Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers

Lu, Chunming; Peng, Danling; Chen, Chuansheng; Ning, Ning; Ding, Guiguang; Li, Kuncheng; Yang, Yanhui; Lin, Chunlan

doi:10.1016/j.cortex.2009.02.017

Cited by 139 publications

(126 citation statements)

References 126 publications

(169 reference statements)

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“…The results of our study did not replicate the changes of increased left STG (Beal et al, 2007). However, Lu et al (2010) found that the GM volume in the left STG in PWS was lower than that in the controls. Therefore, it is evident that no reproducible changes in the left STG were found in PWS.…”

Section: Altered Tonotopy In Pwscontrasting

confidence: 77%

“…Although there have been many VBM studies of PWS (Jäncke et al, 2004;Beal et al, 2007;Chang et al, 2008;Kell et al, 2009;Lu et al, 2010), there exist considerable methodological differences among studies, and previous studies did not always reproduce the results of former studies. The results of our study did not replicate the changes of increased left STG (Beal et al, 2007).…”

Section: Altered Tonotopy In Pwsmentioning

confidence: 99%

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Spatiotemporal signatures of an abnormal auditory system in stuttering

et al. 2011

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People who stutter (PWS) can reduce their stuttering rates under masking noise and altered auditory feedback; such a response can be attributed to altered auditory input, which suggests that abnormal speech processing in PWS results from abnormal processing of auditory input. However, the details of this abnormal processing of basic auditory information remain unclear. In order to characterize such abnormalities, we examined the functional and structural changes in the auditory cortices of PWS by using a 306-channel magnetoencephalography system to assess auditory sensory gating (P50m suppression) and tonotopic organization. Additionally, we employed voxel-based morphometry to compare cortical gray matter (GM) volumes on structural MR images. PWS exhibited impaired left auditory sensory gating. The tonotopic organization in the right hemisphere of PWS is expanded compared with that of the controls. Furthermore, PWS showed a significant increase in the GM volume of the right superior temporal gyrus, consistent with the right tonotopic expansion. Accordingly, we suggest that PWS have impaired left auditory sensory gating during basic auditory input processing and that some error signals in the auditory cortex could result in abnormal speech processing. Functional and structural reorganization of the right auditory cortex appears to be a compensatory mechanism for impaired left auditory cortex function in PWS.

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Section: Altered Tonotopy In Pwscontrasting

confidence: 77%

Section: Altered Tonotopy In Pwsmentioning

confidence: 99%

Spatiotemporal signatures of an abnormal auditory system in stuttering

et al. 2011

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“…Both lesions of SMA proper and pre-SMA can cause speech dysfluency, problems with pre-articulatory error repair, and impaired control of attention (Alm, 2011). "Stuttering", representing a prototypical kind of dysfluency, seems to be associated with abnormal connectivity patterns between the basal ganglia and pre-SMA (Lu et al, 2010). Further aspects of basal ganglia circuits and SMA with regard to stuttering and speech timing are addressed in a detailed review paper (Alm, 2004).…”

Section: Clinical Aspectsmentioning

confidence: 99%

The role of the supplementary motor area for speech and language processing

Hertrich

Dietrich

Ackermann

2016

Neuroscience & Biobehavioral Reviews

232

130

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“…1 Decades of neuroimaging research have revealed various functional and structural anomalies in people with PDS. [2][3][4][5][6][7][8][9][10] However, these studies cannot differentiate between neural anomalies that are responsible for PDS and those that are a result of compensating for stuttering. 8,9 This is because long-term compensation can result in both functional and structural changes in the brain of PDS patients.…”

mentioning

confidence: 99%

Neural anomaly and reorganization in speakers who stutter

Chen

Peng

et al. 2012

Neurology

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Objectives:The aim of the current study was to differentiate between neural activity that represents neural anomalies that are responsible for persistent developmental stuttering (PDS) from the activity that is a result of compensating for stuttering. This was done by investigating alterations to the intrinsic functional architecture of speech-language processes of patients with PDS before and after a short-term intervention. Methods:The resting-state functional connectivity (RSFC) and cortical thickness were examined before and after the intervention. The structural data were used to validate the functional results. Fifteen stuttering patients who received intervention (PDSϩ), 13 stuttering patients who did not receive intervention (PDSϪ), and 13 fluent controls participated.Results: Before the intervention, both groups of PDS patients showed significant RSFC and cortical thickness reductions in the left pars-opercularis (PO) and RSFC increases in the cerebellum, as compared to fluent controls. The intervention was effective in reducing stuttering in PDSϩ patients and lowering their RSFC in the cerebellum to the level of fluent controls. The intervention effect was specific to the PDSϩ group (it was not evident in the PDSϪ group). The intervention did not change RSFC and cortical thickness in the left PO, which remained at its preintervention level. Conclusions:The results suggest that the left PO is a locus where the intrinsic functional architecture of speech-language processes is altered in PDS patients, suggesting an etiologic role of this region in PDS. The cerebellum showed intervention-induced neural reorganization, suggesting a compensatory response when stuttering occurs. Neurology ® 2012;79:625-632 GLOSSARY AFNI ϭ Analysis of Functional NeuroImages; BA ϭ Brodmann area; EPI ϭ echoplanar image; IC ϭ independent component; ICA ϭ independent component analysis; IFC ϭ inferior frontal cortex; MFG ϭ middle frontal gyrus; OASES ϭ Overall Assessment of the Speaker's Experience of Stuttering; PDS ϭ persistent developmental stuttering; PDS؊ ϭ stuttering patients who did not receive intervention; PDS؉ ϭ stuttering patients who received intervention; PO ϭ pars-opercularis; ROI ϭ region of interest; RSFC ϭ resting-state functional connectivity; SMA ϭ supplementary motor area; SSI-3 ϭ Stuttering Severity Instrument version III; TE ϭ echo time; TR ϭ repetition time.

show abstract

Altered effective connectivity and anomalous anatomy in the basal ganglia-thalamocortical circuit of stuttering speakers

Cited by 139 publications

References 126 publications

Spatiotemporal signatures of an abnormal auditory system in stuttering

Spatiotemporal signatures of an abnormal auditory system in stuttering

The role of the supplementary motor area for speech and language processing

Neural anomaly and reorganization in speakers who stutter

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