Sex differences betweenHelicobacter pyloriinfection and cholesterol levels in an adult health checkup program

Abstract

BackgroundHelicobacter pylori (H pylori) infection is suggested to be a risk factor of metabolic syndrome (MS) and lipid abnormalities. The aim of this study was to investigate the influence of H pylori infection on MS and lipid abnormalities according to sex differences.Materials and MethodsWe analyzed a total of 4551 adults who received health checkups from January 2016 to May 2017. We enrolled participants who did not have a history of hypertension, diabetes, hyperlipidemia, or cancer among those who underwent endoscopy with a rapid urease test.ResultsWe included a total of 1065 participants, and 663 patients (62.3%) were H pylori‐positive. The H pylori infection rate was 59.3% (426/719) in males and 68.5% (237/346) in females. The mean level of total cholesterol (P = .003), low‐density lipoprotein (LDL) cholesterol (P = .046), and triglycerides (P = .029) were statistically higher in H pylori‐infected males. The mean level of high‐density lipoprotein (HDL) cholesterol was statistically lower in H pylori‐infected females (P = .032). Multivariate analysis showed that total cholesterol in males (odds ratio [OR], 1.007; 95% confidence interval [CI], 1.002‐1.011) and HDL cholesterol in females (OR, 0.983; 95% CI, 0.968‐0.998) were associated with active H pylori infection. The prevalence of MS was higher in both male and female H pylori‐infected groups; however, there was no statistical significance.ConclusionsH pylori infection is significantly related to increased total cholesterol in males and to decreased HDL cholesterol in females, which suggests that H pylori could affect lipid profiles and may be different by sex.

The association of Helicobacter Pylori infection with dyslipidaemia and other atherogenic factors in dyspeptic patients at St. Paul's Hospital Millennium Medical College

“…In the current study, H. pylori-infected patients had higher mean lipid profiles for TC, TG, and LDL-c. Similarly, previous studies indicated that H. pylori seropositive subjects had higher serum triglyceride, total cholesterol, and LDL-c concentrations when compared to healthy subjects [59,60,61,62,63,64]. Our findings were also in agreement with another Korean study which showed that H. pylorus was independently associated with an increased level of TC, and LDL-C [65].…”

Helicobacter pylori-Related Metabolic Parameters and Premalignant Gastric Mucosa Histological Lesions in Swiss Bariatric Patients

“…This observation is in line with previous bariatric studies reporting a predominance of women undergoing bariatric surgery [ 75 , 76 ]. Additionally, Hp -I is known in the literature to affect more women than men [ 77 , 78 ], although studies reporting a male predominance ought to be equally acknowledged [ 79 ]. Furthermore, estradiol-treated gerbils exhibited more intense and extended acute and follicular gastritis, compared to the control group [ 80 ].…”

“…Some possible insights include the following: females appear to exhibit a higher Hp burden than males [ 83 ]. Likewise, Hp (+) females display significantly decreased HDL cholesterol concentrations than males, whereas total cholesterol, LDL cholesterol, and triglycerides are statistically higher in Hp (+) males, thereby signifying that Hp might affect lipid profiles and may be different by gender [ 78 ]. Moreover, the mentioned T2DM, a component of MetS, and Hp -I have synergistic effects on gastric oncogenesis [ 69 ].…”

Changes in Metabolic Parameters by Helicobacter pylori Eradication According to Sex Differences

“…8 Although the effect of H. pylori eradication on MS and dyslipidemia has not been investigated, a retrospective study from Korea reported that H. pylori infection is associated with increased total cholesterol in males and decreased HDL cholesterol in females. 9 A recent Korean retrospective cohort study demonstrated that successful H. pylori eradication reduced the risk of developing low HDL cholesterol in females and high LDL cholesterol in males. 10 The baseline BMI differed between H. pylori-persistent and H. pylori-eradicated groups, but sex-specific subgroup analysis for BMI was not performed.…”