Sex and racial disparities in catheter ablation

Special issue on electrophysiology and arrhythmia management around the globe: Challenges and opportunities explored

“…While the incidence of AF is lower in ethnic minorities, mortality benefit from ablation is higher compared to the white population. 11 Vanderberk et al 12 review the sex and racial disparities in electrophysiology and present data on sex differences in ion channel expression. Female ventricular myocytes have longer action potential duration because of reduced expression of rapid delayed rectifier potassium channels by estrogen; testosterone is associated with stronger transient outward currents in the male ventricular epicardium.…”