Severe Sepsis and Septic Shock Associated with Chikungunya Virus Infection, Guadeloupe, 2014

Abstract

During a 2014 outbreak, 450 patients with confirmed chikungunya virus infection were admitted to the University Hospital of Pointe-à-Pitre, Guadeloupe. Of these, 110 were nonpregnant adults; 42 had severe disease, and of those, 25 had severe sepsis or septic shock and 12 died. Severe sepsis may be a rare complication of chikungunya virus infection.

Chikungunya Viral Infection Requiring Intensive Care – Experience in a Tertiary Care Hospital in Bangladesh

“…Cardiovascular and neurological involvement were 34% each. This result is similar with another study 22 but differ from other studies where cardiovascular (54%) followed by neurological (37%) involvement 20 or neurological involvement was more frequent. 27 Mortality was 10% in one study where cardiac complications were common 20 and another study showed mortality is 48% in patients admitted in intensive care unit.…”

“…[22][23][24] Though the guidelines say that diarrhea and vomiting are more common in children but this study revealed that a good number of adult patients had these symptoms as well which we can find in other study also. 25,26 In this study lymphopenia was more frequent that is about 91% and thrombocytopenia was less and that is 43%.…”

“…21 Most of the affected patients were elderly patients having multiple comorbities in this study which is almost similar in other study. 22 Another study differs from this, where maximum cases were in the age group of 21-35 years (63%) having no comorbidities were reported.…”

“…Sepsis, cardiac and renal involvements were common in expired patients. 20,22,23 This was a single center study involving only one Intensive Care Unit. So no comparison with other Intensive Care Units of Bangladesh is possible through this study.…”

Emerging Viral Diseases

“…Complications occur in patients of extreme ages -> 65, children, pregnancy, co-morbiditydiabetes mellitus, hypertension, ischemic heart disease and other co-infection. 15,16 In the subacute phase the predominant features is arthritis/arthralgia and fatigue. 17 In 10-15% patients the joint symptoms progress beyond 3 months among whom 50 % patients evolve into rheumatoid arthritis or seronegative spondyloarthitides or non-specific viral arthritis.…”