The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Matsumoto, Tomoyuki; Kubo, Seiji; Meszaros, Laura Beth; Corsi, Karin A.; Cooper, Gregory M.; Li, Guangheng; Ūsas, Arvydas; Osawa, Aki; Fu, Freddie H.; Huard, Johnny

doi:10.1002/art.24125

Cited by 81 publications

(80 citation statements)

References 51 publications

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“…[8][9][10] MDSCs are known to exhibit sex differences in muscle regeneration, as well as chondrogenic and osteogenic differentiation both in vivo and in vitro. [11][12][13] MDSCs isolated from female mice have a higher regeneration efficiency when transplanted into mdx or mdx/SCID mice, a dystrophindeficient animal model of muscular dystrophy. In mdx mice, a significant effect of host sex was also seen, with female hosts exhibiting higher regeneration.…”

mentioning

confidence: 99%

Effect of Host Sex and Sex Hormones on Muscle-Derived Stem Cell-Mediated Bone Formation and Defect Healing

Meszaros

Ūsas

Cooper

et al. 2012

Tissue Engineering Part A

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Muscle-derived stem cells (MDSCs) are known to exhibit sexual dimorphism, by donor sex, of osteogenic, chondrogenic, and myogenic differentiation potential in vitro. Moreover, host sex differences in the myogenic capacity of MDSCs in vivo are also observed. This study investigated the role of host sex and host sex hormones in MDSC-mediated bone formation and healing. Using unaltered male, castrated male, unaltered female, and ovariectomized female mice, both MDSC-mediated ectopic bone formation and cranial defect healing were examined. Male hosts, whether unaltered or castrated, form significantly larger volumes of MDSC-mediated ectopic bone than female hosts (either unaltered or ovariectomized), and no differences in ectopic bone volume were found between hosts of the same sex. In a cranial defect healing model, similar results were foundunaltered and castrated male hosts display larger volumes of bone formed when compared with unaltered and ovariectomized female hosts. However, in this healing model, some volume differences were found between hosts of the same sex. In both models, these differences were attributed to varying rates of endochondral bone formation in male and female hosts.

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confidence: 99%

Effect of Host Sex and Sex Hormones on Muscle-Derived Stem Cell-Mediated Bone Formation and Defect Healing

Meszaros

Ūsas

Cooper

et al. 2012

Tissue Engineering Part A

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“…In vivo, at 4, 12, and 24 weeks post-operative, the muscle derived MSC and chondrocyte groups were similar and superior to the gel control group. Following this study, the same group also demonstrated that sex influences chondrogenic differentiation and cartilage regeneration potential, with male muscle derived MSCs superior over female [68]. To understand muscle derived MSCs further, Li et al [69], isolated both fascia derived cells from the gluteus maximus muscle fascia and muscle derived cells from the muscle body of rats.…”

Section: Musclementioning

confidence: 85%

Chondrogenic Progenitor Cells and Articular Cartilage Repair

Chu

Friel²

2012

Rheumatology

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Treatment of articular cartilage injury is challenging due in part to the paucity of potential repair cells within articular cartilage. While chondrocytes can be expanded in culture and returned to the site of injury, autologous applications require removal of healthy articular cartilage -a limited resource. Additional sources of chondrogenic progenitor cells that may be suitable for articular cartilage repair include Mesenchymal Stem Cells (MSCs) isolated from more abundant tissues such as bone marrow, synovium, infrapatellar fat pad, subcutaneous fat, periosteum, perichondrium, and muscle.

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“…Muscle-derived MSC has been investigated as a cell source [74], and potentials of other sources such as placenta [75], amnion [76], umbilical cord blood [77], and ear elastic cartilage [78] have been tested in previous in vitro and animal studies.…”

Section: Other Cell Sourcesmentioning

confidence: 99%

Cartilage repair techniques in the knee: stem cell therapies

Yoshiya

Dhawan

2015

Curr Rev Musculoskelet Med

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Among the surgical options for large full-thickness chondral injuries, cell-based therapy has been practiced and its satisfactory outcomes have been reported. One area that appears promising is cell-based therapies utilizing stem cells. Various tissues within the human body contain mesenchymal stem cells (MSCs) from where these can be harvested. These include bone marrow, adipose, synovium, peripheral blood, and umbilical cord. In this article, both preclinical animal studies and clinical studies dealing with the use of MSCs for cartilage repair of the knee are reviewed. Majority of the clinical papers have shown promising results; however, there are a limited number of studies of high evidence level. Clinical significance of the stem cell therapy as compared to other surgical options as well as optimization of the procedure in terms of cell type and delivery method is still to be determined.

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The influence of sex on the chondrogenic potential of muscle‐derived stem cells: Implications for cartilage regeneration and repair

Abstract: Conclusion. Our findings demonstrate that sex influences the chondrogenic differentiation and articular cartilage regeneration potential of MDSCs. Compared with female MDSCs, male MDSCs display more chondrogenic differentiation and better cartilage regeneration potential.

Cited by 81 publications

References 51 publications

Effect of Host Sex and Sex Hormones on Muscle-Derived Stem Cell-Mediated Bone Formation and Defect Healing

Effect of Host Sex and Sex Hormones on Muscle-Derived Stem Cell-Mediated Bone Formation and Defect Healing

Chondrogenic Progenitor Cells and Articular Cartilage Repair

Cartilage repair techniques in the knee: stem cell therapies

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