Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains

Kile, Benjamin T.; Mason-Garrison, Cammy L.; Justice, Monica J.

doi:10.1007/s00335-002-2160-0

Cited by 42 publications

(31 citation statements)

References 5 publications

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“…These reductions in IL-6 levels are comparable to the reductions in IL-1␤ levels, indicating the effectiveness of apigenin in reducing the expression levels of multiple pro-inflammatory cytokines in irradiated mice. [39]. After exposure to a single dose of 3 Gy of 137 Cs ␥ rays, the N/L ratio increased by 3.4-and 2.7-fold at days 3 and 10, respectively.…”

Section: Levels Of Nf-äb In Bmdmsmentioning

confidence: 97%

Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Rithidech

Tungjai

Reungpatthanaphong

et al. 2012

Mutation Research/Genetic Toxicology and Environmental Mutagene

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Section: Levels Of Nf-äb In Bmdmsmentioning

confidence: 97%

Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Rithidech

Tungjai

Reungpatthanaphong

et al. 2012

Mutation Research/Genetic Toxicology and Environmental Mutagene

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“…The 95% range of the values was similar to the data range including two standard deviations above and below the mean, which indicated the Gaussian distribution of the data. Compared with published blood glucose values from experiments carried out in a short time period and/or using small numbers of animals (http:// jax.org/phenome) (25), the range of the values varied broadly, leading to high standard deviations. This may have been due to the increased influence of environmental and experimental changes in long-term studies.…”

Section: Phenotypic Screen For Hyperglycemiamentioning

confidence: 99%

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects

Aigner

Rathkolb²,

Herbach³

et al. 2008

American Journal of Physiology-Endocrinology and Metabolism

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Aigner B, Rathkolb B, Herbach N, Hrabé de Angelis MH, Wanke R, Wolf E. Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects. Am J Physiol Endocrinol Metab 294: E232-E240, 2008. First published December 4, 2007 doi:10.1152/ajpendo.00592.2007.-More than 150 million people suffer from diabetes mellitus worldwide, and this number is expected to rise substantially within the next decades. Despite its high prevalence, the pathogenesis of diabetes mellitus is not completely understood. Therefore, appropriate experimental models are essential tools to gain more insight into the genetics and pathogenesis of the disease. Here, we describe the current efforts to establish novel diabetes models derived from unbiased, phenotype-driven, large-scale N-ethyl-N-nitrosourea (ENU) mouse mutagenesis projects started a decade ago using hyperglycemia as a high-throughput screen parameter. Mouse lines were established according to their hyperglycemia phenotype over several generations, thereby revealing a mutation as cause for the aberrant phenotype. Chromosomal assignment of the causative mutation and subsequent candidate gene analysis led to the detection of the mutations that resulted in novel alleles of genes already known to be involved in glucose homeostasis, like glucokinase, insulin 2, and insulin receptor. Additional ENU-induced hyperglycemia lines are under genetic analysis. Improvements in screen for diabetic animals are implemented to detect more subtle phenotypes. Moreover, diet challenge assays are being employed to uncover interactions between genetic and environmental factors in the pathogenesis of diabetes mellitus. The new mouse mutants recovered in phenotype-driven ENU mouse mutagenesis projects complement the available models generated by targeted mutagenesis of candidate genes, all together providing the large resource of models required for a systematic dissection of the pathogenesis of diabetes mellitus. clinical chemistry; N-ethyl-N-nitrosourea; glucose; insulin TYPE 2 DIABETES MELLITUS (T2DM) is characterized by uncontrolled hyperglycemia caused by both insulin resistance and pancreatic ␤-cell dysfunction. Human T2DM is usually a polyfactorial disease resulting from the interaction of genetic susceptibility and environmental factors. The prevalence of diabetes mellitus has reached an alarming dimension in industrialized countries and is expected to rise substantially within the next decades. Diabetes leads to a reduced quality of life and life expectancy by causing increased risk for blindness, cardiovascular disease, nephropathy, and neuropathy (53). Despite its high prevalence, the pathogenesis of diabetes mellitus is not completely understood. Diabetic mouse mutants are used to identify genes and pathways that regulate glucose homeostasis, contribute to the susceptibility to diabetes, and affect the development and severity of secondary complications. Thus, these models are important to gain insights into all aspects of the pathophysiology of diabetes and also for ...

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“…Such mice are classified according to their respective mouse strains characteristics, such as hair color, blood parameters, biological behavior, immune response, response to stress, disease susceptibility ( e.g. , atherosclerosis, diabetes mellitus and its complications, and cancer), gene knockout, and a variety of trait-specific responses (Table 1) [4567891011121314]. …”

mentioning

confidence: 99%

Use of C57BL/6N mice on the variety of immunological researches

Song

Hwang

2017

Lab Anim Res

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Inbred mice are an essential animal strain for research as they can improve the reproducibility and reliability of study results. The establishment of new inbred lines is continuing, and new inbred lines are being used in many research fields. C57BL/6 is a mouse laboratory animal that has been developed and used as an inbred strain since early stage of mouse strain development, and, in the 1950s, C57BL/6 was separated into substrains by the Jackson Laboratory (C57BL/6J) and the National Institutes of Health (C57BL/6N). C57BL/6 mice have been used in immunology and antitumor activity studies since the early strain development stage. After the mouse genome was fully described, C57BL/6 mice use in many areas of research has expanded. In particular, immunological characteristics such as those related to cell-mediated immunity and NK cell activity are relatively higher in C57BL/6 mice than in other mice. The C57BL/6NKorl is a stock of C57BL/6N established as part of a localization of experimental animal strategy of the Korean Food and Drug Administration. Based on analysis of single nucleotide polymorphisms (SNPs), C57BL/6NKorl is considered a genetically distinct inbred stock from other C57BL/6N. Various research efforts have been made to describe the characteristics and increase knowledge of the characteristics of C57BL/6Nkorl. The results obtained through these efforts are expected to increase the utilization of C57BL/6Nkorl as a domestic laboratory animal resource and to enhance the reliability of mouse based studies.

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Sex and strain-related differences in the peripheral blood cell values of inbred mouse strains

Cited by 42 publications

References 5 publications

Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Attenuation of oxidative damage and inflammatory responses by apigenin given to mice after irradiation

Diabetes models by screen for hyperglycemia in phenotype-driven ENU mouse mutagenesis projects

Use of C57BL/6N mice on the variety of immunological researches

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