Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination

Melo, Zesergio; Gutiérrez-Mercado, Y.K.; Garcia-Martínez, David; Buen, Eliseo Portilla-de; Canales-Aguirre, Alejandro A.; González-González, Ricardo; Franco-Acevedo, Adriana; Palomino, J.C.; Echavarría, Raquel

doi:10.1016/j.trim.2020.101331

Cited by 10 publications

(4 citation statements)

References 57 publications

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“…Thus, we cannot rule out that our strain choice is associated with a high prevalence of cardiovascular events. Likewise, female mice exhibit tolerance to renal damage in various animal models, and multiple studies have revealed the presence of sexual dimorphisms throughout the Cardiovascular System in health and disease [ [35] , [36] , [37] ]. A significant limitation of our study is that we only evaluated transcriptomic changes in male C57BL/6 mice, which introduces bias into our findings.…”

Section: Discussionmentioning

confidence: 99%

Cardiac transcriptomic changes induced by early CKD in mice reveal novel pathways involved in the pathogenesis of Cardiorenal syndrome type 4

Munguia-Galaviz,

Gutierrez-Mercado,

Miranda-Diaz

et al. 2024

Heliyon

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Section: Discussionmentioning

confidence: 99%

Cardiac transcriptomic changes induced by early CKD in mice reveal novel pathways involved in the pathogenesis of Cardiorenal syndrome type 4

Munguia-Galaviz,

Gutierrez-Mercado,

Miranda-Diaz

et al. 2024

Heliyon

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“…Successful ovariectomy was confirmed by the cessation of estrus cycles and a decreased plasma E2 level. The time necessary for endogenous hormonal decline ranges from one to 6 weeks (Chung et al, 2010; Melo et al, 2020). In addition, the vulnerability of the female rat hearts to mI/R injury was observed 4 weeks after ovariectomy (Ek et al, 2008).…”

Section: Methodsmentioning

confidence: 99%

Protective effect of propolis on myocardial ischemia/reperfusion injury in males and ovariectomized females but not in intact females

Kaya

Ağan

et al. 2022

Journal of Food Biochemistry

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The aim of this study is to investigate the effect of propolis, which may have estrogenic effects, on myocardial ischemia/reperfusion (mI/R) injury not only in male rats but also in intact and ovariectomized (ovx) female rats. Six groups were formed: untreated males (n = 8), treated males (n = 9), untreated intact females (n = 9), treated intact females (n = 10), untreated ovx females (n = 10), and treated ovx females (n = 8).An alcoholic extract of a single dose of propolis (200 mg/kg) was administered orally daily for 14 days. Thirty minutes of ischemia and 120 min of reperfusion were performed. Blood pressure, heart rate, arrhythmias (ventricular premature contraction[VPC], ventricular tachycardia [VT], ventricular fibrillation [VF]), and myocardial infarct size were evaluated. Total antioxidant status (TAS), total oxidant status (TOS), superoxide dismutase (SOD), catalase (CAT), glutathione peroxidase (GPx), and 17 beta-estradiol (E2) were measured. The untreated females showed more resistance to mI/R injury than the untreated males, as evidenced by lower duration, incidence, and score of arrhythmias, and smaller infarct size (p < .05). After ovx, this resistance disappeared. Propolis improved these values in treated males and treated ovx females (p < .05). Propolis increased TAS in treated males and decreased TOS in treated ovx females as well as elevated SOD in all treated groups (p < .05). Propolis decreased E2 level in treated intact females; however, it increased E2 level in treated ovx females (p < .05). The results revealed that propolis could protect the heart against mI/R injury in males and ovx females. Practical applicationsIt is known that the female heart has an increased sensitivity to myocardial ischemia/ reperfusion (mI/R) injury due to estrogen deficiency and/or estrogen deprivation following menopause or surgical removal of the ovaries. Propolis has the potential to mimic estrogen under physiological and pathophysiological conditions, as well as its antioxidant property. The results indicated that propolis decreased myocardial infarct size, arrhythmia score, arrhythmia duration, and incidence in ovariectomized female rats and male rats. In addition, the present results demonstrated that an alcoholic

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“…In addition, it was found that the expression level of PAD4 mRNA in the kidney was sex dependent [ 84 ]. In male kidneys, circulating citH3 levels increased after IR injury, with elevated citH3-DNA interactions mediated by PAD4 and eventual release of large amounts of neutrophil extracellular trap; whereas in female kidneys, citH3 was found to remain accumulated in the cytoplasm of epithelial cells, with decreased levels of circulating citH3 and reduced neutrophil extracellular trap formation [ 85 ]. Therefore, it is reasonable to speculate that estrogen alleviates the renal damage posed by IR in women by reducing neutrophil infiltration through modulation of PAD4.…”

Section: Histone Citrullination In Akimentioning

confidence: 99%

Histone Modifications in Acute Kidney Injury

et al. 2022

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Background: Acute kidney injury( AKI) is a serious clinical problem associated with high morbidity and mortality worldwide. The pathophysiology and pathogenesis of AKI is complex and multifactorial. In recent years, epigenetics has emerged as an important regulatory mechanism in AKI. Summary: There are several types of histone modification, including methylation, acetylation, phosphorylation, crotonylation, citrullination, and sumoylation. Histone modifications are associated with the transcription of many genes and activation of multiple signaling pathways that contribute to the pathogenesis of AKI. Thus, targeting histone modification may offer novel strategies to protect kidneys from AKI and enhance kidney repair and recovery. In this review, we summarize recent advances on the modification, regulation, and implication of histone modifications in AKI. Key Messages: Histone modifications contribute to the pathogenesis of AKI. Understanding of epigenetic regulation in AKI will aid in establishing the utility of pharmacologic targeting of histone modification as a potential novel therapy for AKI.

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Sex-dependent mechanisms involved in renal tolerance to ischemia-reperfusion: Role of inflammation and histone H3 citrullination

Cited by 10 publications

References 57 publications

Cardiac transcriptomic changes induced by early CKD in mice reveal novel pathways involved in the pathogenesis of Cardiorenal syndrome type 4

Cardiac transcriptomic changes induced by early CKD in mice reveal novel pathways involved in the pathogenesis of Cardiorenal syndrome type 4

Protective effect of propolis on myocardial ischemia/reperfusion injury in males and ovariectomized females but not in intact females

Histone Modifications in Acute Kidney Injury

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