Sero-prevalence of anti-SARS-CoV-2 antibodies in Chattogram Metropolitan Area, Bangladesh

Ara, Jahan; Islam, Md. Sirazul; Kader, Md. Tarek Ul; Das, Anan; Islam, Mohammad Saiful; Das, Seemanta; Chowdhury, M A Hassan; Das, Goutam; Chowdhury, Sharmin

doi:10.1101/2022.02.09.22270717

Cited by 4 publications

(5 citation statements)

References 48 publications

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“…Available data from serological tests allow an assessment of the level of circulation of the COVID-19 virus in the population [11]- [16]. In the field of epidemiology, it is important to know in advance the performance of new tests in the field, in order to increase the certainty of the presence or absence of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…All of these conditions limit its widespread use in resource-limited countries [10]. Seroepidemiological studies conducted in several countries and particularly in African countries show that positive case statistics based entirely on screening PCR underestimate the true extent of SARS-CoV-2 virus circulation in populations [11]- [16]. On the other hand, a meta-analysis study conducted in 2020 to describe the performance of different antigenic and serological tests in the diagnosis of COVID-19, including 25 diagnostic tests out of a total of 2247 participants, showed that only one diagnostic test had better specificity and sensitivity [17].…”

Section: Introductionmentioning

confidence: 99%

“…On the other hand, a meta-analysis study conducted in 2020 to describe the performance of different antigenic and serological tests in the diagnosis of COVID-19, including 25 diagnostic tests out of a total of 2247 participants, showed that only one diagnostic test had better specificity and sensitivity [17]. The weak performance of serological tests may contribute to the paradox between the number of cases reported in Africa and the estimates of seroprevalence studies [11]- [16]. The best serological tests for the detection of COVID-19 disease should be those that have the ability to identify positive (sensitivity) and negative (specificity) subjects.…”

Section: Introductionmentioning

confidence: 99%

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Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2

Ndziessi¹,

Ngatse²,

Niama³

et al. 2022

OJEpi

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We conducted a study to evaluate the sensitivity (Se), specificity (Sp), positive predictive value (PPV), and negative predictive value (NPV) of five serologic tests. Subjects with negative or positive COVID-19 polymerase chain reaction (PRC) test results were tested with each of the serological tests. The results were compared with the reference PCR test. For the five tests evaluated, the Se ranged from 55.0% to 70.0% and the Sp ranged from 67.2% to 86.2%. PPV ranged from 53.2% to 80% and NPV from 75.0% to 86.2%. One test, the Wantai, had better specificity and sensitivity. None of the five tests had performance values of more than 90% in the entire sample. In symptomatic positive cases, the Wantai test reported excellent sensitivity. Overall, the low level of diagnostic performance of these tests does not support their use as an alternative to PCR for COVID-19 diagnostic. Test with better performance can be used for mass screening in low prevalence populations, to limit the indiscriminate use of PCR in context of resource-limited countries. Given the excellent sensitivity of Wantai in symptomatic cases, this test could be used as a referral test only in health facilities to discriminate suspected cases before PCR confirmation.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2

Ndziessi¹,

Ngatse²,

Niama³

et al. 2022

OJEpi

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“…The highest seroprevalence rates were found in those HCWs who had previous infection(s) and were also vaccinated, but it remains unknown whether this hybrid immunity could translate into protection against the new variants of concern. In order to better understand the level of immunity to actual variants of SARS-CoV-2 and to plan interventions efficiently, the vaccination coverage and seroprevalence of SARS-CoV-2 in both the risk groups and the general community must be assessed in future perspectives [33]. Although our results in HCWs cannot be directly extrapolated to other population groups in Vojvodina and Serbia, it is reasonable to assume that the seroprevalence rates in the general population in our country are relatively high; future studies are warranted to delineate this.…”

