Sex difference in IgE sensitization associated with alcohol consumption in the general population

Roh, Daeyoung; Lee, Dong-Hee; Lee, Sang‐Kyu; Kim, Soo Whan; Kim, Sung Won; Cho, Jin Hee; Kim, Byung-Guk; Shin, Ji-Hyeon

doi:10.1038/s41598-019-48305-y

Cited by 7 publications

(10 citation statements)

References 56 publications

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“…Peripheral blood samples were collected after fasting for more than eight hours, and then were immediately processed and transported to a central laboratory (Neodin Medical Institute, Seoul, South Korea). All blood samples were analysed within 24 h after collection 48 .…”

Section: Methodsmentioning

confidence: 99%

“…Regular exercise was defined as moderate physical activity performed for at least 30 min at a time at least five times a week. Height, weight, and waist circumference were measured by trained medical professionals 48 .The body mass index (BMI) was calculated as body weight (kg) divided by height in meters squared (m 2 ) 49 .…”

Section: Methodsmentioning

confidence: 99%

“…www.nature.com/scientificreports/ were immediately processed and transported to a central laboratory (Neodin Medical Institute, Seoul, South Korea). All blood samples were analysed within 24 h after collection 48 . We used data collected during the 2008-2012 KNHANES.…”

Section: Rapgef2-fstl5 Tcf4-loc100505474 Pcdh10 Kiaa1751 Myo5b Mmentioning

confidence: 99%

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The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Roh

Lee

Kim

et al. 2021

Sci Rep

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While previous studies have reported olfactory dysfunction (OD) in relation to cardiovascular disease (CVD), few population-based studies have investigated whether such associations differ by sex. The purpose of this study was to identify the association between CVD and its risk factors with OD, and the sex-associated differences within the general population. We examined 20,016 adults aged 40 and older from the Korean National Health and Nutrition Examination Survey. All subjects reported on their history of OD. CVD and its risk factors included coronary artery disease (CAD), stroke, hypertension, diabetes, obesity, abdominal obesity, and hypertriglyceridemia; logistic regression was used to analyse their associations with OD, and additive interaction was used to analyse the interaction between risk factors and sex. In males, CAD was more likely to be associated with OD (odds ratio [OR] 1.81, 95% confidence interval [CI] 1.05–3.14), whereas abdominal obesity was associated with OD in females (OR 1.39, 95% CI 1.06–1.84).Additive interaction were observed between abdominal obesity and female sex with a relative excess risk of interaction of 0.45 (95% CI 0.26–0.63). Our findings suggest the relationship between OD and CVD and its risk factors and sex-associated differences among middle-aged and older adults.

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Section: Methodsmentioning

confidence: 99%

Section: Methodsmentioning

confidence: 99%

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The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

Roh

Lee

Kim

et al. 2021

Sci Rep

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“…Different mechanisms, about how microbiota may influence and regulate the innate and adaptive immune responses with emphasis on the Th2 pathway, have been reviewed in detail in our previous AllergoOncology Position Paper [110]. One study showed that germ-free mice have elevated total IgE levels, resulting Age [164] Childcare [165] Gender [92,94] Number of siblings [166] Race [95] Socio-economic status [95] Allergen immunotherapy [167] Corticosteroids [103] Dupilumab [102] Ligelizumab [101] Omalizumab [99] Rituximab [168] Air pollution [169] Microbiota [110,112] Smoking [166] Vitamin D level [ • Due to current minimal information in the field, we cannot specify screening tests or establish recommendations for patients with IgE deficiency. However, with the goal of understanding the role of diminished IgE in the general population, certain clinical findings (e.g.…”

