Severe Postoperative Complications are Associated with Impaired Survival in Primary but not in Recurrent Retroperitoneal Sarcoma

Nizri, Eran; Netanyahu, Yael; Gerstenhaber, Fabian; Shamai, Sivan; Sher, Osnat; Merimsky, Ofer; Lahat, Guy; Klausner, Joseph M.

doi:10.1245/s10434-020-09179-x

Cited by 7 publications

(2 citation statements)

References 26 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…There was no difference between postoperative complications and 30-day mortality between the two cohorts. Resected organ score and transfusion requirements were both associated with severe postoperative complications (Clavien-Dindo ≥ 3) in the recurrent RPS cohort [57].…”

Section: Risk Associated With Recurrent Operations For Rps Recurrent ...mentioning

confidence: 90%

Morbidity and Mortality after Surgery for Retroperitoneal Sarcoma

et al. 2022

View full text Add to dashboard Cite

Retroperitoneal sarcoma (RPS) is a rare disease with over 100 histologic types and accounts for 10–15% of all soft tissue sarcomas. Due to the rarity of RPS, sarcoma centers in Europe and North America have created the Transatlantic RPS Working Group (TARPSWG) to study this disease and establish best practices for its management. Current guidelines dictate complete resection of all macro and microscopic disease as the gold standard for patients with RPS. Complete extirpation often requires a multi-visceral resection. In addition, recent evidence suggests that en bloc compartmental resections are associated with reduced rates of local recurrence. However, this approach must be balanced by the potential for added morbidity. Strategies to mitigate postoperative complications include optimization of the patient through improved preoperative nutrition and pre-habilitation therapy, referral to a high-volume sarcoma center, and implementation of enhanced recovery protocols. This review will focus on the factors associated with perioperative complications following surgery for RPS and outline approaches to mitigate poor surgical outcomes in this patient population.

show abstract

Section: Risk Associated With Recurrent Operations For Rps Recurrent ...mentioning

confidence: 90%

Morbidity and Mortality after Surgery for Retroperitoneal Sarcoma

et al. 2022

View full text Add to dashboard Cite

show abstract

“…In a retrospective study involving 393 patients with primary or recurrent RPS, it was found that patients with additional tumors exhibited worse OS, especially when the number of tumors was greater than seven [ 28 ]. Moreover, Nizri et al noted a phenomenon whereby the number of patients with multifocal disease in recurrent RPS was much larger than that in primary RPS, which further proves that multifocal disease is a major risk factor for recurrence [ 29 ]. Compared to the report conducted by Chou et al [ 30 ], our study is the largest retrospective study of RPS cases from a single center from Asia and is one of the few studies to demonstrate that multifocal disease is an independent prognostic factor for LRFS in RPS patients.…”

Section: Discussionmentioning

confidence: 99%

Impact of time to first relapse on long-term outcome in adult retroperitoneal sarcoma patients after radical resection

et al. 2022

View full text Add to dashboard Cite

Background Local recurrence of primary retroperitoneal sarcoma (RPS) is one of the major causes of treatment failure and death. We attempted to assess the effects of time to local recurrence (TLR) on the survival after recurrence (SAR) and overall survival (OS) of RPS. Methods Included in this study were 224 patients who underwent R0 resection for primary RPS at our institution between January 2000 and December 2020, 118 of whom had local recurrence. Based on the median TLR (19.8 months), patients were divided into two groups: early local recurrence (ELR < 20 months) and late local recurrence (LLR > 20 months). The Kaplan–Meier method was employed to calculate the local recurrence-free survival (LRFS), SAR and OS. Univariate and multivariate analyses were conducted to explore the prognostic value of TLR. Results The median follow-up time was 60.5 months for the entire cohort and 58.5 months for the recurrence cohort. There were 60 (50.8%) patients in the ELR group and 58 (49.2%) in the LLR group. The ELR group exhibited a worse SAR (29.2 months vs. 73.4 months, P < 0.001), OS (41.8 months vs. 120.9 months, P < 0.001), and a lower 5-year OS rate (35.9% vs. 73.2%, P = 0.004) than the LLR group. Furthermore, multivariate analysis indicated that TLR was an independent prognostic indicator for SAR (P = 0.014) and OS (P < 0.001). Conclusions In patients with RPS, ELR after R0 resection presents adverse effects on OS and SAR than those with LLR, and TLR could serve as a promising predictor for OS and SAR.

show abstract

Retroperitoneale Weichteilsarkome: Chirurgische Therapie

Willis

Schneider

2021

Chirurg

View full text Add to dashboard Cite

Severe Postoperative Complications are Associated with Impaired Survival in Primary but not in Recurrent Retroperitoneal Sarcoma

Cited by 7 publications

References 26 publications

Morbidity and Mortality after Surgery for Retroperitoneal Sarcoma

Morbidity and Mortality after Surgery for Retroperitoneal Sarcoma

Impact of time to first relapse on long-term outcome in adult retroperitoneal sarcoma patients after radical resection

Retroperitoneale Weichteilsarkome: Chirurgische Therapie

Contact Info

Product

Resources

About