Section: Discussionmentioning

confidence: 99%

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

et al. 2022

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Healthcare workers (HCWs) are a vulnerable and critical population in the ongoing response to the SARS-CoV-2 pandemic. We aimed to estimate the seroprevalence in HCWs considering all of their previous contacts with the SARS-CoV-2 virus and/or the immunity acquired through their immunization against COVID-19 before the advent of the Omicron variants BA.4/BA.5. Serum samples were collected from 28 March to 10 June 2022. We covered 25% out of all the people who worked in some of the government healthcare centers (primary, secondary, and tertiary level) across the entire Autonomous Province of Vojvodina (Northern Serbia). Two serological tests (Anti-SARS-CoV-2 QuantiVac ELISA and LIAISON® SARS-CoV-2 TrimericS) were used to detect anti-spike IgG antibodies. The overall prevalence of the SARS-CoV-2 antibody among the 6936 HCWs was 92.96% [95% CI 92.33–93.55]. Regarding the type of serological test, there was a statistically significant (p = 0.0079) difference of the seropositivity obtained by the LIAISON® SARS-CoV-2 TrimericS (93.87%, 95% CI 92.97–94.69) and Anti-SARS-CoV-2 QuantiVac ELISA (92.23%, 95% CI 91.34–93.06) tests. Seropositivity to SARS-CoV-2 significantly (p < 0.0001) increased with the number of SARS-CoV-2 infections combined with the number of doses of the SARS-CoV-2 vaccines received. A vast majority of the HCWs in Vojvodina had detectable levels of antibodies to the spike protein of SARS-CoV-2, but despite this high seropositivity, it is unknown whether this herd immunity among HCWs is protective against the new variants of concern. Further research should evaluate the rates of reinfections and the associated severity of COVID-19 caused by the Omicron sublineages and/or new variants of SARS-CoV-2 among HCWs.

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“…The seroprevalence study [31], which was conducted in Chattogram Metropolitan Area, Bangladesh from February to September 2021 based on the health worker, in and outpatients and garments workers, estimated the overall seroprevalence as 66.99% (95% CI: 63.40%-70.40%). There is another longitudinal cohort study [32] compared the serological response in patients with differing severity of COVID-19 infection.…”

Section: Introductionmentioning

confidence: 99%

Twice evasions of Omicron variants explain the temporal patterns in six Asia and Oceania countries

Chen

Zhao

Jin

et al. 2022

Preprint

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Background: The ongoing Coronavirus 2019 (COVID-19) pandemic has emerged and caused multiple pandemic waves in the following six countries: India, Indonesia, Nepal, Malaysia, Bangladesh and Myanmar. Some of the countries had been much less studied in this devastating pandemic. This study aims to assess the impact of Omicron variant in these six countries and estimate the infection fatality rate (IFR) and the transmission rate β(t) in the unit of basic reproduction number R 0 (t) in these six South Asia, Southeast Asia and Oceania countries.Method: We propose a Susceptible-Vaccinated-Exposed-Infectious-Hospitalized-Death-Recovered model with a time-varying transmission rate to fit the multiple waves of COVID-19 pandemic in the aforementioned six countries. The level of immune evasion and the intrinsic transmissibility advantage of Omicron variant is also estimated in this model.Results: We fit our model to the reported cases well. We estimate the IFR (in the range of 0.016% to 0.136%) and the transmission rate β(t) in the unit of basic reproduction number R 0 (t) (in the range of 0 to 9) in the six countries. The multiple pandemic waves in each country are observed in our simulation results.Conclusions: The invasion of Omicron variant caused the new pandemic waves in the six countries. The higher R 0 (t) suggests the intrinsic transmissibility advantage of Omicron variant. Our model simulation forecast implies that the Omicron pandemic wave may be mitigated due to the increasing immunized population and the vaccine coverage.

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Sero-prevalence of anti-SARS-CoV-2 antibodies in Chattogram Metropolitan Area, Bangladesh

Cited by 4 publications

References 48 publications

Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2

Diagnostic Performance of Five Rapid Serological Tests for SARS-CoV-2

Seroepidemiology of SARS-CoV-2 Virus in Healthcare Workers before Circulation of the Omicron Sublineages BA.4/BA.5 in Vojvodina, Serbia

Twice evasions of Omicron variants explain the temporal patterns in six Asia and Oceania countries

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