Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activity

Ding, Changhai; Cicuttini, Flavia Maria; Scott, F; Glisson, Michael; Jones, Graeme

doi:10.1093/rheumatology/keg374

Cited by 96 publications

(81 citation statements)

References 18 publications

(37 reference statements)

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“…A vast majority of earlier studies on sex differences in knee cartilage have focused on cartilage thickness and volume and have reported lower cartilage volume and thickness in women compared with men in healthy young and older individuals without knee OA [11,16,18,19,41]. However, it is not known if thicker cartilage by itself is protective against knee OA [17].…”

Section: Discussionmentioning

confidence: 99%

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Kumar

Souza

MacLeod

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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Background Women are at a greater risk for knee osteoarthritis (OA), but reasons for this greater risk in women are not well understood. It may be possible that differences in cartilage composition and walking mechanics are related to greater OA risk in women.Questions/purposes (1) Do women have higher knee cartilage and meniscus T 1q than men in young healthy, middle-aged non-OA and OA populations? (2) Do women exhibit greater static and dynamic (during walking) knee loading than men in young healthy, middle-aged non-OA and OA populations? Methods Data were collected from three cohorts: (1) young active (\ 35 years) (20 men, 13 women); (2) middleaged (C 35 years) without OA (Kellgren-Lawrence [KL] grade \ 2) (43 men, 65 women); and (3) middle-aged with OA (KL [ 1) (18 men, 25 women). T 1q and T 2 relaxation times for cartilage in the medial knee, lateral knee, and patellofemoral compartments and medial and lateral menisci were quantified with 3.0-T MRI. A subset of the participants underwent three-dimensional motion capture during walking for calculation of peak knee flexion and adduction moments, flexion and adduction impulses, and peak adduction angle. Differences in MR, radiograph, and gait parameters between men and women were compared in the three groups separately using multivariate analysis of variance. Conclusions These data demonstrate differences in cartilage composition and gait mechanics between men and women in young healthy, middle-aged healthy, and OA cohorts. Considering the cross-sectional nature of the study, longitudinal research is needed to investigate if these differences in cartilage composition and walking mechanics are associated with a greater risk of lateral tibiofemoral or patellofemoral OA in women. Future studies should also investigate the relative risk of lateral versus medial patellofemoral cartilage degeneration risk in women compared with men. Level of Evidence Level III, retrospective study.

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Section: Discussionmentioning

confidence: 99%

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Kumar

Souza

MacLeod

et al. 2015

Clinical Orthopaedics &Amp; Related Research

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show abstract

“…Sexand age-related differences in OA are well described and considered to be a key aspect of development and discovery of new treatments. Sex differences in knee geometry (47,48) and biomechanical properties (49) are well known, but it is not known if these differences contribute to the disparity in the prevalence of OA between men and women. Researchers have attempted to identify differences at the cellular level between OA in men and OA in women.…”

Section: Discussionmentioning

confidence: 99%

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Matsumoto¹,

Kubo²,

Meszaros³

et al. 2008

Arthritis & Rheumatism

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“…Pudemos observar, em nosso estudo, uma maior participação de mulheres acima de 60 anos. Segundo Ding 19 , as mulheres realizam mais consultas médicas e entre as principais queixas encontram-se as doenças crônico-degenerativas, como a OA. Outro fator de prevalência bastante relatado em outros estudos 20 , e também comprovado no nosso, é o elevado IMC nos pacientes com OA de joelho, sendo um dos principais responsáveis pela dor.…”

Section: Discussionunclassified

Efeito do ultrassom pulsado e do ultrassom contínuo associado a exercícios em pacientes com osteoartrite de joelho: estudo piloto

2012

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RESUMO | A osteoartrite (OA) é uma doença crônica associada à morbidade significante. O objetivo deste estudo foi comparar o exercício isolado ao ultrassom pulsado (USP) e contínuo (USC) associados a exercício na redução da dor, melhora da amplitude de movimento (ADM), força muscular (FM), qualidade de vida (QV) e funcionalidade de pacientes com OA de joelhos. Trinta indivíduos, 50 a 75 anos, OA grau 2-4, foram randomizados: Grupo USC (USC + exercícios), Grupo USP (USP + exercícios) e Grupo EXE (exercícios). Os grupos foram avaliados antes e após o tratamento. A intervenção foi realizada três vezes por semana durante oito semanas: nas quatro primeiras foi aplicado USC ou USP e, nas demais foram realizados os exercícios. O Grupo EXE realizou exercícios durante oito semanas. Para análises intragrupos, utilizou-se o teste de Wilcoxon e, intergrupos, o teste de Kruskall-Walis. Na comparação intragrupos, o Grupo USC apresentou melhora significativa (p≤0,05) nas variáveis da Western Ontario and McMaster Universities Osteoarthritis (WOMAC) dor, função e escore total; o Grupo USP na dor repouso, ADM, FM e nas variáveis da WOMAC dor, função e escore total; já, o Grupo EXE na mobilidade e ADM. Na comparação intergrupos, o Grupo USC apresentou melhora significativa (p≤0,05) quando comparado aos demais grupos na dor repouso, ADM, escores função e total da WOMAC e o Grupo EXE na dor da WOMAC. A associação do USC a exercícios foi mais efetiva na melhora da dor, ADM, função e QV em pacientes com OA de joelho.Descritores | osteoartrite do joelho; terapia por exercício; terapia por ultrassom.ABSTRACT | Osteoarthritis (OA) is a chronic disease associated with significant morbidity. The aim of this study was to compare the isolated exercises with association of pulsed (PUS) and continuous (CUS) ultrasound with exercise in reducing pain, improving range of motion (ROM), muscle strength (MS), quality of life (QL) and functionality of patients with knee OA. Thirty individuals, 50 to 75 years old, 2-4 OA grade, were randomized: Group CUS (CUS + exercise), Group PUS (PUS + exercise) and EXE group (exercises). The groups were evaluated before and after treatment. The intervention was performed three times a week for eight weeks: in the first four weeks, it was applied CUS or PUS, and in other weeks, exercises were carried out. The EXE group performed exercises for eight weeks. For intra-group analysis, the Wilcoxon test was used and intergroup analysis, the Kruskall-Walis test was used. Within the groups, the USC group showed significant improvement (p≤0.05) in variables of Western Ontario and McMaster Universities Osteoarthritis (WOMAC) pain, function and total score; the Group USP in pain-rest, ROM, MS, variables of WOMAC pain, function and total score; and EXE Group in mobility and ROM. In intergroup comparison, the USC group showed significant improvement (p≤0.05) when compared to other groups in pain-rest, ROM, variables of WOMAC function and total score and EXE group in WOMAC-pain. The association of USC and exercise was more effe...

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Sex differences in knee cartilage volume in adults: role of body and bone size, age and physical activity

Cited by 96 publications

References 18 publications

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

Are There Sex Differences in Knee Cartilage Composition and Walking Mechanics in Healthy and Osteoarthritis Populations?

The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Efeito do ultrassom pulsado e do ultrassom contínuo associado a exercícios em pacientes com osteoartrite de joelho: estudo piloto

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