Effectiveness of the risk stratification proposed by the 2022 European Heart Rhythm Association Expert Consensus statement on arrhythmic mitral valve prolapse

L'Hoyes, Wouter; Robyns, Tomas; Moura-Fereira, Sara; De Meester, Pieter; Dresselaers, Tom; Herregods, Marie-Christine; Rega, Filip; Masci, Pier Giorgio; Willems, Rik; Bogaert, Jan; Vandenberk, Bert

doi:10.1016/j.ahj.2023.08.004

Cited by 4 publications

(5 citation statements)

References 31 publications

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“…The aim of this retrospective analysis was to report the clinical evolution of the small subset of patients with MVP or MAD included in our registry who underwent serial CMR [4].…”

Section: Of 11mentioning

confidence: 99%

“…This single-center retrospective analysis includes all patients in our MVP and MAD registry who underwent >1 CMR with assessment of late gadolinium enhancement (LGE) and >1 24 h Holter recording at our institution between January 2008 and September 2023. The design and outcome of our single-center MVP registry have been published previously [4]. In brief, all consecutive patients with MVP and/or MAD who underwent a CMR at our institution were included in the registry.…”

Section: Study Populationmentioning

confidence: 99%

“…Clinical data, including demographics, pharmacological changes and electrocardiographic evolution, were collected by reviewing the electronic medical record as reported previously [4]. In brief, the clinical presentation, medical history, and medication were collected at the time of baseline CMR.…”

Section: Baseline and Follow-up Clinical Datamentioning

confidence: 99%

“…MAD was quantified as the longitudinal length in the long axis view [3,7]. The severity of MVP was corrected for the length of the MAD, if MAD was present [4]. Phase-contrast velocity-encoded CMR imaging of the aortic outflow tract was performed to quantify aortic forward flow and indirectly quantify MR volume.…”

Section: Cmr Imaging Protocol and Analysismentioning

confidence: 99%

“…While the incidence for severe arrhythmic events in patients with uncomplicated MVP is rather low at 0.3%/year (95% CI 0.1-0.8), higher incidences up to 4%/year (95% CI 2-9) have been reported in patients with arrhythmic mitral valve prolapse (AMVP) [2]. These reports resulted in an increased attention for risk stratification for SCD in this population [3,4].…”

Section: Introductionmentioning

confidence: 99%

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Serial Cardiac Magnetic Resonance Imaging in Patients with Mitral Valve Prolapse—A Single-Center Retrospective Registry

Blondeel,

L’Hoyes,

Robyns

et al. 2024

JCM

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Background: Mitral valve prolapse (MVP) and mitral annular disjunction (MAD) are common valvular abnormalities that have been associated with ventricular arrhythmias (VA). Cardiac magnetic resonance imaging (CMR) has a key role in risk stratification of VA, including assessment of late gadolinium enhancement (LGE). Methods: Single-center retrospective analysis of patients with MVP or MAD who had >1 CMR and >1 24 h Holter registration available. Data are presented in detail, including evolution of VA and presence of LGE over time. Results: A total of twelve patients had repeated CMR and Holter registrations available, of which in four (33%) patients, it was conducted before and after minimal invasive mitral valve repair (MVR). After a median of 4.7 years, four out of eight (50%) patients without surgical intervention had new areas of LGE. New LGE was observed in the papillary muscles and the mid to basal inferolateral wall. In four patients, presenting with syncope or high-risk non-sustained ventricular tachycardia (VT), programmed ventricular stimulation was performed and in two (50%), sustained monomorphic VT was easily inducible. In two patients who underwent MVR, new LGE was observed in the basal inferolateral wall of which one presented with an increased burden of VA. Conclusions: In patients with MVP and MAD, repeat CMR may show new LGE in a small subset of patients, even shortly after MVR. A subgroup of patients who presented with an increase in VA burden showed new LGE upon repeat CMR. VA in patients with MVP and MAD are part of a heterogeneous spectrum that requires further investigation to establish risk stratification strategies.

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“…The aim of this retrospective analysis was to report the clinical evolution of the small subset of patients with MVP or MAD included in our registry who underwent serial CMR [4].…”

Section: Of 11mentioning

confidence: 99%

Section: Study Populationmentioning

confidence: 99%

Section: Baseline and Follow-up Clinical Datamentioning

confidence: 99%