Severity assessment of single dose Oxford–AstraZeneca vaccinated individuals infected with SARS CoV-2 in the Southeast Bangladesh

Rana, Eaftekhar Ahmed; Dutta, Pronesh; Islam, Md. Sirazul; Nizami, Tanvir Ahmad; Das, Tridip; Chowdhury, Sharmin; Das, Goutam

doi:10.1101/2021.05.10.21256529

Cited by 2 publications

(3 citation statements)

References 20 publications

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“…The CT severity score has been designed to assess the severity of COVID 19 pneumonia, in patients infected by the SARS-CoV-2 virus. Studies have shown that the use of vaccination reduces the clinical severity of infection by the corona virus even though it might not prevent infection by the virus [4,5]. This has been reflected in the CT severity score of the vaccinated patients in our study.…”

Section: Introductionmentioning

confidence: 59%

See 1 more Smart Citation

Effect of COVID 19 vaccination on the CT severity score for SARS CoV2 pneumonia- an experience from the initial wave.

Batra

Gupta

et al. 2023

Braz. J. Rad. Sci.

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The severe acute respiratory syndrome coronavirus 2 pandemic started in the December of 2019 at China. The second wave of the pandemic in India peaked between April-May 2021. In order to reduce the transmission and infectivity of the virus several vaccines were approved for emergent use. Studies have shown the effectiveness of vaccination in reducing the clinical severity of infection by the corona virus. In this study we aim to assess the effect of vaccination on the computed tomography severity score (CTSS). The study included 140 patients who tested positive for COVID 19 on RT PCR or rapid antigen test. Seventy of these patients had received at least one dose of vaccination and 70 patients were unvaccinated. CT scan of the chest was done for all patients and a CTSS ranging from 0 to 25 was assigned depending on the extent of lobar involvement. We found that a higher percentage (72.86%) of unvaccinated patients had severe disease compared to the vaccinated group (38.57%), 5.71% of unvaccinated patients had mild disease compared to 30% of vaccinated patients. The difference between the two groups was found to be statistically significant. On comparing the CTSS of patients with and without vaccination in our study, we found a significant reduction in the severity scores in the vaccinated group. Through this study the vaccine’s efficacy could be validated objectively. This article aims to emphasize the role of vaccination in our fight against the pandemic caused by the corona virus.

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Section: Introductionmentioning

confidence: 59%

“…Earlier studies have shown a reduction in the clinical severity and hospital admission rates in patients vaccinated against the virus [4,5]. An Indian study done by Atre et al, published in June 2022 also revealed lower mean CTSS in fully vaccinated cohort than in partially vaccinated and unvaccinated cohort.…”

Section: Discussionmentioning

confidence: 90%

Effect of COVID 19 vaccination on the CT severity score for SARS CoV2 pneumonia- an experience from the initial wave.

Batra

Gupta

et al. 2023

Braz. J. Rad. Sci.

View full text Add to dashboard Cite

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“…The continuation of this study on those who received the second dose more than six months ago will provide an appropriate booster interval, risk population category, and overview of herd immunity. According to a recent study conducted in the greater Chattogram division it is evident that administering the first dose (Oxford-AstraZeneca) vaccine significantly reduces health risk during the COVID-19 infection phase [ 54 ]. So, it is evident that similar research is clamoring for justifications for booster administration.…”

Section: Discussionmentioning

confidence: 99%

Sero-prevalence of anti-SARS-CoV-2 antibodies in Chattogram Metropolitan Area, Bangladesh

Ara

Islam

Kader

et al. 2022

Preprint

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Background: Seroprevalence studies of coronavirus disease 2019 (COVID-19) assess the degree of undetected transmission in the community. Different groups, such as healthcare workers (HCWs), garment workers, and others, are deemed vulnerable due to their workplace hazards and immense responsibility. Purpose: The present study was conducted to estimate the seroprevalence of anti-SARS-CoV-2 antibody (IgG) and its association with different explanatory variables. Further, the antibody was quantified to assess the increasing or decreasing trend over different intervention periods and according to other factors. Methodology: This cross-sectional study observed health workers - doctor, nurse, hospital staff, etc. in and outpatients (non-COVID-19) and garments workers of Chattogram metropolitan area (CMA, N=748) from randomly selected six government and private hospitals and two garment factories. Study subjects were included upon written consent, fulfilling specific inclusion criteria. Venous blood was collected following standard aseptic methods. Qualitative and quantitative ELISA was used to identify and quantify antibodies (IgG) in serum samples. Descriptive, univariable, and multivariable statistical analysis was performed. Results: Overall seroprevalence was estimated as 66.99% (95% CI: 63.40%-70.40%). Seroprevalence among HCWs, in and outpatients, and garments workers were 68.99 % (95% CI: 63.8%-73.7%), 81.37 % (95% CI: 74.7%-86.7%), and 50.56 % (95% CI: 43.5%-57.5%), respectively. Seroprevalence was 44.47 % (95% CI: 38.6%-50.4%) in the non-vaccinated population while it was significantly ( p <0.001) higher in the population receiving the first dose (61.66 %, 95% CI: 54.8%-68.0%) and both (first and second) doses of vaccine (100%, 95% CI: 98.4%-100%). The mean titer of the antibody was estimated as 255.46 DU/ml and 159.08 DU/ml in the population with both doses and one dose of vaccine, respectively, compared to 53.71 DU/ml of the unvaccinated population. A decreasing trend in the titer of antibodies with increasing time after vaccination was observed. Conclusions: Seroprevalence and mean antibody titer varied according to different factors in this study. The second dose of vaccine significantly increased the seroprevalence and titer, which decreased to a certain level over time. Although antibody was produced following natural infection, the mean titer was relatively low compared to antibody after vaccination. This study emphasizes the role of the vaccine in antibody production. Based on the findings, interventions like continuing extensive mass vaccination of the leftover unvaccinated population and bringing the mass population with a second dose under a third dose campaign might be planned.

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Severity assessment of single dose Oxford–AstraZeneca vaccinated individuals infected with SARS CoV-2 in the Southeast Bangladesh

Cited by 2 publications

References 20 publications

Effect of COVID 19 vaccination on the CT severity score for SARS CoV2 pneumonia- an experience from the initial wave.

Effect of COVID 19 vaccination on the CT severity score for SARS CoV2 pneumonia- an experience from the initial wave.

Sero-prevalence of anti-SARS-CoV-2 antibodies in Chattogram Metropolitan Area, Bangladesh

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