Sex-Independent Cognition Improvement in Response to Kaempferol in the Model of Sporadic Alzheimer’s Disease

Babaei, Parvin; Eyvani, Kimia; Kouhestani, Somayeh

doi:10.1007/s11064-021-03289-y

Cited by 24 publications

(14 citation statements)

References 49 publications

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“…In this context, some studies aimed to target neuroinflammation et al, 2019). It was also reported that KMP promotes spatial learning and memory via decreasing TNFα and antioxidative enzymes independent of sex difference (Babaei et al, 2021;Kouhestani et al, 2018).…”

Section: K Mp a S An Anti -Neuroinfl Ammatory Ag Ent In Admentioning

confidence: 98%

“…Finally, they suggested that KMP could have neuroprotective impacts possibly via protecting BBB integrity, and down‐regulating the HMGB1/TLR4 pathway (Yang et al, 2019). It was also reported that KMP promotes spatial learning and memory via decreasing TNF‐ α and antioxidative enzymes independent of sex difference (Babaei et al, 2021; Kouhestani et al, 2018).…”

Section: Kmp As An Anti‐neuroinflammatory Agent In Admentioning

confidence: 99%

“…Their study demonstrated that KMP could be a possible neuroprotective factor opposing cognitive impairment in AD (Kouhestani et al, 2018). The same group (Babaei et al, 2021) has recently published an interesting study aiming to assess the role of sex difference following receiving KMP on a rat model of sporadic AD. They reported that KMP has similar antioxidative, anti‐inflammatory, and neuroprotective effects in both genders (Babaei et al, 2021).…”

Section: Kmp Attenuates Oxidative Stress In Admentioning

confidence: 99%

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Kaempferol as a potential neuroprotector in Alzheimer's disease

Nejabati

Roshangar

2022

Journal of Food Biochemistry

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Alzheimer's disease (AD), the most prevalent neurodegenerative disorder, is largely associated with cognitive disability, amnesia, and abnormal behavior, which accounts for about two third of people with dementia worldwide. A growing body of research demonstrates that AD is connected to several factors, such as aberrant accumulation of amyloid‐beta (Aβ), increase in the hyperphosphorylation of Tau protein, and the formation of neurofibrillary tangles, mitochondrial dysfunction, and inordinate production of reactive oxygen species (ROS). Despite remarkable efforts to realize the etiology and pathophysiology of AD, until now, scientists have not developed and introduced medications that can permanently cease the progression of AD. Thus, nowadays, research on the role of natural products in the treatment and prevention of AD has attracted great attention. Kaempferol (KMP), one of the prominent members of flavonols, exerts its ameliorative actions via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. Therefore, in this review article, we outlined the possible effects of KMP in the prevention and treatment of AD. Practical applications Kaempferol (KMP) exerts its ameliorative actions against AD via attenuating oxidative stress and inflammation, reducing Aβ‐induced neurotoxicity, and regulating the cholinergic system. The beneficial effects of KMP were addressed in both in vitro and in vivo studies; however, conducting further research can warrant its long‐term effects as a safe agent. Therefore, after confirming its favorable functions in the prevention and treatment of AD, it could be used as a safe and effective agent.

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Section: K Mp a S An Anti -Neuroinfl Ammatory Ag Ent In Admentioning

confidence: 98%

Section: Kmp As An Anti‐neuroinflammatory Agent In Admentioning

confidence: 99%

Section: Kmp Attenuates Oxidative Stress In Admentioning

confidence: 99%

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Kaempferol as a potential neuroprotector in Alzheimer's disease

Nejabati

Roshangar

2022

Journal of Food Biochemistry

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“…In addition, STAT3 deletion in the APP/PS1 mice model was related to smaller Aβ plaques, increased Aβ clearance and reduced pro-inflammatory cytokine release [ 139 ]. In an AD model induced by intracerebroventricular streptozotocin delivery in Wistar rats, it has been shown that kaempferol reduced cognitive impairment, specifically through antioxidative mechanisms such as an increase in the levels of superoxide dismutase (SOD) and GSH [ 140 ]. Although it was not tested in a specific AD model, kaempferol reduced the activation of complement C3 and the neurotoxic astrocyte profile induced by 3-nitropropionic acid in rats [ 141 ].…”

