Severe Pneumonia Associated with Adenovirus Type 55 Infection, France, 2014

Lafolie, J.; Mirand, Audrey; Salmona, Maud; Lautrette, Alexandre; Archimbaud, Christine; Brebion, Amélie; Regagnon, Christel; Chambon, M.; Mercier‐Delarue, Séverine; Goff, Jérôme Le; Henquell, Cécile

doi:10.3201/eid2211.160728

Cited by 27 publications

(19 citation statements)

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“…Outbreaks of HAdV-associated ARI (HAdV-ARI) in adults have been reported in communal living populations, including school, hospital, and military populations [3][4][5][6][7][8]. HAdV-55, a novel recombinant strain of HAdV-11 and HAdV-14 that causes ARI in adults [9], emerged as an epidemic strain in Asian and European countries from 2004 [6,8,[10][11][12][13][14][15][16][17][18]. In the Republic of Korea, fatal cases of HAdV-55 pneumonia among military personnel have been reported since 2012 [19], and a large military outbreak associated with HAdV-55 was observed in the winter of 2014 [20].…”

Section: Introductionmentioning

confidence: 99%

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Woo

et al. 2021

Korean J Intern Med

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0000-0002-7464-9780 *These authors contributed equally to this work. Background/Aims: Human adenovirus type 55 (HAdV-55), an emerging epidemic strain, has caused several large outbreaks in the Korean military since 2014, and HAdV-associated acute respiratory illness (HAdV-ARI) has been continuously reported thereafter. Methods: To evaluate the epidemiologic characteristics of HAdV-ARI in the Korean military, we analyzed respiratory virus polymerase chain reaction (RV-PCR) results, pneumonia surveillance results, and severe HAdV cases from all 14 Korean military hospitals from January 2013 to May 2018 and compared these data with nationwide RV surveillance data for the civilian population. Results: A total of 14,630 RV-PCRs was performed at military hospitals. HAdV (45.4%) was the most frequently detected RV, followed by human rhinovirus (12.3%) and influenza virus (6.3%). The percentage of the military positive for HAdV was significantly greater than the percentage of civilians positive for HAdV throughout the study period, with a large outbreak occurring during the winter to spring of 2014 to 2015. The outbreak continued until the end of the study, and non-seasonal detections increased over time. The reported number of pneumonia patients also increased during the outbreak. Case fatality rate was 0.075% overall but 15.6% in patients with respiratory failure. The proportion of severe patients did not change significantly during the study period. Conclusions: A large HAdV outbreak is currently ongoing in the Korean military, with a trend away from seasonality, and HAdV-55 is likely the predominant strain. Persistent efforts to control the outbreak, HAdV type-specific surveillance, and vaccine development are required.

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Section: Introductionmentioning

confidence: 99%

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Woo

et al. 2021

Korean J Intern Med

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“…Thus, HAdV‐B55 avoids herd immunity to HAdV‐B14, while retaining its respiratory pathogenicity . Recently isolated and genome‐characterized in China, HAdV‐B55 causes severe acute respiratory disease in immunocompetent adults worldwide , and of sufficient severity to warrant efforts to include it in a vaccine against other fatal respiratory adenoviruses, HAdV‐B3 and B7 . In contrast to marked hypervariability within HVRs of the HAdV‐D penton base gene and the entire fiber gene (see below), nucleotide diversity in the HAdV‐D hexon gene HVRs is comparatively less in HAdV‐Ds as compared to the other HAdV species .…”

Section: Human Adenovirus Species‐ and Type‐specific Features And Genmentioning

confidence: 99%

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

et al. 2019

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Human adenovirus commonly causes infections of respiratory, gastrointestinal, genitourinary, and ocular surface mucosae. Although most adenovirus eye infections are mild and self-limited, specific viruses within human adenovirus species D are associated with epidemic keratoconjunctivitis (EKC), a severe and highly contagious ocular surface infection, which can lead to chronic and/or recurrent, visually disabling keratitis. In this review, we discuss the links between adenovirus ontogeny, genomics, immune responses, and corneal pathogenesis, for those viruses that cause EKC.

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“…Another limitation is that no AdV typing was performed at the time of sampling, and samples were not available for retrospective analyses. Other studies have shown that AdV-55 is common in severe infections in healthy patients [4,6,10,12]. A prospective study would be needed to estimate the true incidence of AdV pneumonia in healthy and immunocompromised adults, and to establish if specific serotypes are over-represented in immunocompetent individuals.…”

mentioning

confidence: 99%

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

Cederwall

Påhlman

2019

Epidemiol. Infect.

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Adenovirus (AdV) can cause severe respiratory infections in children and immunocompromised patients, but less is known about severe AdV pneumonia in immunocompetent adults. In this retrospective study, we compared respiratory tract infections and pneumonia caused by AdV in immunocompromised and immunocompetent adult patients regarding clinical presentation and severity of infection. The results show that AdV can cause severe infections in both immunocompetent and immunocompromised patients, and the clinical presentation and need for hospitalisation, mechanical ventilation and antiviral treatment were equal in both groups. No underlying risk factors for severe AdV infection in healthy individuals were identified.

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Severe Pneumonia Associated with Adenovirus Type 55 Infection, France, 2014

Cited by 27 publications

References 10 publications

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Ongoing outbreak of human adenovirus-associated acute respiratory illness in the Republic of Korea military, 2013 to 2018

Genomic foundations of evolution and ocular pathogenesis in human adenovirus species D

Respiratory adenovirus infections in immunocompetent and immunocompromised adult patients

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