Section: Microbiota Influences On Ige Levelsmentioning

confidence: 99%

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Ferastraoaru

Bax

Bergmann³

et al. 2020

Clin Transl Allergy

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Elevated serum IgE levels are associated with allergic disorders, parasitosis and specific immunologic abnormalities. In addition, epidemiological and mechanistic evidence indicates an association between IgE-mediated immune surveillance and protection from tumour growth. Intriguingly, recent studies reveal a correlation between IgE deficiency and increased malignancy risk. This is the first review discussing IgE levels and links to pathological conditions, with special focus on the potential clinical significance of ultra-low serum IgE levels and risk of malignancy. In this Position Paper we discuss: (a) the utility of measuring total IgE levels in the management of allergies, parasitosis, and immunodeficiencies, (b) factors that may influence serum IgE levels, (c) IgE as a marker of different disorders, and d) the relationship between ultra-low IgE levels and malignancy susceptibility. While elevated serum IgE is generally associated with allergic/atopic conditions, very low or absent IgE may hamper anti-tumour surveillance, indicating the importance of a balanced IgE-mediated immune function. Ultra-low IgE may prove to be an unexpected biomarker for cancer risk. Nevertheless, given the early stage of investigations conducted mostly in patients with diseases that influence IgE levels, in-depth mechanistic studies and stratification of malignancy risk based on associated demographic, immunological and clinical co-factors are warranted.

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“…Two previous longitudinal studies reported that physical activity was not associated with asthma incidence among middle-aged and older women [11, 12], whereas a Finnish cohort study showed that physical activity had a protective effect on asthma onset in men [10]. Furthermore, previous studies have indicated the possibility of sex differences in the effects of smoking and drinking on asthma development [13, 14], but the available population-based studies are insufficient, particularly for older people.…”

Section: Introductionmentioning

confidence: 99%

Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort

2019

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BackgroundThis study investigated the sex-specific incidence of asthma and the effects of modifiable risk factors, particularly obesity, on asthma incidence among middle-aged and older individuals in Korea.MethodsWe used data from the National Health Insurance Service-Health Screening Cohort (NHIS-HEALS), which includes health examinees aged 40–79 years in 2002–2003. In total, 459,529 participants with baseline anthropometric measurements were followed-up for 10 years and the development of asthma was evaluated (2004–2013). For subgroup analysis, 246,019 participants who had body mass index (BMI) and waist circumference (WC) measurements taken in 2008–2009 were included in the analysis of the asthma incidence for 2010–2013. Factors associated with asthma were analysed using Cox proportional hazard models.ResultsThe cohort comprised 4,248,813 (men, 2,358,541; women, 1,890,272) person-years of follow-up for 2004–2013. The asthma incidence was 10.58 and 15.03 per 1000 person-years for men and women, respectively. Asthma incidence increased with age, notably so in men. Obesity based on the baseline BMI was significantly associated with asthma development in both sexes (men, HR = 1.23, 95% confidence interval (CI) = 1.13–1.34; women, HR = 1.40 95% CI = 1.32–1.48). High WC was also related to asthma incidence in both sexes with statistical significance (men, HR = 1.34, 95% CI = 1.16–1.57; women, HR = 1.19 95% CI = 1.03–1.37). Analysis of the combined effects of BMI and WC showed that men had a higher asthma risk in the group with both general obesity and abdominal obesity than in the group with non-abdominal obesity and normal BMI. However, obese women had a higher risk of asthma regardless of abdominal obesity. Similarly, smoking was associated with asthma in both sexes but drinking and physical activity showed different associations between the sexes.ConclusionsOur results revealed that asthma incidence was substantially high at old age and lifestyle factors were associated with asthma development. Practical strategies including weight control and healthy lifestyle modification are required to prevent asthma in older people.

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Sex difference in IgE sensitization associated with alcohol consumption in the general population

Cited by 7 publications

References 56 publications

The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

The association between olfactory dysfunction and cardiovascular disease and its risk factors in middle-aged and older adults

AllergoOncology: ultra-low IgE, a potential novel biomarker in cancer—a Position Paper of the European Academy of Allergy and Clinical Immunology (EAACI)

Sex differences in the association between asthma incidence and modifiable risk factors in Korean middle-aged and older adults: NHIS-HEALS 10-year cohort

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