Sex differences in estrogen and androgen receptors in hamster brain

Chen, Tong J.; Tu, Wen Wen

doi:10.1016/0024-3205(92)90450-4

Cited by 29 publications

(14 citation statements)

References 40 publications

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“…Sex differences in gonadectomized male and female rats. In every brain region androgen receptors have been reported in micropunched tissue sampled androgen receptor levels were higher in males than in from intact males and females (3,30 ), and male and female rats females. Androgen receptor levels were significantly higher in the receiving exogenous testosterone ( 2).…”

Section: Inclusion Of Varying Amounts Of Non-androgen Concentratingmentioning

confidence: 96%

“…nique of androgen receptor binding has been employed, but most Protein values for micropunches taken from brain nuclei of of these studies were done on males and females exposed to males and females are shown in Table 2. The protein content was differing amounts of androgens and estrogens (2,3,30) which measured to determine if dissimilarities in the amount of tissue again makes interpretation problematic. In the only study which sampled could account for the sex differences.…”

Section: Inclusion Of Varying Amounts Of Non-androgen Concentratingmentioning

confidence: 99%

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Sex Differences in Cytosolic Androgen Receptors in Gonadectomized Male and Female Rats

McGinnis

Katz

1996

J Neuroendocrinology

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The purpose of this experiment was to determine if there are sex differences in cytosolic androgen receptors (AR) in individual brain nuclei. Bilateral 500 mu diameter samples from 300 mu thick frozen brain sections were micropunched from males and females 2-3 weeks following gonadectomy. Tissue samples were taken from 12 brain nuclei: lateral septum, bed nucleus of the stria terminalis, medial preoptic nucleus, anterior hypothalamic area, arcuate nucleus, corticomedial nucleus of the amygdala, lateral preoptic area, parietal cortex, medial nucleus of the amygdala, dorsomedial nucleus of the hypothalamus, ventromedial nucleus of the hypothalamus, and dorsal hippocampus. Cytosolic ARs were found in brain regions involved in the neuromodulation of androgen dependent responses. These data suggest that behavioral differences in male reproductive responses may be the sexually dimorphic distribution of androgen receptor containing neurons.

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Section: Inclusion Of Varying Amounts Of Non-androgen Concentratingmentioning

confidence: 96%

Section: Inclusion Of Varying Amounts Of Non-androgen Concentratingmentioning

confidence: 99%

Sex Differences in Cytosolic Androgen Receptors in Gonadectomized Male and Female Rats

McGinnis

Katz

1996

J Neuroendocrinology

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“…In the rat, hamster, and other rodents, androgen-and estrogen-receptors are distributed primarily in the cMePD and BNSTpm. [20][21][22][23][24] In the adult rat these cell groups are sexually dimorphic with respect to nuclear volume, 25,26 synaptic organization, 27,28 and neurotransmitters. 13,14,[29][30][31] Furthermore, at least some of these sexually differentiated characteristics can be modulated by hormones in adulthood.…”

Section: Gonadal-steroid Receptors and Sexual Dimorphism In The Mediamentioning

confidence: 99%

The Medial Extended Amygdala in Male Reproductive Behavior A Node in the Mammalian Social Behavior Network

Newman

1999

Annals of the New York Academy of Sciences

1,032

923

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Hormonal and chemosensory signals regulate social behaviors in a wide variety of mammals. In the male Syrian hamster, these signals are integrated in nuclei of the medial extended amygdala, where olfactory and vomeronasal system transmission is modulated by populations of androgen- and estrogen-sensitive neurons. Evidence from behavioral changes following lesions and from immediate early gene expression supports the hypothesis that the medial extended amygdala and medial preoptic area belong to a circuit that functions selectively in male sexual behavior. However, accumulated behavioral, neuroanatomical, and neuroendocrine data in hamsters, other rodents, and other mammals indicate that this circuit is embedded in a larger integrated network that controls not only male mating behavior, but female sexual behavior, parental behavior, and various forms of aggression. In this context, perhaps an individual animal's social responses can be more easily understood as a repertoire of closely interrelated, hormone-regulated behaviors, shaped by development and experience and modulated acutely by the environmental signals and the hormonal milieu of the brain.

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“…The spectrometry was calibrated with different concentrations of doxorubicin dissolved in DMSO. The cRGD peptide conjugated on the nanoparticle surface was calculated with the established fluorescamine method (21). The micro-structure of the NPs was visualized by transmission electron microscopy (TEM) (CM10, Microscope Philips) with 2% phosphotungstic acid staining.…”

Section: Characterization Of Nanoparticlesmentioning

confidence: 99%

Design of a Multifunctional PLGA Nanoparticulate Drug Delivery System: Evaluation of its Physicochemical Properties and Anticancer Activity to Malignant Cancer Cells

Wang

Chui

2009

Pharm Res

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Sex differences in estrogen and androgen receptors in hamster brain

Cited by 29 publications

References 40 publications

Sex Differences in Cytosolic Androgen Receptors in Gonadectomized Male and Female Rats

Sex Differences in Cytosolic Androgen Receptors in Gonadectomized Male and Female Rats

The Medial Extended Amygdala in Male Reproductive Behavior A Node in the Mammalian Social Behavior Network

Design of a Multifunctional PLGA Nanoparticulate Drug Delivery System: Evaluation of its Physicochemical Properties and Anticancer Activity to Malignant Cancer Cells

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