Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats

Li, Yan Qin; Wang, Xiao Yi; Zhai, Hai Feng; Zhang, Xiang Yang; Kosten, Therese A.; Lü, Lin

doi:10.1016/j.bbr.2007.07.028

Cited by 5 publications

(4 citation statements)

References 30 publications

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“…Consistent with our previous report (Li et al 2008), EPSD had no significant effects on body weight or individual physiological development including ear unfolding, eye opening, testis descent, and vaginal opening (data not shown).…”

Section: Effects Of Epsd On Physiological Developmentsupporting

confidence: 93%

“…The results of the present study demonstrate that EPSD did not affect body weight or physical development of pups (Li et al 2008). However, EPSD on PN1, but not PN7, changed maternal licking/grooming behavior in the first postnatal week.…”

Section: Discussionmentioning

confidence: 70%

“…Using the new early postnatal sibling deprivation (EPSD) paradigm, we recently found that deprivation of siblings in early life causes sex-and age-dependent effects on spatial learning and memory in adult rats (Li et al 2008). However, little is known about the effect of deprivation of sibling interaction on anxiety-like behavior and vulnerability to drug abuse.…”

Section: Introductionmentioning

confidence: 98%

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Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Wang

Zhai

et al. 2008

Psychopharmacology

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Section: Effects Of Epsd On Physiological Developmentsupporting

confidence: 93%

Section: Discussionmentioning

confidence: 70%

Section: Introductionmentioning

confidence: 98%

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Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Wang

Zhai

et al. 2008

Psychopharmacology

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“…The MWM procedure was based on a previous study 55 . A circular black-painted swimming pool (diameter: 1.5 m) was divided into four equal quadrants (Q1, Q2, Q3, and Q4) and a black escape platform was placed 2 cm below the water surface in the center of Q4.…”

Section: Methodsmentioning

confidence: 99%

Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Chen

Meng

Xue

et al. 2016

Sci Rep

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Cognition is impacted by aging. However, the mechanisms that underlie aging-associated cognitive impairment are unclear. Here we showed that cognitive decline in aged rats was associated with changes in DNA methylation of protein kinase Mζ (PKMζ) in the prelimbic cortex (PrL). PKMζ is a crucial molecule involved in the maintenance of long-term memory. Using different behavioral models, we confirmed that aged rats exhibited cognitive impairment in memory retention test 24 h after training, and overexpression of PKMζ in the PrL rescued cognitive impairment in aged rats. After fear conditioning, the protein levels of PKMζ and the membrane expression of GluR2 increased in the PrL in young and adult rats but not in aged rats, and the levels of methylated PKMζ DNA in the PrL decreased in all age groups, whereas the levels of unmethylated PKMζ DNA increased only in young and adult rats. We also found that environmentally enriched housing reversed the hypermethylation of PKMζ and restored cognitive performance in aged rats. Inactivation of PKMζ prevented the potentiating effects of environmental enrichment on memory retention in aged rats. These results indicated that PKMζ might be a potential target for the treatment of aging-related cognitive impairment, suggesting a potential therapeutic avenue.

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Effects of early social separation on the behaviour of kittens of the domestic cat

Martínez-Byer¹,

Hudson

Bánszegi

et al. 2023

Applied Animal Behaviour Science

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Sex- and age-dependent effects of early postnatal sibling deprivation on spatial learning and memory in adult rats

Cited by 5 publications

References 30 publications

Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Effects of early postnatal sibling deprivation on anxiety and vulnerability to cocaine in offspring rats

Epigenetic modification of PKMζ rescues aging-related cognitive impairment

Effects of early social separation on the behaviour of kittens of the domestic cat

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