2013
DOI: 10.1590/0074-0276108052013021
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Severity of tegumentary leishmaniasis is not exclusively associated with Leishmania RNA virus 1 infection in Brazil

Abstract: Leishmania RNA virus (LRV) has been shown to be a symbiotic component of Leishmania parasites in South America. Nested retro-transcription polymerase chain reaction was employed to investigate LRV1 presence in leishmaniasis lesions from Brazil. In endemic areas of Rio de Janeiro (RJ), no LRV1 infection was observed even with mucosal involvement. LRV1 was only detected in Leishmania (V.) guyanensis cutaneous lesions from the northern region, which were obtained from patients presenting with disease reactivation… Show more

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Cited by 56 publications
(65 citation statements)
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“…This could thus explain the large difference of prevalence observed between our results and those previously published. [18][19][20]22 We here report the detection of LRV1 from different L. guyanensis and L. braziliensis isolates. 7,10,[18][19][20] None of the six L. amazonensis isolates tested were positive for LRV1.…”
Section: Discussionmentioning
confidence: 88%
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“…This could thus explain the large difference of prevalence observed between our results and those previously published. [18][19][20]22 We here report the detection of LRV1 from different L. guyanensis and L. braziliensis isolates. 7,10,[18][19][20] None of the six L. amazonensis isolates tested were positive for LRV1.…”
Section: Discussionmentioning
confidence: 88%
“…Indeed, in Colombia, the virus was detected from parasites originating from the Amazon area of the country whereas no virus was detected in other regions. 18 In Brazil, Pereira and others 22 reported two LRV1 positive isolates of 48 tested (4.1%). These two L. guyanensis positive isolates were from the Amazon region.…”
Section: Discussionmentioning
confidence: 96%
See 1 more Smart Citation
“…13,16,19,21 Despite the detection of LRV1 in large metastatic strains of L. braziliensis and L. guyanensis, metastases may occur in its absence. 19,22 LRV discovery as an innate immunogen, changing the course of leishmaniosis, should motivate further research on such viral hyperpathogens in other infections. 19 The methods routinely used in the diagnosis of cutaneous leishmaniosis are limited for mucosal lesions.…”
Section: Introductionmentioning
confidence: 99%
“…gold standard), 12 because of its sensitivity and specificity, especially to establish parasite species 24 and also to detect LRV1. 22,25 Given the relevant research on LRV1 conducted by Ives 13 on the definition of the mucosal leishmaniosis phenotype in mice, and also considering also scarcity of information on the presence of this virus and clinical manifestations in patients, it was decided to study the existence of clinical differences in patients with ML with or without LRV1 endosymbiosis. We hope that this will contribute to the continuing education process for health professionals working with this very challenging disease, that still represents a major public health problem in Brazil.…”
Section: Introductionmentioning
confidence: 99%