Section: Astrocytes As a Therapeutic Target: Treatment And Neuroprote...mentioning

confidence: 99%

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments

Rodríguez-Giraldo

González-Reyes

Ramírez-Guerrero

et al. 2022

IJMS

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Alzheimer’s disease (AD) is a frequent and disabling neurodegenerative disorder, in which astrocytes participate in several pathophysiological processes including neuroinflammation, excitotoxicity, oxidative stress and lipid metabolism (along with a critical role in apolipoprotein E function). Current evidence shows that astrocytes have both neuroprotective and neurotoxic effects depending on the disease stage and microenvironmental factors. Furthermore, astrocytes appear to be affected by the presence of amyloid-beta (Aβ), with alterations in calcium levels, gliotransmission and proinflammatory activity via RAGE-NF-κB pathway. In addition, astrocytes play an important role in the metabolism of tau and clearance of Aβ through the glymphatic system. In this review, we will discuss novel pharmacological and non-pharmacological treatments focused on astrocytes as therapeutic targets for AD. These interventions include effects on anti-inflammatory/antioxidant systems, glutamate activity, lipid metabolism, neurovascular coupling and glymphatic system, calcium dysregulation, and in the release of peptides which affects glial and neuronal function. According to the AD stage, these therapies may be of benefit in either preventing or delaying the progression of the disease.

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“…improved the spatial learning and memory impairment in SZT-injected (i.c.v.) rats (both male and ovariectomized female) by the mechanisms of antioxidation and antineuroinflammation. , Besides, Aβ-induced damages was also ameliorated by kaempferol as evidenced by the improved cognitive and memory function in Aβ 1–40 -injected (i.c.v.) mice and suppressed apoptosis in Aβ 25–35 -damaged PC12 cells after kaempferol treatment. − Mechanisms for those effects involved the activation of the cytoprotective BDNF/TrkB/CREB pathway, enhancement of the antiapoptotic Erβ/ERK1/2 pathway, and inhibition of oxidative stress. − Moreover, a study conducted with the transgenic Drosophila (expressing human Aβ42) model found that kaempferol delayed memory loss, reduced oxidative stress, and inhibited AChE activity .…”

Section: Neuroprotective Flavonoids In Mung Beanmentioning

confidence: 99%

Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer’s Disease: A Review

Zhou

Liu

et al. 2021

J. Agric. Food Chem.

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Mung bean contains various neuroprotective polyphenols, so it might be a healthy food for Alzheimer’s disease (AD) prevention. Totally, 19 major phenolic compounds were quantified in mung bean, including 10 phenolic acids and 9 flavonoids. After summarizing their contents and effective doses in rodent AD models, it was speculated that vitexin, isovitexin, sinapic acid, and ferulic acid might be the major bioactive compounds for mung bean-mediated neuroprotection. The mechanisms involved inhibition of β-amyloidogenesis, tau hyperphosphorylation, oxidative stress, and neuroinflammation, and promotion of autophagy and acetylcholinesterase enzyme activity. Notably, the neuroprotective phenolic profile in mung bean changed after germination, with decreased vitexin and isovitexin, and increased rutin, isoquercitrin, isorhamnetin, and caffeic acid detected. However, only studies of individual phenolic compounds in mung bean are published at present. Hence, further studies are needed to elucidate the neuroprotective activities and mechanisms of extractions of mung bean seeds and sprouts, and the synergism between different phenolic compounds.

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Sex-Independent Cognition Improvement in Response to Kaempferol in the Model of Sporadic Alzheimer’s Disease

Cited by 24 publications

References 49 publications

Kaempferol as a potential neuroprotector in Alzheimer's disease

Kaempferol as a potential neuroprotector in Alzheimer's disease

Astrocytes as a Therapeutic Target in Alzheimer’s Disease–Comprehensive Review and Recent Developments

Neuroprotective Potential of Mung Bean (Vigna radiata L.) Polyphenols in Alzheimer’s Disease: A Review

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