Severe Necrotizing Tracheobronchitis From Panton-Valentine Leukocidin–positive MRSA Pneumonia Complicating Influenza A-H1N1-09

Gabrilovich, Michael; Huff, Matthew; McMillen, Susan M.; Quinter, Carol

doi:10.1097/lbr.0000000000000314

Cited by 10 publications

(11 citation statements)

References 9 publications

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“…Microscope images can aid in the correct diagnosis of patients with complex respiratory conditions of similar presentation ( 1 , 14 ). Bronchoscopic findings consisted of membranous plaques, thick respiratory secretions, ulceration, or denudation of airway mucosa ( 15 ).…”

Section: Discussionmentioning

confidence: 99%

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The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis

Chen

2020

Front. Pediatr.

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Pseudomembranous necrotizing tracheitis is a rare, but life-threatening cause of central airway obstruction. Here, we reported three cases of pediatric pseudomembranous necrotizing tracheitis. The infectious etiologies were Staphylococcus aureus secondary to influenza A virus and Aspergillus fumigatus. Endoscopy was used in diagnosis and management of all patients and two patients survived. The improvement in mortality rate of these diseases need early recognition and prompt treatment with mechanical debridement by endoscope and early initiation of broad spectrum antibiotics. Endoscopy is a promising tool to diagnose and remove the pseudomembrane, therefore relieving central airway obstruction.

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Section: Discussionmentioning

confidence: 99%

“…Pseudomembranous necrotizing tracheitis is a rare, but life-threatening cause of central airway obstruction. Common infectious etiologies included bacterial, fungal, and/or viral infection(s) (1). The risk fact was bacterial infection secondary to influenza virus and long-term use of hormones or antibiotics.…”

Section: Introductionmentioning

confidence: 99%

The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis

Chen

2020

Front. Pediatr.

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“…The limited sample size resulted in the identification of only 2 pathogen species-S. aureus and K. kingae. Although TEM-PCR has been shown to reliably detect numerous bacterial and viral species in other infectious diseases [11][12][13], the sensitivity in pediatric MSKI remains unknown. Additionally, despite the strong concordance with culture-based methods, the small sample size limits the power of the study.…”

Section: Discussionmentioning

confidence: 99%

“…During the study period, 25 source specimens were collected for culture and TEM-PCR on 24 patients (1 subject was admitted twice, 2 months apart). Fourteen (58%) participants were male, with a median age (interquartile range) of 8 (3)(4)(5)(6)(7)(8)(9)(10)(11)(12) years. Seventy-one percent of the patients were non-Hispanic white, 25% were non-Hispanic black, and 4% were multiracial.…”

Section: Patient Characteristicsmentioning

confidence: 99%

Performance of TEM-PCR vs Culture for Bacterial Identification in Pediatric Musculoskeletal Infections

Wood

Sesler

Stalons

et al. 2018

Open Forum Infectious Diseases

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Improved diagnostics are needed for children with musculoskeletal infections (MSKIs). We assessed the performance of target-enriched multiplex polymerase chain reaction (TEM-PCR) in children with MSKI. TEM-PCR was concordant with culture in pathogen identification and antibiotic susceptibility testing, while increasing the overall yield of pathogen detection. This technology has the potential to inform judicious antimicrobial use early in the disease course.

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“…While influenza viruses initiate SBIs, bacteria often dictate illness severity (68,132,254). As such, the role of vaccines against bacterial pathogens in limiting coinfections must be discussed.…”

Section: Vaccines That Target Bacterial Pathogensmentioning

confidence: 99%

The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza

Smith

Huber

2018

Viral Immunology

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Influenza virus infections remain a significant health burden worldwide, despite available vaccines. Factors that contribute to this include a lack of broad coverage by current vaccines and continual emergence of novel virus strains. Further complicating matters, when influenza viruses infect a host, severe infections can develop when bacterial pathogens invade. Secondary bacterial infections (SBIs) contribute to a significant proportion of influenza-related mortality, with Streptococcus pneumoniae, Staphylococcus aureus, Streptococcus pyogenes, and Haemophilus influenzae as major coinfecting pathogens. Vaccines against bacterial pathogens can reduce coinfection incidence and severity, but few vaccines are available and those that are, may have decreased efficacy in influenza virus-infected hosts. While some studies indicate a benefit of vaccine-induced immunity in providing protection against SBIs, a comprehensive understanding is lacking. In this review, we discuss the current knowledge of viral and bacterial vaccine availability, the generation of protective immunity from these vaccines, and the effectiveness in limiting influenza-associated bacterial infections.

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Severe Necrotizing Tracheobronchitis From Panton-Valentine Leukocidin–positive MRSA Pneumonia Complicating Influenza A-H1N1-09

Cited by 10 publications

References 9 publications

The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis

The Important Role of Endoscopy in Management of Pediatric Pseudomembranous Necrotizing Tracheitis

Performance of TEM-PCR vs Culture for Bacterial Identification in Pediatric Musculoskeletal Infections

The Unexpected Impact of Vaccines on Secondary Bacterial Infections Following Influenza

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