Chikungunya Viral Infection Requiring Intensive Care – Experience in a Tertiary Care Hospital in Bangladesh

Nazneen, Suraiya; Saha, Madhurima; Hossain, Rakib; Ahsan, Asm Areef; Fatema, Kaniz; Ahmed, Fatema; Saha, Debasish; Sultana, Rozina

doi:10.3329/birdem.v8i1.35033

Cited by 4 publications

(7 citation statements)

References 20 publications

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“…3 Chikungunya-dengue co-infections are also to be remembered and such infections have been reported from Bangladesh. 10,[12][13][14][15] Clinical presentation of our cohort was not far different from two different reports from the same 2017 Dhaka outbreak published in literature. 9,16 Features were comparable with other chikungunya cohorts in literature as well.…”

Section: Discussionmentioning

confidence: 54%

“…8 The 2017 Dhaka outbreak was a massive one, an estimated 18 million people were affected and claimed few deaths. 4,9,10 Cases of imported chikungunya from Bangladesh have also been reported in literature. 11 The clinical manifestation of chikungunya fever is like that of other arboviral infections (like dengue) including fever, arthritis/arthralgia and rashes.…”

Section: Discussionmentioning

confidence: 97%

“…Most chikungunya cases can be managed at home but severe cases require hospitalization and sometimes intensive care. 10,18 The follow-up period of our cohort was limited. Only one-tenth of patients had passed 3 months since fever onset.…”

Section: Discussionmentioning

confidence: 99%

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Socio-demographic, Clinical and Laboratory Characteristics of a Chikungunya Cohort from the 2017 Dhaka Outbreak of Bangladesh

et al. 2019

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Background: Chikungunya is a rapidly spreading viral infection of global concern. Initial presentation of chikungunya infection is often indistinguishable from other viral infections. In Bangladesh, chikungunya is an emerging infection. In this report, we describe socio-demographic, clinical and laboratory characteristics of chikungunya in a selected group of Bangladeshi patients. Methods: A multi-center descriptive study was done including adult patients with chikungunya virus infection from July 1, 2017 to October 31, 2017. Diagnosis of chikungunya virus infection was confirmed by reverse transcriptase polymerase chain reaction (RT-PCR) or immunoglobulin M (IgM) against chikungunya. Results: Total patients were 107 including 61 (57%) males. Mean age of the study participants was 35.6 (range 19-84) years. Ninety three (86.9%) patients presented with fever and 14 (13.1%) patients (with history of recent fever) presented due to joint pain. Most (93, 86.9%) patients were managed as out-patient basis; while 14 (13.1%) patients required hospitalization. Common features were fever/history of fever, joint pain, rash and lymphadenopathy. Out of 93 patients who presented with fever, 79 (85%) had concomitant arthralgia/ arthritis, 70 (75.3%) had persistent joint symptoms beyond febrile illness requiring paracetamol, 63 (67.2%) patients had joint pain beyond 3 weeks (sub-acute phase) requiring paracetamol, non-steroidal antiinflammatory drugs or corticosteroids and 11 patients had passed 3 months since symptom onset (chronic phase) and only one (9%) had joint symptoms requiring hydroxychloroquine. There was no death. Conclusion: Clinical manifestation of chikungunya virus infection was comparable with other viral infections but arthritis/arthralgia was an important differentiating point. As chikungunya is an emerging infection in Bangladesh, physicians should have a high index of suspicion and care should be taken to exclude other viral infections specially dengue. Birdem Med J 2019; 9(2): 106-110

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Section: Discussionmentioning

confidence: 54%

Section: Discussionmentioning

confidence: 97%

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Socio-demographic, Clinical and Laboratory Characteristics of a Chikungunya Cohort from the 2017 Dhaka Outbreak of Bangladesh

et al. 2019

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“…Older people whose age is greater than 40 years, female patients and the patients having different comorbidities such as diabetes, hypertension, and cardiovascular disease have a high risk of developing this disease. 7,8,17 More than 30% patients have joint pain more than one months in the outbreak of 2011. 13 This disease is diagnosed by RT-PCR test in first week onset of the disease and IgM test between 5 days to 1 month onset of the disease.…”

Section: Discussionmentioning

confidence: 99%

“…Patients were confirmed for CHIKV disease on the basis of RT-PCR (Reverse transcription polymerase chain reaction) test in IEDCR. 14,16,17 Chikungunya virus disease has appeared as one of the major public health problem in Bangladesh, because a large proportion of population were affected by this disease. It has become a significant economic and medical burden for Bangladesh.…”

Section: Introductionmentioning

confidence: 99%

A Meta-Analysis of the Prevalence of Clinical Manifestations of Chikungunya Virus Disease in Bangladesh

Noor

Hossain

Islam³

2019

Bangla J Med

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Background: Chikungunya is known as a mosquito-borne viral disease. It is transmitted to the human body by infected mosquitoes and caused different symptoms. The main aim of this study was to investigate the percentage of Chikungunya virus disease (CHIKV) patients who would had different clinical features at the acute or sub-acute stage of this disease in Bangladesh. Methodology: In this meta-analysis, PubMed Central and BanglaJOL had been searched. Total 8 eligible studies had been selected for quantitative analysis. The pooled prevalence (PP) was used as effect measure to find the number of patients who would had different symptoms at acute or subacute stage of CHIKV disease. The pooled prevalence and 95% confidence interval (CI) had been calculated using random effects model. To measure the presence of heterogeneity Cochran chi-square test was used and I2 was used to quantify the heterogeneity. Result: This meta-analysis indicated significant association between CHIKV disease patients and fever was [PP: 0.99; p-value = 0.00], joint pain [PP: 0.95, p-value = 0.00], rash [PP: 0.55, p-value = 0.00], joint swelling [PP: 0.38, p-value = 0.001], headache [PP: 0.48, p-value = 0.007], pruritus [PP: 0.37, p-value = 0.001], myalgia [PP: 0.62, p-value = 0.00], co-morbidity [PP: 0.56, p-value = 0.001] at the acute stage of the disease and joint pain persists > 1 month [PP: 0.50, p-value = 0.001] at the subacute stage of this disease. Conclusion: In this meta-analysis ever, joint pain were found as most frequently occurred symptoms at the acute stage of CHIKV disease. Bangladesh J Medicine July 2019; 30(2) : 71-77

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Chikungunya Fever

Chandrakanta,

Prajapati,

Sah

2024

Rising Contagious Diseases

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Chikungunya Viral Infection Requiring Intensive Care – Experience in a Tertiary Care Hospital in Bangladesh

Cited by 4 publications

References 20 publications

Socio-demographic, Clinical and Laboratory Characteristics of a Chikungunya Cohort from the 2017 Dhaka Outbreak of Bangladesh

Socio-demographic, Clinical and Laboratory Characteristics of a Chikungunya Cohort from the 2017 Dhaka Outbreak of Bangladesh

A Meta-Analysis of the Prevalence of Clinical Manifestations of Chikungunya Virus Disease in Bangladesh

Chikungunya Fever

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