Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state

Pinheiro, Melina de Barros; Martins‐Filho, Olindo Assis; Mota, Ana Paula Lucas; Alpoim, Patrícia Nessralla; Godói, Lara Carvalho; Silveira, Amanda Cardoso Oliveira; Teixeira-Carvalho, Andréa; Gomes, Karina Braga; Dusse, Luci Maria Sant’Ana

doi:10.1016/j.cyto.2013.02.027

Cited by 109 publications

(85 citation statements)

References 55 publications

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“…IL-6 and IL-8 were the most responsive cytokines to TLR activation in the SGHPL-5 cell line. This is in line with TLR responses observed in primary trophoblast [7,8] and these cytokines are implicated in several pregnancy complications [31,32]. TLR3 was the most responsive TLR in the SV40 transfected trophoblast cell lines, a finding supported by others [33,34].…”

Section: Multivariate Analysis Of Tlr Gene Expression and Cytokine Resupporting

confidence: 83%

Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

et al. 2015

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Section: Multivariate Analysis Of Tlr Gene Expression and Cytokine Resupporting

confidence: 83%

Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

et al. 2015

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“…Our research group has previously reported higher levels of pro-inflammatory cytokines (IL-6, IL-8, IFN-γ and TNF-α), and decreased levels of the anti-inflammatory cytokine IL-10 in PE [16]. Other studies have also reported that maternal circulating concentration of TNF soluble receptors sTNF-R1 (55 kDa) and sTNF-R2 (75 kDa) are significantly increased in preeclamptic and normotensive pregnant women under risk to develop this disease [12], [17]–[19].…”

Section: Introductionmentioning

confidence: 81%

Soluble Endoglin, Transforming Growth Factor-Beta 1 and Soluble Tumor Necrosis Factor Alpha Receptors in Different Clinical Manifestations of Preeclampsia

Perucci¹,

Gomes

Freitas³

et al. 2014

PLoS ONE

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BackgroundDespite intensive research, the etiopathogenesis of preeclampsia (PE) remains uncertain. Inflammatory and angiogenic factors are thought to play considerable roles in this disease. The objective of this study was to investigate the association between soluble endoglin (sEng), transforming growth factor beta-1 (TGF-β1) and tumor necrosis factor alpha soluble receptors (sTNF-Rs) and the clinical manifestations of PE.MethodsPlasma levels of sEng, TGF-β1 and sTNF-Rs were determined by ELISA in 23 non-pregnant, 21 normotensive pregnant and 43 PE women. PE women were stratified into subgroups according to the severity [mild (n = 12) and severe (n = 31)] and onset-time of the disease [early (n = 19) and late (n = 24)].ResultsPregnancy was associated with higher levels of sEng, sTNF-R1 and sTNF-R2 than the non-pregnant state. Moreover, PE women had higher levels of sEng and sTNF-R1 than normotensive pregnant women. No difference was found in TGF-β1 levels, comparing the three study groups. Late PE had higher levels of sTNF-R1 and sTNF-R2 than early PE. No significant differences were found in sEng and TGF-β1 comparing early and late PE. sEng levels were higher in severe PE than in mild PE and no difference was found for TGF-β1, sTNF-R1 and sTNF-R2 levels. There was a positive correlation among sEng, TNF-R1 and sTNF-2 levels. Logistic regression analysis revealed that primiparity and sEng levels are independently associated with the development of PE. Furthermore, sEng levels are independently associated with the disease severity.ConclusionsThese results suggest that pregnancy is a condition associated with higher levels of anti-angiogenic and pro-inflammatory factors than the non-pregnant state and that PE is associated with an imbalance of these factors in the maternal circulation.

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“…Cytokines may also be involved with abnormal inflammatory responses caused by syncytiotrophoblast molecules (STBM) shed into maternal blood in PE [13]. The alteration between pro-inflammatory/regulatory responses does not occur in PE, or may be reverted in very early stages of the disease, leading to a pro-inflammatory state [23]. …”

Section: Discussionmentioning

confidence: 99%

Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia

Maharaj

Phulukdaree²,

Nagiah³

et al. 2017

PLoS ONE

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IntroductionPreeclampsia and HIV/AIDS are inflammatory conditions that contribute significantly to adverse maternal and foetal outcomes. The immune reconstitution effects of HAART on inflammatory mediators has not been adequately studied in pregnancy and may impact on the inflammatory cytokine network in women with co-morbid preeclampsia. Our study evaluated changes in pro-inflammatory cytokines IL-2, TNF-α, IFN-γ and IL-6 in HIV infected preeclamptic women on HAART.MethodsA prospective experimental study was conducted at Prince Mshiyeni Memorial Hospital between July 2013 and September 2014. One hundred and ninety three pregnant women were recruited into 4 groups: uninfected normotensive (50; 26%), infected normotensive (45; 23%), uninfected preeclamptic (53; 28%) and infected preeclamptic women (45; 23%). Serum levels of cytokines TNF-α, IFN- γ, IL-2 and IL-6 were determined using commercially available kits and a Cytometric Bead Array (CBA). Comparative data was recorded and analysed descriptively.ResultsIn the control groups (normotensive), significantly lower values were found in IL-2 (p = 0.010), TNF-α (p = 0.045), and IL-6 (p = 0.005); and a non-significant decrease was observed in IFN-γ (p = 0.345) in HIV infected women on HAART compared to uninfected controls. In the experimental group (preeclamptic) women, significantly reduced levels were observed in IL-2 and TNF-α (p = 0.001; p = 0.000) and non-significant decreases were observed in IFN-γ and IL-6 (p = 0.023; p = 0.086) in HIV infected women on HAART compared with uninfected preeclamptic women. Non-significant differences were observed between uninfected preeclamptic and normotensive women.ConclusionIn uncomplicated/normotensive pregnancies, HIV/HAART is associated with significant decreases in IL-2, TNF-α and IL-6, and in preeclamptic women significant decreases in IL-2 and TNF-α were observed. These findings suggest that HIV/HAART impacts on pro-inflammatory cytokines in women with co-morbid preeclampsia. This provides a platform for further research on immune reconstitution effects of HAART during pregnancy, and the development of potential immune modulation therapies for the management of preeclampsia.

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Severe preeclampsia goes along with a cytokine network disturbance towards a systemic inflammatory state

Cited by 109 publications

References 55 publications

Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

Toll-like receptor profiling of seven trophoblast cell lines warrants caution for translation to primary trophoblasts

Soluble Endoglin, Transforming Growth Factor-Beta 1 and Soluble Tumor Necrosis Factor Alpha Receptors in Different Clinical Manifestations of Preeclampsia

Pro-Inflammatory Cytokine Levels in HIV Infected and Uninfected Pregnant Women with and without Preeclampsia

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