al (2018) administered repeated injections of METH (5 mg/kg) once daily for 10 days and reported that male, but not female, mice showed decreased levels of c-Fos in the bed nucleus of the stria terminalis (BNST). Klambatsen et al (2019) reported that injections of rats with a binge METH regimen (4 ×4 mg/kg, every 2 h) caused significant increases in FosB protein levels in both dorsal and ventral striatum only in males but not in females.…”