Sevoflurane analysis in forensic cases using headspace-gas chromatography-mass spectrometry: A case study

Riasat, Madiha; Chaudhary, Muhammad Taimoor; Jamshaid, Tahir

doi:10.1016/j.toxac.2022.06.272

Cited by 1 publication

(1 citation statement)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This technique allows us to analyze sevoflurane quantitatively in an aqueous solution or in biological fluid, blood, and urine. [ 16 17 18 ] GC has also been used in different stability studies of sevoflurane to detect the degradation products, on the other hand, the GC method is a rather complicated instrument that needs time in operation and maintenance, therefore, an attempt to use another simple technique. In this work, the attenuated total reflectance infrared (ATR-IR)-spectrometer was used particularly for qualitative and quantitative analysis of formulated sevoflurane.…”

Section: Introductionmentioning

confidence: 99%

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Hasson

2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

Sevoflurane, also called fluoromethyl ether, is an inhalation anesthetic agent used to initiate and maintain general anesthesia for adults and pediatric patients during surgical procedures. Several analytical methods have previously been applied to follow the properties and quality of sevoflurane, including mass spectrometry and gas chromatography methods. These methods are practically tedious and need sophisticated apparatus. In the present work, an attenuated total reflectance–Fourier transform infrared (ATR-FTIR) spectrometric method was used for the quantitative determination of sevoflurane which is characterized as a fast, accurate, and available technique for most pharmaceutical laboratories, besides the gas chromatographic method which is the most suitable for the detection of impurities. Sevoflurane is a liquid and it is applied directly on the glass top of the ATR-FTIR either as a concentrated solution or diluted with hexane as a diluent, which did not interfere with sample determination within the specified wavelength range of the IR spectrum, particularly the wavelength of the ethereal group at 1200 cm−1. This method can be applied to the identification test and quantitative assay of sevoflurane since it is validated for the precision, accuracy, reproducibility, and specificity in the analysis of sevoflurane as a pharmaceutical product. However, still, there is a need for a gas chromatographic method to detect the impurities and degradation products during the stability study of sevoflurane.

show abstract

Section: Introductionmentioning

confidence: 99%

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Hasson

2024

Journal of Advanced Pharmaceutical Technology &Amp; Research

View full text Add to dashboard Cite

show abstract

Sevoflurane analysis in forensic cases using headspace-gas chromatography-mass spectrometry: A case study

Cited by 1 publication

References 0 publications

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Stability study and development of the validated infrared spectrometric method for quantitative analysis of sevoflurane compared with the gas chromatographic method

Contact Info

Product

Resources

About