Severity of dysfluency correlates with basal ganglia activity in persistent developmental stuttering

Giraud, Anne-Lise; Neumann, Katrin; Bachoud‐Lévi, Anne‐Catherine; Gudenberg, Alexander W. von; Euler, Harald Α.; Lanfermann, Heinrich; Preibisch, Christine

doi:10.1016/j.bandl.2007.04.005

Cited by 181 publications

(181 citation statements)

References 54 publications

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“…In previous research, researchers tried to use correlation analysis to separate stutteringrelated neural system from that for normal speech (e.g., Braun et al, 1997;Fox et al, 2000). Their results have been inconsistent (Braun et al, 1997;Fox et al, 2000;Giraud et al, 2008;Ingham et al, 2004). By separating the planning and execution processes, our results can help to shed light on the possible reasons for the inconsistenies.…”

Section: Discussionmentioning

confidence: 86%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

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a b s t r a c t a r t i c l e i n f oUsing an fMRI-based classification approach and the structural equation modeling (SEM) method, this study examined the neural bases of atypical planning and execution processes involved in stuttering. Twelve stuttering speakers and 12 controls were asked to name pictures under different conditions (single-syllable, multi-syllable, or repeated-syllable) in the scanner. The contrasts between conditions provided information about planning and execution processes. The classification analysis showed that, as compared to nonstuttering controls, stuttering speakers' atypical planning of speech was evident in their neural activities in the bilateral inferior frontal gyrus (IFG) and right putamen and their atypical execution of speech was evident in their activations in the right cerebellum and insula, left premotor area (PMA), and angular gyrus (AG). SEM results further revealed two parallel neural circuits-the basal ganglia-IFG/PMA circuit and the cerebellum-PMA circuit-that were involved in atypical planning and execution processes of stuttering, respectively. The AG appeared to be involved in the interface of atypical planning and execution in stuttering. These results are discussed in terms of their implications to the theories about stuttering and to clinical applications.

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Section: Discussionmentioning

confidence: 86%

The neural substrates for atypical planning and execution of word production in stuttering

Chen

Ning

et al. 2010

Experimental Neurology

View full text Add to dashboard Cite

show abstract

“…In the present results, stuttering speakers showed a stronger projection from the putamen to the thalamus than did non-stuttering speakers. This result makes sense because the basal ganglia have been found to correlate positively to the stuttering rate (in the case of the putamen) (Braun et al, 1997) and stuttering severity (in the case of the caudate nucleus) (Giraud et al, 2008). Further, the correlation disappeared when stuttering is improved (Giraud et al, 2008).…”

Section: Connectivity From the Basal Ganglia To The Thalamusmentioning

confidence: 84%

“…In addition to ML discrepancy function, there are other alternative fit indices such as the Root Mean Square Error of Approximation (RMSEA), Comparative Fit Index (CFI), and Parsimony Goodness of Fit Index (PGFI) (Browne and Cudeck, 1993;Steiger and Lind, 1980). They have been used in neuroimaging studies as well (Au Duong et al, 2005;Bentler, 1990;Goncalves et al, 2001;Honey et al, 2003;Schlosser et al, 2006;Zhuang et al, 2005). Besides the overall fit indices, the reported t value for each path coefficient in the model should be greater than a certain critical value to reject the null hypothesis that the coefficient is 0.…”

Section: Semmentioning

confidence: 99%

“…1) is the neural network involved in stuttering. Previous research showed that stuttering and non-stuttering speakers differ significantly in activation patterns in the BGTC, especially in the left frontal motor cortex, the temporal cortex, and the basal ganglia (e.g., Braun et al, 1997;Brown et al, 2005;De Nil et al, 2003;Fox et al, 1996;Giraud et al, 2008;Ingham et al, 2000). Within the frontal motor cortex, the supplementary motor area (SMA, including both the SMA proper and anterior supplementary motor area -preSMA) may play a special role.…”

Section: Introductionmentioning

confidence: 99%

“…Since its introduction by McIntosh et al (1994), neural connectivity analysis has been used in a wide range of functional MRI studies (e.g., Bü chel and Friston, 1997;Doeller et al, 2006;Fu et al, 2006;Goncalves et al, 2001;Honey et al, 2003;Iidaka et al, 2006;Schlosser et al, 2006;Zhuang et al, 2005). Several multivariate techniques have been employed to investigate effective connectivity.…”

Section: Introductionmentioning

confidence: 99%

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