Sex differences in bronchiectasis patient characteristics: an analysis of the EMBARC cohort

Finch, Simon; Polverino, Eva; Blasi, Francesco; Ringshausen, FC; Soyza, Anthony De; Vendrell, Montserrat; Goeminne, Pieter; Boersma, Wim; Haworth, Charles; Murris-Espin, M.; Dimakou, Aikaterini; Loebinger, Michael R.; Menéndez, Rosário; Torres, A.; Welte, Tobias; Hill, Adam T.; Wilson, Robert; Elborn, Stuart; Aliberti, Stefano; Chalmers, James D.

doi:10.1183/13993003.congress-2018.pa2282

Cited by 3 publications

(4 citation statements)

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“…An analysis of the European Bronchiectasis Registry that included 11 204 patients, but which has not yet been peer reviewed found that males had more co-morbidities, were more likely have co-existing COPD, worse FEV 1 and had a higher severity of disease using the bronchiectasis severity index [141,142]. Consistent with other airway diseases, however, quality of life was worse in females [141,143]. The reasons for this require further study.…”

Section: Bronchiectasis and Cystic Fibrosis (Cf)mentioning

confidence: 99%

“…Differences in severity and outcome have been reported in non-CF bronchiectasis as well [141]. An analysis of the European Bronchiectasis Registry that included 11 204 patients, but which has not yet been peer reviewed found that males had more co-morbidities, were more likely have co-existing COPD, worse FEV 1 and had a higher severity of disease using the bronchiectasis severity index [141,142]. Consistent with other airway diseases, however, quality of life was worse in females [141,143].…”

Section: Bronchiectasis and Cystic Fibrosis (Cf)mentioning

confidence: 99%

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Just breathe: a review of sex and gender in chronic lung disease

Somayaji

Chalmers

2022

Eur Respir Rev

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Chronic lung diseases are the third leading cause of death worldwide and are increasing in prevalence over time. Although much of our traditional understanding of health and disease is derived from study of the male of the species – be it animal or human – there is increasing evidence that sex and gender contribute to differences in disease risk, prevalence, presentation, severity, treatment approach, response and outcomes. Chronic obstructive pulmonary disease, asthma and bronchiectasis represent the most prevalent and studied chronic lung diseases and have key sex- and gender-based differences which are critical to consider and incorporate into clinical and research approaches. Mechanistic differences present opportunities for therapeutic development whereas behavioural and clinical differences on the part of patients and providers present opportunities for greater education and understanding at multiple levels. In this review, we seek to summarise the sex- and gender-based differences in key chronic lung diseases and outline the clinical and research implications for stakeholders.

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Section: Bronchiectasis and Cystic Fibrosis (Cf)mentioning

confidence: 99%

Section: Bronchiectasis and Cystic Fibrosis (Cf)mentioning

confidence: 99%

Just breathe: a review of sex and gender in chronic lung disease

Somayaji

Chalmers

2022

Eur Respir Rev

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“…Patients interviewed for this study had similar characteristics to adult patients enrolled in bronchiectasis registries around the world, suggesting that this instrument could be deployed globally. In the US Bronchiectasis Research Registry (BRR), the European Multicentre Bronchiectasis Audit and Research Collaboration (EMBARC), and the Australian Bronchiectasis Registry (ABR), patients with bronchiectasis were predominantly female and white, and the most common comorbidities were asthma and [3,[18][19][20]. A UK population-based study showed similar findings [21].…”

Section: Discussionmentioning

confidence: 94%

The Bronchiectasis Exacerbation Diary: a novel patient-reported outcome for non-cystic fibrosis bronchiectasis

et al. 2023

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Bronchiectasis is a chronic, progressive lung disease believed to result from a vicious cycle of infection and inflammation, with symptoms of chronic cough with sputum production, chronic fatigue, rhinosinusitis, chest pain, breathlessness, and haemoptysis. There are currently no established instruments to monitor daily symptoms and exacerbations for use in clinical trials. Following a literature review and three expert clinician interviews, we conducted concept elicitation interviews with 20 patients with bronchiectasis to understand their personal disease experience. Findings from literature and clinician feedback were used to develop a draft version of the Bronchiectasis Exacerbation Diary (BED), which was designed to monitor key symptoms on a daily basis and during exacerbations. Patients were eligible to be interviewed if they were US residents aged ≥18 years, had a computed tomography scan–confirmed diagnosis of bronchiectasis with ≥2 exacerbations in the previous two years, and had no other uncontrolled respiratory conditions. Four waves of five patient interviews each were conducted. Patients (N=20) had a mean (standard deviation) age of 53.9 (12.8) years, and most were female (85%) and white (85%). Thirty-three symptoms and 23 impacts arose from the patient concept elicitation interviews. The BED was revised and finalised based upon patient feedback. The final BED is a novel, eight-item patient-reported outcome (PRO) instrument for monitoring key exacerbation symptoms on a daily basis with content validity established through comprehensive qualitative research and direct patient insight. The BED PRO development framework will be completed following psychometric evaluations of the data from a phase 3 bronchiectasis clinical trial.

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“…This is the largest reported study of patients with bronchiectasis and haematological malignancy, and although retrospective, the data provide insight into the development of bronchiectasis in these patients. Our cohort had a male predominance, whereas non-CF bronchiectasis usually has a female predominance [7], probably reflecting that myeloid and lymphoid malignancies are more common in males [8]. Bronchiectasis in this cohort seemed to develop due to different mechanisms, either acquired IgG deficiency (mainly in patients with CLL or NHL) or allograft HSCT (47% of whom had pGVHD compared to <10% in all allograft HSCT patients) [9], but with some rarer causes.…”

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confidence: 99%

De novo bronchiectasis in haematological malignancies: patient characteristics, risk factors and survival

2019

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Patients with haematological malignancies often develop secondary immunodeficiency and respiratory infections that could predispose towards bronchiectasis, and this is supported by case reports and a previous small case series of 22 patients [1–4]. To improve understanding of this association we performed a retrospective review of patients with clinically significant bronchiectasis (defined as radiological evidence of bronchiectasis plus chronic productive cough or recurrent respiratory tract infections requiring antibiotic therapy) and haematological malignancy attending our respiratory clinic at a UK teaching hospital between January 2014 and April 2018. Patients were investigated according to the British Thoracic Society guideline [5].

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Sex differences in bronchiectasis patient characteristics: an analysis of the EMBARC cohort

Cited by 3 publications

References 0 publications

Just breathe: a review of sex and gender in chronic lung disease

Just breathe: a review of sex and gender in chronic lung disease

The Bronchiectasis Exacerbation Diary: a novel patient-reported outcome for non-cystic fibrosis bronchiectasis

De novo bronchiectasis in haematological malignancies: patient characteristics, risk factors and survival

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